David R. Repaske, MD, PhD

David R. Repaske, PhD, MD is chief of the Section of Endocrinology at Nationwide Children’s Hospital and Director of the Division of Endocrinology and Metabolism in the Department of Pediatrics at The Ohio State University based at Nationwide Children’s Hospital. Dr. Repaske is board certified in Pediatric Endocrinology. He received his PhD from the University of Wisconsin-Madison in Biochemistry and his medical degree from Vanderbilt University School of Medicine. He did his residency at the University of North Carolina at Chapel Hill. He has completed fellowships in Human Genetics at Vanderbilt and Pediatric Endocrinology at Chapel Hill. He is an advisor on a National Committee of the American Diabetes Association.

His clinical research interests include the molecular basis of inherited diabetes insipidus, optimal therapy for congenital adrenal hyperplasia, and innovations in care for diabetes and other chronic conditions.

Gender:

• Male

Languages Spoken:

• English

Medical School

• Vanderbilt University School of Medicine
  Date Completed: 05/10/1985

Fellowship

• Vanderbilt University School of Medicine
  Date Completed: 05/31/1986

Residency

• University of North Carolina at Chapel Hill Hospi
  Date Completed: 06/30/1988

Residency

• University of North Carolina at Chapel Hill Hospi
  Date Completed: 12/31/1988

Fellowship

• University of North Carolina at Chapel Hill Hospi
  Date Completed: 12/31/1991

Department:

• Pediatrics

Section:

• Endocrinology/Metabolism/Diabetes

Speciality:

• Pediatric Endocrinology
  

Date of Appointment at Nationwide Children’s Hospital:

