David S. Hains, MD

David S. Hains, MD, is a Pediatric Nephrologist and a Principal Investigator in the Center for Clinical and Translational Research in The Research Institute at Nationwide Children's Hospital and an Assistant Professor of Pediatrics at the Ohio State University College of Medicine. Dr. Hains' NIH-funded research program focuses on the genetics of vesicoureteral reflux and its sequelae such as urinary tract infection susceptibility. He is also the Director of the Integrated Research Pathway for the Pediatric Residency Program at Nationwide Children's Hospital.

View CV »

Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Clinical and Translational Research

Areas of Interest:

• My research interests include kidney and urinary tract development specifically in regards to developmental causes of vesicoureteral reflux, which is abnormal backflow of urine from the bladder to the kidneys. Also, I am currently examining the role of DNA copy number variations in abnormal kidney and urinary tract development as well as innate immunity of the urinary tract. My researching group has discovered abnormalities in DNA copy numbers in genes important to innate immunity in patients with recurrent urinary tract infections.

Undergraduate

• Butler University
  Date Completed: 06/30/2000

Medical School

• Indiana University School of Medicine
  Date Completed: 05/09/2004

Residency

• Nationwide Children's Hospital
  Date Completed: 06/30/2007

Fellowship

• Nationwide Children's Hospital
  Date Completed: 06/30/2010

Department:

• Pediatrics

Section:

• Nephrology

Speciality:

• Pediatric Nephrology
  
• Pediatrics, Certified
  

Date of Appointment at Children's Hospital:

• 07/01/2010

2009–present

• Principal Investigator, Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH

• Schwaderer AL, Srivastava T, Schueller L, Cronin R, Mahan JD, Hains D. 2011. Dietary modifications alone do not improve bone mineral density in children with idiopathic hypercalciuria.  Clin Nephrol. (November)
• Becknell B, Hains DS, Schwaderer AL, Vanderbrink BA, Spencer JD, Reagan PB, McHugh KM. 2011. Impact of urinary tract infection on inpatient healthcare for congenital obstructive uropathy.  J Pediatr Urol. (November)
• Maguire MA, Franz T, Hains DS. 2011. A Clinically Significant Interaction between Tacrolimus and Multiple Proton Pump Inhibitors in a Kidney Transplant Recipient.  Pediatr Transplant. (August)
• Hains DS, Reagan PB, Smoyer WE. 2011. Do Declining Private Insurance Coverage Rates Influence Pediatric Hospital Charging Practices?.  Clinical Pediatrics. (May) (Formally Accepted)
• Becknell B, Pais P, Onimoe G, Rangarajan H, Schwaderer AL, McHugh KM, Ranalli MA, Hains DS. 2011. Hepatoblastoma and Prune belly syndrome: A Potential Assocation. Accepted in Pediatric Nephrology.  Pediatric Nephrology. (May) (Formally Accepted)
• Spencer JD, Schwaderer A, McHugh K, Vanderbrink B, Becknell B, Hains DS. 2011. The demographics and costs of inpatient vesicoureteral reflux management in the USA.  Pediatric Nephrology. (May)
• Spencer JD, Schwaderer A, DiRosario J, McHugh K, McGillivary G, Justice S, Carpenter A, Baker P, Harder J, and Hains DS. 2011. Ribonuclease 7: a potent antimicrobial peptide within the human urinary tract.  Kidney International. (April) (Formally Accepted)
• Becknell B; Zender GA; Houston R; Baker PB; McBride KL; Luo W; Hains DS; Borza DB; Schwaderer AL. 2011. Novel X-linked glomerulopathy is associated with a COL4A5 missense mutation in a non-collagenous interruption.  Kidney International. Vol. 79, no. 1. (January 1): 120. (Formally Accepted)
• Ayoob R, Hains DS, Smoyer WE. 2011. Trends in Hospitalization Characteristics for Pediatric Nephrotic Syndrome in the USA.  Clinical Nephrology. (Formally Accepted)
• Spencer JD, Bates CM, Mahan JD, Niland ML, Staker SR, Hains DS, Schwaderer AL. 2010. The accuracy and health risks of a voiding cystourethrogram after a febrile urinary tract infection.  J Pediatr Urol. (December)
• Spencer JD; Schwaderer A; McHugh K; Hains DS. 2010. Pediatric urinary tract infections: an analysis of hospitalizations, charges, and costs in the USA.  Pediatric Nephrology. Vol. 25, no. 12. (December 1): 2469. (Formally Accepted)
• Ingraham SE, Saha M, Carpenter AR, Robinson M, Ismail I, Singh S, Hains D, Robinson ML, Hirselj DA, Koff SA, Bates CM, McHugh KM. 2010. Pathogenesis of Renal Injury in the Megabladder Mouse: A Genetic Model of Congenital Obstructive Nephropathy.  Pediatr Res. (August)
• Hains DS; Sims-Lucas S; Carpenter A; Saha M; Murawski I; Kish K; Gupta I; McHugh K; Bates CM. 2010. High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchyma.  The Journal Of Urology. Vol. 183, no. 5. (May): 2077.
• Sims-Lucas S; Cullen-McEwen L; Eswarakumar VP; Hains D; Kish K; Becknell B; Zhang J; Bertram JF; Wang F; Bates CM. 2009. Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia.  American Journal Of Physiology. Renal Physiology. Vol. 297, no. 5. (November 1): F1208.
• Hains DS; Bates CM; Ingraham S; Schwaderer AL. 2009. Management and etiology of the unilateral multicystic dysplastic kidney: a review.  Pediatric Nephrology (Berlin, Germany). Vol. 24, no. 2. (February 1): 233.
• Hains D; Sims-Lucas S; Kish K; Saha M; McHugh K; Bates CM. 2008. Role of fibroblast growth factor receptor 2 in kidney mesenchyme.  Pediatric Research. Vol. 64, no. 6. (December 1): 592.
• Poladia DP; Kish K; Kutay B; Hains D; Kegg H; Zhao H; Bates CM. 2006. Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme.  Developmental Biology. Vol. 291, no. 2. (March 15): 325.
• Eugster EA; Hains D; DiMeglio LA. 2006. Initial management of infants with intersex conditions in a tertiary care center: a cautionary tale.  Journal Of Pediatric Endocrinology & Metabolism: JPEM. Vol. 19, no. 2. (February): 191.