David S. Hains, MD

David S. Hains, MD, is a Pediatric Nephrologist and Associate Program Director of the Nephrology Fellowship Program at Nationwide Children's Hospital. He is also a Principal Investigator in the Center for Clinical and Translational Research in The Research Institute at Nationwide Children's Hospital and an Assistant Professor of Pediatrics at the Ohio State University College of Medicine. Dr. Hains' NIH-funded research program focuses on the genetics of vesicoureteral reflux and its sequelae such as urinary tract infection susceptibility. He is also the Director of the Integrated Research Pathway for the Pediatric Residency Program at Nationwide Children's Hospital.

View CV »

Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Clinical and Translational Research

Areas of Interest:

• My research interests include kidney and urinary tract development specifically in regards to developmental causes of vesicoureteral reflux, which is abnormal backflow of urine from the bladder to the kidneys. Also, I am currently examining the role of DNA copy number variations in abnormal kidney and urinary tract development as well as innate immunity of the urinary tract. My researching group has discovered abnormalities in DNA copy numbers in genes important to innate immunity in patients with recurrent urinary tract infections.

Undergraduate School

• Butler University
  Date Completed: 06/30/2000

Medical School

• Indiana University School of Medicine
  Date Completed: 05/09/2004

Residency

• Nationwide Children's Hospital
  Date Completed: 06/30/2007

Residency

• Nationwide Children's Hospital
  Date Completed: 06/30/2010

Fellowship

• Nationwide Children's Hospital
  Date Completed: 06/30/2010

Department:

• Pediatrics

Section:

• Nephrology

Speciality:

• Pediatric Nephrology
  
• Pediatrics
  

Date of Appointment at Nationwide Children’s Hospital:

• 07/01/2010

2009–present

• Principal Investigator, Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH

• Becknell B, Hains DS, Schwaderer AL, Vanderbrink BA, Spencer JD, Reagan PB, McHugh KM. 2012. Impact of urinary tract infection on inpatient healthcare for congenital obstructive uropathy.  J Pediatr Urol. Vol. 8, no. 5. (October): 470-6.
• Carpenter A, Paulus A, Robinson M, Bates CM, Robinson ML, Hains DS, Kline D, McHugh KM. 2012. 3-dimensional morphometric analysis of murine bladder development and dysmorphogenesis.  DEVELOPMENTAL DYNAMICS. Vol. 241, no. 3. (March): 522-533.
• Spencer JD (Co-First Author), Hains DS (Co-First Author), Porter E, Bevins CL, DiRosario JD, Becknell B, Wang H, Schwaderer AL. 2012. Human Alpha Defensin 5 Expression in the Human Kidney and Urinary Tract.  PLOS ONE. Vol. 7, no. 2. (February): ee31712.
• Cha SD, Patel HP, Hains DS, Mahan JD. 2012. The effects of hypertension on cognitive function in children and adolescents.  International journal of pediatrics. Vol. 2012, no. 2012. (January): e891094.
• Schwaderer AL, Srivastava T, Schueller L, Cronin R, Mahan JD, Hains DS. 2011. Dietary modifications alone do not improve bone mineral density in children with idiopathic hypercalciuria.  CLINICAL NEPHROLOGY. Vol. 76, no. 5. (November): 341-347.
• Maguire MA, Franz T, Hains DS. 2011. A Clinically Significant Interaction between Tacrolimus and Multiple Proton Pump Inhibitors in a Kidney Transplant Recipient.  Pediatr Transplant. Vol. e-pub ahead of print, no. August: eTBD.
• Spencer JD, Schwaderer AL, Dirosario JD, McHugh KM, McGillivary G, Justice SS, Carpenter AR, Baker PB, Harder J, Hains DS. 2011. Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract.  Kidney international. Vol. 80, no. 2. (July): 174-180.
• Spencer JD, Schwaderer AL, McHugh KM, Vanderbrink B, Becknell B, Hains DS. 2011. The demographics and costs of inpatient vesicoureteral reflux management in the USA.  Pediatric Nephrology. Vol. 26, no. 11. (May): 1995-2001.
• Hains DS, Reagan PB, Smoyer WE. 2011. Do Declining Private Insurance Coverage Rates Influence Pediatric Hospital Charging Practices?.  Clinical Pediatrics. Vol. 50, no. 5. (May): 417-423.
• Becknell B, Pais P, Onimoe G, Rangarajan H, Schwaderer AL, McHugh KM, Ranalli MA, Hains, DS. 2011. Hepatoblastoma and Prune belly syndrome: A Potential Assocation. Accepted in Pediatric Nephrology.  Pediatric Nephrology. Vol. 26, no. 8. (May): 1269-1273.
• Spencer JD, Schwaderer AL, DiRosario JD, McHugh KM, McGillivary G, Justice SS, Carpenter A, Baker PB, Harder J, Hains DS. 2011. Ribonuclease 7: a potent antimicrobial peptide within the human urinary tract.  Kidney International. Vol. 80, no. 2. (April): 175-181.
• Ayoob R, Hains DS, Smoyer WE. 2011. Trends in Hospitalization Characteristics for Pediatric Nephrotic Syndrome in the USA.  Clinical Nephrology. Vol. 78, no. 2. (January): 106-111.
• Spencer JD, Schwaderer A, McHugh K, Hains DS. 2010. Pediatric urinary tract infections: an analysis of hospitalizations, charges, and costs in the USA.  Pediatric Nephrology. Vol. 25, no. 12. (December): e2469.
• Spencer JD, Bates CM, Mahan JD, Niland ML, Staker SR, Hains DS, Schwaderer AL. 2010. The accuracy and health risks of a voiding cystourethrogram after a febrile urinary tract infection.  J Pediatr Urol. Vol. 8, no. 1. (December): 72-76.
• Becknell B, Zender GA, Houston R, Baker PB, McBride KL, Luo W, Hains DS, Borza DB, Schwaderer AL. 2010. Novel X-linked glomerulopathy is associated with a COL4A5 missense mutation in a non-collagenous interruption.  Kidney International. Vol. 79, no. 1. (September): 120-127.
• Ingraham SE, Saha M, Carpenter AR, Robinson M, Ismail I, Singh S, Hains D, Robinson ML, Hirselj DA, Koff SA, Bates CM, McHugh KM. 2010. Pathogenesis of Renal Injury in the Megabladder Mouse: A Genetic Model of Congenital Obstructive Nephropathy.  Pediatr Res. Vol. 68, no. 6. (August): 500-507.
• Hains DS, Sims-Lucas S, Carpenter A, Saha M, Murawski I,, Kish K, Gupta I, McHugh K, Bates CM. 2010. High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchyma.  The Journal Of Urology. Vol. 183, no. 5. (May): 2077-2084.
• Sims-Lucas S, Cullen-McEwen L, Eswarakumar VP, Hains DS, Kish K, Becknell B, Zhang J, Bertram JF, Wang F, Bates CM. 2009. Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia.  American Journal Of Physiology. Renal Physiology. Vol. 297, no. 5. (November): F1208-F1219.
• Hains DS, Bates CM, Ingraham S, Schwaderer AL. 2009. Management and etiology of the unilateral multicystic dysplastic kidney: a review.  Pediatric Nephrology (Berlin, Germany). Vol. 24, no. 2. (February): 233-241.
• Hains DS, Sims-Lucas S, Kish K, Saha M, McHugh K, Bates CM. 2008. Role of fibroblast growth factor receptor 2 in kidney mesenchyme.  Pediatric Research. Vol. 64, no. 6. (December): 592-598.
• Hains DS and Patel HP. 2008. Use of Urinalysis and Urine Culture in Screening. In AAP Textbook of Pediatric Care. Edited by McInerny, T, Adam, H, Campbell, D, Kamat, D, Kelleher, K. Philadelphia: American Academy of Pediatrics.
• Poladia DP, Kish K, Kutay B, Hains DS, Kegg H, Zhao H, Bates CM. 2006. Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme.  Developmental Biology. Vol. 291, no. 2. (March): 325-339.
• Eugster EA, Hains DS, DiMeglio LA. 2006. Initial management of infants with intersex conditions in a tertiary care center: a cautionary tale.  Journal Of Pediatric Endocrinology & Metabolism: JPEM. Vol. 19, no. 2. (February): 191-192.
• Spencer JD, Schwaderer AL, Wang H, Bartz JD, Kline J, Eichler T, DeSouza K, Baker P and Hains DS (senior). Ribonuclease 7 is an Up-regulated Antimicrobial Peptide that Contributes to Microbial Defense of the Human Urinary Tract.  Kidney International.