• 04/24/2009

• Beck,Roy,W; Tamborlane,William,V; Bergenstal,Richard,M; Miller,Kellee,M; DuBose,Stephanie,N; Hall,Callyn,A. 2012. The T1D Exchange Clinic Registry.  JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. Vol. 97, no. 12. (December): 4383-4389.
• Meyer,Stacy,L; Splaingard,Mark; Repaske,David,R; Zipf,William; Atkins,Joan; Jatana,Kris. 2012. Outcomes of Adenotonsillectomy in Patients With Prader-Willi Syndrome.  ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY. Vol. 138, no. 11. (November): 1047-1051.
• Chima,Ranjit,S; Schoettker,Pamela,J; Varadarajan,Kartik,R; Kloppenborg,Elizabeth; Hutson,Tamara,K; Brilli,Richard,J; Repaske,David,R; Seid,Michael. 2012. Reduction in hypoglycemic events in critically ill patients on continuous insulin following implementation of a treatment guideline.  Quality management in health care. Vol. 21, no. 1. (January): 20-28.
• Ingerski LM, Laffel L, Dortar D, Repaske DR, Hood KK. 2010. Correlates of Glycemic Control and Quality of Life Outcomes in Adolescents with Type 1 Diabetes.  Pediatric Diabetes. Vol. 11, no. 8. (December): 563-571.
• Cortina S, Repaske DR, Hood KK. 2010. Sociodemographic and psychosocial factors associated with continuous subcutaneous insulin infusion in youth with type 1 diabetes.  Pediatric Diabetes. Vol. 11, no. August: 337-344.
• McGrady ME; Laffel L; Drotar D; Repaske D; Hood KK. 2009. Depressive symptoms and glycemic control in adolescents with type 1 diabetes: mediational role of blood glucose monitoring.  Diabetes Care. Vol. 32, no. 5. (May): e804.
• Repaske, D.R. 2009. Disorders of Water Balance. In Brook's Clinical Pediatric Endocrinology. 6th ed. Edited by Brook, C., Clayton, P., Brown, R. Chichester, West Sussex: Wiley-Blackwell.
• Repaske, D.R. 2008. Congenital Adrenal Hyperplasia. In The 5-Minute Obstetrics and Gynecology Clinical Consult. Edited by Hillard, P.J.. Philadelphia, PA: Wolters Kluwer/Lippincott Williams & Wilkins.
• Repaske, DR and Handwerger, S. 2008. Making the Trnasition from Pediatric to Adult Endocrinology.  Nature Clinical Practice Endocrinology and Metabolism. Vol. 4, no. January: 492-493.
• Siuciak JA; McCarthy SA; Chapin DS; Reed TM; Vorhees CV; Repaske DR. 2007. Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-1B (PDE1B) enzyme.  Neuropharmacology. Vol. 53, no. 1. (July): e113.
• Van Staveren WC; Steinbusch HW; Markerink-Van Ittersum M; Repaske DR; Goy MF; Kotera J; Omori K; Beavo JA; De Vente J. 2003. mRNA expression patterns of the cGMP-hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain.  The Journal Of Comparative Neurology. Vol. 467, no. 4. (December): e566.
• Santiprabhob J; Browning J; Repaske D. 2002. A missense mutation encoding Cys73Phe in neurophysin II is associated with autosomal dominant neurohypophyseal diabetes insipidus.  Molecular Genetics And Metabolism. Vol. 77, no. 1-2. (September): e112.
• Reed TM; Repaske DR; Snyder GL; Greengard P; Vorhees CV. 2002. Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learning.  The Journal Of Neuroscience: The Official Journal Of The Society For Neuroscience. Vol. 22, no. 12. (June): e5188.
• Zhang YH; Huang BL; Anyane-Yeboa K; Carvalho JA; Clemons RD; Cole T; De Figueiredo BC; Lubinsky M; Metzger DL; Quadrelli R; Repaske DR; Reyno S; Seaver LH; Vaglio A; Van Vliet G; McCabe LL; McCabe ER; Phelan JK. 2001. Nine novel mutations in NR0B1 (DAX1) causing adrenal hypoplasia congenita.  Human Mutation. Vol. 18, no. 6. (December): e547.
• King JL; Naber JM; Hopkin RJ; Repaske DR; Bailey L; Leslie ND. 2001. Antenatal corticosteroids and newborn screening for congenital adrenal hyperplasia.  Archives Of Pediatrics & Adolescent Medicine. Vol. 155, no. 9. (September): e1038.
• DiMeglio LA; Gagliardi PC; Browning JE; Quigley CA; Repaske DR. 2001. A missense mutation encoding cys(67) --> gly in neurophysin ii is associated with early onset autosomal dominant neurohypophyseal diabetes insipidus.  Molecular Genetics And Metabolism. Vol. 72, no. 1. (January): e39.
• Repaske, D.R. 1999. Molecular Basis of Inherited forms of Diabetes Insipidus. In Molecular and Cellular Basis of Pediatric Endocrinology. Edited by Handwerger, S.. Totowa, NJ: Humana Press.
• Reed TM; Browning JE; Blough RI; Vorhees CV; Repaske DR. 1998. Genomic structure and chromosome location of the murine PDE1B phosphodiesterase gene.  Mammalian Genome: Official Journal Of The International Mammalian Genome Society. Vol. 9, no. 7. (July): e571.
• Gagliardi PC; Bernasconi S; Repaske DR. 1997. Autosomal dominant neurohypophyseal diabetes insipidus associated with a missense mutation encoding Gly23-->Val in neurophysin II.  The Journal Of Clinical Endocrinology And Metabolism. Vol. 82, no. 11. (November): e3643.
