Daniel R. Boue, MD, PhD :: Nationwide Children’s Hospital, Columbus, Ohio

Daniel R. Boue, MD, PhD

Daniel R. Boue, MD, PhD

Anatomic Pathology
Director, Neuropathology

Clinical Pathology
Pathologist, Clinical Pathology

Neuro-Oncology
Pathologist, Neuropathology

Pathology and Laboratory Medicine
Anatomic Pathology Team

Pathology Fellowship
Faculty

Contact Information

Laboratory Medicine/Anatomic Pathology
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-5450
FX: (614) 722-2899

Biography

Daniel R. Boué, MD, PhD, is a staff pathologist in Anatomic and Clinical Pathology and Director of Neuropathology within the Department of Pathology and Laboratory Medicine at Nationwide Children’s Hospital, with an academic appointment as Associate Professor of Clinical Pathology at The Ohio State University College of Medicine. Dr. Boué is the Neuropathology Program Director for neuropathology and neurology fellows rotating from the Ohio State University Medical Center. He also is a CHTN-COG review pathologist/investigator within The Research Institute at Nationwide Children’s Hospital, Center for Biopathology, and the central review pathologist for a COG high-grade glioma study committee. His particular clinical interests are the diagnosis of pediatric brain tumors, other disorders of the pediatric nervous system, diagnosis of pediatric neuromuscular diseases, and pediatric hematopathology. His basic science and clinical research interests are in the clinico-radiologic, pathologic and molecular diagnostic and prognostic features of pediatric brain tumors. He is the principal investigator on a Nationwide Children’s Hospital Research Foundation grant to study the expression of various markers of proliferation, aggression and cell cycle regulation in pediatric brain tumors, in order to correlate expression of these markers with diagnosis, prognosis, treatment choice and outcome for these entities. Particular educational interests are in the teaching of various neuropathology topics to neurosurgery, general surgery, pathology, neurology, and pediatric residents and medical student trainees.

Gender:

  • Male

Languages Spoken:

  • English

Research Interests

Research Funding*:

  • Children’s Oncology Group/Bio-Pathology Center, National Childhood Cancer Foundation/NIH/ NCI
  • Children’s Oncology Group/Bio-pathology Center/Specimen Banking, National Childhood Cancer Foundation/COG/NIH/NCI
  • Markers of Proliferation and Aggression, and Prognosis, in Low and High Grade Pediatric Brain Tumors, J. A. Kass Memorial Endowment Fund

Education and Training

Medical School

  • University of Minnesota
    Date Completed: 06/10/1991

Internship

  • University of California San Diego Medical Center
    Date Completed: 06/30/1992

Residency

  • University of California San Diego Medical Center
    Date Completed: 06/30/1995

Fellowship

  • Nationwide Children's Hospital
    Date Completed: 01/05/1997

Fellowship

  • Nationwide Children's Hospital
    Date Completed: 06/30/1997

Department:

  • Pathology & Laboratory Medicine

Section:

  • Anatomic Pathology

Specialty:

  • Anatomic Pathology
  • Clinical Pathology
  • Pediatric Pathology

Date of Appointment at Nationwide Children’s Hospital:

