Frederick William Woodley, PhD :: Nationwide Children's Hospital, Columbus, Ohio

Frederick W Woodley, PhD

Frederick W Woodley, PhD

Contact Information

700 Children's Drive
JWest Building
Columbus, OH 43205 [ map ]
PH: (614) 722-6413
FX: (614) 722-3454
E-mail Me

Biography

Dr. Woodley holds a PhD in molecular and cellular biology from The Ohio University and the Edison Biotechnology Institute. He is currently a senior research scientist at Nationwide Children's Hospital (NCH) where he has a clinical appointment in the Division of Gastroenterology, Hepatology and Nutrition (GI), and a research appointment in the Center for Advanced Research in Neuromuscular Gastrointestinal Disorders (CARING). He is a clinical assistant professor of pediatrics at the Ohio State University College of Medicine. His clinical responsibility at NCH is for the analysis of combined pH/multichannel intraluminal impedance (pH/MII) tracings for all pH/MII studies conducted in the GI Division. Working closely with NCH Drs. Hayat Mousa (Medical Director, CARING), Carlo Di Lorenzo (GI Division Chief), Don Hayes (Pulmonologist and Director of the Heart and Lung Transplant Program at NCH), and Ben Kopp (Pulmonologist and Principal Investigator in the Center for Microbial Pathogenesis), Dr. Woodley’s current research endeavors include studies aimed at: 1) determining the normal values of pH/MII in infants and children, 2) using pH/MII (a minimally invasive procedure) to identify patients who are at risk of aspirating gastric contents, 3) developing noninvasive procedures for identifying patients who are actively aspirating gastric contents, 4) using exhaled breath condensate to detect early signs of oxidative stress in the lungs of patients with cystic fibrosis and those with a lung transplant, 5) assessing the impact of aging on the efficiency of acid clearance in cystic fibrosis patients, and 6) using exhaled breath condensate to identify obese children who are aspirating gastric contents. Dr. Woodley has presented his research findings on gastroesophageal reflux at both national and international meetings. He is also the Zero Hero safety coach in the GI Division at NCH. In addition to his work at Nationwide Children's Hospital, Dr. Woodley is an adjunct professor at Columbus State Community College where he teaches microbiology.

Gender:

  • Male

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • Gastroesophageal and duodenogastroesophageal reflux, multichannel intraluminal impedance/pH monitoring, esophageal acid clearance mechanisms, aspiration of gastric contents, exhaled breath condensates, proteomics

Personal Interests

  • cystic fibrosis and lung transplant kids

Education and Training

Undergraduate School

  • Saint Francis University
    Date Completed: 05/06/1984

Graduate School

  • Indiana University of Pennsylvania
    Date Completed: 12/23/1989

Graduate School

  • Ohio University
    Date Completed: 06/13/1997

Postdoctoral Training

  • Edison Biotechnology Institute
    Date Completed: 11/01/1999

Department:

  • Gastroenterology, Hepatology and Nutrition

Date of Appointment at Nationwide Children’s Hospital:

  • 01/03/2004

Professional Experience

2005–2007

  • Senior Research Associate, Gastroenterology Division, Nationwide Children's Hospital

2004–2005

  • Research Associate, Gastroenterology Division, Nationwide Children's Hospital

2000–2013

  • Adjunct Professor of Microbiology, Columbus State Community College

2000–2003

  • Research Associate, Physiology and Cell Biology, Ohio State University College of Medicine