• Repaske DR; Medlej R; Gültekin EK; Krishnamani MR; Halaby G; Findling JW; Phillips JA 3rd. 1997. Heterogeneity in clinical manifestation of autosomal dominant neurohypophyseal diabetes insipidus caused by a mutation encoding Ala-1-->Val in the signal peptide of the arginine vasopressin/neurophysin II/copeptin precursor.  The Journal Of Clinical Endocrinology And Metabolism. Vol. 82, no. 1. (January): e51.
• Repaske DR; Summar ML; Krishnamani MR; Gültekin EK; Arriazu MC; Roubicek ME; Blanco M; Isaac GB; Phillips JA 3rd. 1996. Recurrent mutations in the vasopressin-neurophysin II gene cause autosomal dominant neurohypophyseal diabetes insipidus.  The Journal Of Clinical Endocrinology And Metabolism. Vol. 81, no. 6. (June): e2328.
• Goy, MF, Li, Z, Zimmermann, EM, and Repaske, DR. 1996. In situ hybridization as a tool to identify neurons that express downstream components of the cyclic GMP cascade.  Methods in Neuroscience. Vol. 31, no. January: 80-111.
• Yang Q; Paskind M; Bolger G; Thompson WJ; Repaske DR; Cutler LS; Epstein PM. 1994. A novel cyclic GMP stimulated phosphodiesterase from rat brain.  Biochemical And Biophysical Research Communications. Vol. 205, no. 3. (December): e1850.
• Repaske DR; Browning JE. 1994. A de novo mutation in the coding sequence for neurophysin-II (Pro24-->Leu) is associated with onset and transmission of autosomal dominant neurohypophyseal diabetes insipidus.  The Journal Of Clinical Endocrinology And Metabolism. Vol. 79, no. 2. (August): e421.
• Repaske DR; Corbin JG; Conti M; Goy MF. 1993. A cyclic GMP-stimulated cyclic nucleotide phosphodiesterase gene is highly expressed in the limbic system of the rat brain.  Neuroscience. Vol. 56, no. 3. (October): e673.
• Repaske DR; Swinnen JV; Jin SL; Van Wyk JJ; Conti M. 1992. A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase.  The Journal Of Biological Chemistry. Vol. 267, no. 26. (September): e18683.
• Repaske, DR and Phillips, JA III. 1992. The Molecular Biology of Human hereditary Central Diabetes Insipidus. In Progress in Brain Research. Edited by Swaab, DR, Hofman, MA, Mirmiran, M, Ravid, R, nad van Leeuwen, FW. Amsterdam: Elsevier.
• VANLEEUWEN,F,W; Repaske,D,R. 1992. ANIMAL-MODELS FOR OSMOREGULATORY DISTURBANCES.  PROGRESS IN BRAIN RESEARCH. Vol. 93, no. January: 273-282.
• Repaske,D,R; Phillips,J,A; SWAAB,D,F; VANLEEUWEN,F,W; Martin,J,B. 1992. THE MOLECULAR-BIOLOGY OF HUMAN HEREDITARY CENTRAL DIABETES-INSIPIDUS.  PROGRESS IN BRAIN RESEARCH. Vol. 93, no. January: 295-308.
• Rance,N,E; Kopp,N; Braak,E; SWAAB,D,F; Braak,H; Repaske,D,R; Legros,J,J; Martin,J,B; SAPER,C,B. 1992. HORMONAL INFLUENCES ON MORPHOLOGY AND NEUROPEPTIDE GENE-EXPRESSION IN THE INFUNDIBULAR NUCLEUS OF POSTMENOPAUSAL WOMEN.  PROGRESS IN BRAIN RESEARCH. Vol. 93, no. January: 221-236.
• Reppert,S,M; SWAAB,D,F; Corner,M,A; Repaske,D,R; Mirmiran,M. 1992. PRENATAL DEVELOPMENT OF A HYPOTHALAMIC BIOLOGICAL CLOCK.  PROGRESS IN BRAIN RESEARCH. Vol. 93, no. January: 119-132.
• Conti, M, Jin, S-LC, Monaco, L, Repaske, DR, Swinnen, JV. 1991. Hormonal Regulation of Cyclic Nucleotide Phosphodiesterases.  Endocrine Reviews. Vol. 12, no. January: 218-234.
• Repaske DR; Phillips JA 3rd; Kirby LT; Tze WJ; D'Ercole AJ; Battey J. 1990. Molecular analysis of autosomal dominant neurohypophyseal diabetes insipidus.  The Journal Of Clinical Endocrinology And Metabolism. Vol. 70, no. 3. (March): e752.
• Repaske, DR and Phillips, JA III. 1987. Application of Molecular Genetics to Pediatric Gynecology.  Clinical Obstetrics and Gynecology. Vol. 30, no. January: 762-775.
• Butler MG; Repaske DR; Joseph GM; Phillips JA 3rd. 1987. High resolution chromosome and DNA analysis in multiple endocrine neoplasia type II syndrome.  Cancer Genetics And Cytogenetics. Vol. 24, no. 1. (January): e129.
• Repaske, DR and Phillips, JA III. 1986. Molecular Analysis of Familial Human Growth Hormone Disorders.  BioEssays. Vol. 4, no. January: 114-118.
• Repaske DR; Garbers DL. 1983. A hydrogen ion flux mediates stimulation of respiratory activity by speract in sea urchin spermatozoa.  The Journal Of Biological Chemistry. Vol. 258, no. 10. (May): e6025.
• Repaske DR; Adler J. 1981. Change in intracellular pH of Escherichia coli mediates the chemotactic response to certain attractants and repellents.  Journal Of Bacteriology. Vol. 145, no. 3. (March): e1196.
• Repaske, DR. 1980. Inorganic Ions in Bacterial chemotaxis: Roles of H+, Mg++, Ca++, and Membrane Potential Changes. Madison, WI: University of Wisconsin.