Publications

  • Woodley FW, Machado RS, Hayes D Jr, Di Lorenzo C, Kaul A, Skaggs B, McCoy K, Patel A, Mousa H. 2014. Children with cystic fibrosis have prolonged chemical clearance of acid reflux compared to syptomatic children without cystic fibrosis.  Digestive Diseases and Sciences. Vol. 59, no. 3. (March): 623-630.
  • Woodley FW, Machado RS, Hayes D Jr, Di Lorenzo C, Kaul A, Skaggs B, McCoy K, Patel A, Mousa H. 2013. Children with Cystic Fibrosis Have Prolonged Chemical Clearance of Acid Reflux Compared to Symptomatic Children Without Cystic Fibrosis.  Digestive Diseases and Sciences. Vol. ePUB, no. November: 10.1007/s10620-013.
  • Machado,Rodrigo; Woodley,Frederick,W; Skaggs,Beth; di Lorenzo,Carlo; Splaingard,Mark; Mousa,Hayat. 2013. Gastroesophageal Reflux Causing Sleep Interruptions in Infants.  JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. Vol. 56, no. 4. (April): 431-435.
  • Mousa,Hayat,M; Woodley,Frederick,W. 2012. Gastroesophageal reflux in cystic fibrosis: current understandings of mechanisms and management.  Current gastroenterology reports. Vol. 14, no. 3. (June): 226-235.
  • Woodley,Frederick,W; Machado,Rodrigo,S; Kaul,Ajay; Campbell,William; Patel,Alpa; McCoy,Karen; Mousa,Hayat. 2012. Prolonged Acid Exposure in Children With Cystic Fibrosis is Not Due to Increased Frequency of Acid Gastroesophageal Reflux but Rather to Delayed Chemical Clearance of Acid Gastroesophageal Reflux.  GASTROENTEROLOGY. Vol. 142, no. 5. (May): S290-S290.
  • Mousa,Hayat,M; Rosen,Rachel; Woodley,Frederick,W; Orsi,Marina; Armas,Daneila; Faure,Christophe; Fortunato,John; O'Connor,Judith; Skaggs,Beth; Nurko,Samuel. 2011. Esophageal Impedance Monitoring for Gastroesophageal Reflux.  JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. Vol. 52, no. 2. (February): 129-139.
  • Woodley,Frederick,W; Hayes,John; Mousa,Hayat. 2009. Acid Gastroesophageal Reflux in Symptomatic Infants Is Primarily a Function of Classic 2-phase and pH-only Acid Reflux Event Types.  JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. Vol. 48, no. 5. (May): 550-558.
  • Woodley,Frederick,W; Mousa,Hayat. 2009. "pH-Only" Acid Reflux Events in Infants During Later Phases of the Feeding Cycle Are Less Acidic and Cleared More Efficiently Than Classic 2-Phase Acid Reflux Events.  JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. Vol. 48, no. 1. (January): 41-47.
  • Woodley FW, Mousa H. 2008. Revisiting the effect of casein and whey on gastric emptying: Do differences in protein source really matter?.  Journal of Neonatal-Perinatal Medicine. Vol. Volume 1, no. Number 2 / 2008. (May): 111-117.
  • Philipose,Sujit,M; Skaggs,Beth; Hayes,John; Woodley,Frederick,W; Mousa,Hayat,M. 2008. The use of multichannel intralluminal impedance (MII) in the assessment of post-fundoplication swallowing disorders in children.  GASTROENTEROLOGY. Vol. 134, no. 4. (April): A720-A720.
  • Fernandez,Sergio,J; Aspirot,Ann; Woodley,Frederick,W; Hayes,John; Philipose,Sujit,M; Skaggs,Beth; di Lorenzo,Carlo; Mousa,Hayat. 2008. Automatic versus manual impedance readings: Should we rely on the autoscan?.  GASTROENTEROLOGY. Vol. 134, no. 4. (April): A602-A602.
  • Woodley,Frederick,W; Hayes,John; Mousa,Hayat. 2008. Is reduced chemical clearance efficiency during later phases of the feeding cycle in symptomatic infants related to declining frequency of swallowing?.  GASTROENTEROLOGY. Vol. 134, no. 4. (April): A602-A602.
  • Woodley F, Mousa H. Revisiting the effect of casein and whey on gastric emptying: do differences in protein source really matter?  J Neonatal Perinatal Med. 2008;1:111-117.
  • Mousa,Hayat,M; Woodley,Frederick,W; Conklin,Christina; Rupert,Christopher; Cowoski,Erica. 2007. "pH only" acid gastroesophageal reflux episodes are not temporally correlated with respiratory symptoms in infants.  GASTROENTEROLOGY. Vol. 132, no. 4. (April): A286-A286.
  • Woodley,Frederick,W; Gulatti,Parul; Fernandez,Soledad; Mousa,Hayat,M. 2007. Characterization of "pH only" acid gastroesophageal reflux episodes in infants.  GASTROENTEROLOGY. Vol. 132, no. 4. (April): A282-A282.
  • Woodley,Frederick,W; Fernandez,Soledad; Mousa,Hayat. 2007. Diurnal variation in the chemical clearance of acid gastroesophageal reflux in infants.  CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. Vol. 5, no. 1. (January): 37-43.
  • Woodley,Frederick,W; Mousa,Hayat. 2006. Acid gastroesophageal reflux reports in infants: A comparison of esophageal pH monitoring and multichannel intraluminal impedance measurements.  DIGESTIVE DISEASES AND SCIENCES. Vol. 51, no. 11. (November): 1910-1916.
  • Mousa,Hayat; Woodley,Frederick,W. 2006. Non-acid gastroesophageal reflux and respiratory disorders: A literature review.  OHIO JOURNAL OF SCIENCE. Vol. 106, no. 3. (June): 112-116.
  • Woodley,Frederick,W; Kim,Namhee; Fernandez,Soledad; Metheney,Melissa; Mousa,Hayat. 2006. Effects of feeding on esophageal exposure to acid gastroesophageal reflux during esophageal emptying and during subsequent mucosal acid neutralization in infants.  GASTROENTEROLOGY. Vol. 130, no. 4. (April): A116-A116.
  • Woodley,Frederick,W; Mousa,Hayat,M. 2006. Acid gastroesophageal reflux reports in infants: A comparison of esophageal pH monitoring and multichannel intraluminal impedance measurement techniques.  GASTROENTEROLOGY. Vol. 130, no. 4. (April): A170-A170.
  • Mousa,H; Woodley,F,W; Metheney,M; Hayes,J. 2005. Testing the association between gastroesophageal reflux and apnea in infants.  JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. Vol. 41, no. 2. (August): 169-177.
  • Mousa,H; Woodley,F; Gulati,P; Fernandez,S; Metheney,M. 2005. Esophageal clearance patterns of acid and non-acid reflux differ between fasting and post-prandial periods.  GASTROENTEROLOGY. Vol. 128, no. 4. (April): A412-A413.
  • Mousa,H; Woodley,F; Metheney,T; Hayes,J. 2005. Testing the association between gastroesophageal reflux (GER) and apnea in infants.  GASTROINTESTINAL ENDOSCOPY. Vol. 61, no. 5. (April): AB138-AB138.
  • Mousa,H; Woodley,F,W; Fernandez,S; Gulati,P; Metheney,M. 2005. Defining the pattern of gastroesophageal reflux and its ph status during fasting and post-prandial periods.  GASTROENTEROLOGY. Vol. 128, no. 4. (April): A387-A387.
  • Mousa,H; Woodley,F; Metheney,M; Hayes,J. 2004. The long-term outcome of fundoplication in children with gastroesophageal reflux disease: A retrospective analysis.  PEDIATRIC RESEARCH. Vol. 56, no. 4. (October): 672-672.

Awards, Honors and Organizations

  • Nationwide Children's Hospital, Employee of the Month, March 2011.
  • Nationwide Children's Hospital Impact Award, 2011. “Improving the reporting process for test results in the GI Division.”
  • Poster of Distinction. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition, November 12–14, 2009, National Harbor, Maryland. “A novel method for evaluating chemical clearance efficiency in the distal esophagus: Calculating rate of neutralization.”
  • Poster of Distinction. Digestive Diseases Week, May 18-21, 2013, Orlando, Florida. “Normal values for chemical clearance of acid gastroesophageal reflux in infants and children.”
  • Who's Who in America, 2007.
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000