  • 06/17/1997

Publications

  • 2017. Juvenile 'Perinasal' Angiofibroma.
  • Shaw A, Zibly Z, Prasad V, Ikeda D, Boue DR, Governale L. 2014. Synovial chondromatosis of the cervical spine: A case report and review of the literature.  Pediatr Dev Pathol. Vol. E pub ahead of print, no. March: eNA.
  • 2014. Synovial Chondromatosis of the Cervical Spine: A Case Report and Review of the Literature.  PEDIATRIC AND DEVELOPMENTAL PATHOLOGY. Vol. 17, no. 3. (January 1).
  • Peruzzi, PP, DR Boué, C Raffel. 2014. Cerebellar Astrocytomas. In Principles and practice of pediatric neurosurgery. Third edition. ed. Edited by Leland Albright, Ian F. Pollack, P. David Adelson.
  • 2013. Molecular and clinical characterization of the myopathic form of mitochondrial DNA depletion syndrome caused by mutations in the thymidine kinase (TK2) gene.  MOLECULAR GENETICS AND METABOLISM. Vol. 110, no. 1-2. (September 1).
  • Chanprasert S, Wang J, Weng SW, Enns GM, Boué DR, Wong BL, Mendell JR, Perry DA, Sahenk Z, Craigen WJ, Alcala FJ, Pascual JM, Melancon S, Zhang VW, Scaglia F, Wong LJ. 2013. Molecular and clinical characterization of the myopathic form of mitochondrial DNA depletion syndrome caused by mutations in the thymidine kinase (TK2) gene.  Molecular Genetics and Metabolism. Vol. 110, no. 1-2. (September 1): 153-161-153-161.
  • 2012. Ectopic cerebellum in the posterior cranial fossa.  PEDIATRIC RADIOLOGY. Vol. 42, no. 11. (November 1).
  • 2012. Synovial chondromatosis in a child's thumb: a case report and review of the literature.  Hand (New York, N.Y.). Vol. 7, no. 1. (March 1).
  • Almarzooqi S, Reed S, Fung B, Boue DR, Prasad V, Pietryga D. 2011. Infantile osteopetrosis and juvenile xanthogranuloma presenting together in a newborn: A case report and literature review.  PEDIATRIC AND DEVELOPMENTAL PATHOLOGY. Vol. 14, no. 4. (July 1): 307-312-307-312.
  • Almarzooqi S, Reed S, Fung B, Boue DR, Prasad V, Pietryga D. 2011. Infantile osteopetrosis and juvenile xanthogranuloma presenting together in a newborn: A case report and literature review.  PEDIATRIC AND DEVELOPMENTAL PATHOLOGY. Vol. 14, no. 4. (July): 307-312.
  • Gill K, Zachary B, Williams C, Raffel C, Boue D, Barson W. 2010. Recurrent meningitis in a teenager.  PEDIATRIC INFECTIOUS DISEASE JOURNAL. Vol. 29, no. 10. (October 1): 984-989-984-989.
  • Gill K, Zachary B, Williams C, Raffel C, Boue D, Barson W. 2010. Recurrent meningitis in a teenager.  PEDIATRIC INFECTIOUS DISEASE JOURNAL. Vol. 29, no. 10. (October): 984-989.
  • Weng SW, Boué DR, Wong BL, Tang LY, Mendell JR, Perry DA, Sahenk Z, Enns GM, and Wong LJ. 2009. Molecular characterization of the myopathic form of mitochondrial DNA depletion syndrome.  Mitochondrian. Vol. 9, no. 1. (January 1): 72-72.
  • Tsao C-Y, Mendell J, Sahenk Z, Rusin J, Boue D. 2008. Hypotonia, weakness, and pontocerebellar hypoplasia in siblings.  SEMINARS IN PEDIATRIC NEUROLOGY. Vol. 15, no. 4. (December): 151-153.
  • Tsao CY, Mendell J, Sahenk Z, Rusin J, Boue D. 2008. Hypotonia, weakness, and pontocerebellar hypoplasia in siblings.  Semin Pediatr Neurol. Vol. 15, no. 4. (December): 151-153.
  • Tsao C-Y, Mendell J, Sahenk Z, Rusin J, Boue D. 2008. Hypotonia, weakness, and pontocerebellar hypoplasia in siblings.  SEMINARS IN PEDIATRIC NEUROLOGY. Vol. 15, no. 4. (December 1): 151-153-151-153.
  • 2008. Idiosyncratic differentiation in medulloblastoma - a report of two exceptional cases.  NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. Vol. 34, no. 6. (December 1).
  • Tsao CY, Mendell J, Sahenk Z, Rusin J, Boue D. 2008. Hypotonia, weakness, and pontocerebellar hypoplasia in siblings.  Semin Pediatr Neurol. Vol. 15, no. 4. (December 1): 151-153-151-153.
  • Burusnukul P, de Los Reyes EC, Yinger J, Boué DR. 2008. Danon disease: an unusual presentation of autism.  Pediatr Neurol. Vol. 39, no. 1. (July 1): 52-54-52-54.
  • Burusnukul P, de los Ryes EC, Yinger J, Boue DR. 2008. Danon disease: An unusual presentation of autism.  PEDIATRIC NEUROLOGY. Vol. 39, no. 1. (July): 52-54.
  • 2008. Danon disease: An unusual presentation of autism.  PEDIATRIC NEUROLOGY. Vol. 39, no. 1. (July 1).
  • Burusnukul P, de Los Reyes EC, Yinger J, Boué DR. 2008. Danon disease: an unusual presentation of autism.  Pediatr Neurol. Vol. 39, no. 1. (July): 52-54.
  • Haidet AM, Rizo L, Handy C, Umapathi P, Eagle A, Shilling C, Boue D, Martin PT, Sahenk Z, Mendell JR, Kaspar BK. 2008. Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Vol. 105, no. 11. (March): 4318-4322.
  • Haidet AM, Rizo L, Handy C, Umapathi P, Eagle A, Shilling C, Boue D, Martin PT, Sahenk Z, Mendell JR, Kaspar BK. 2008. Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors.  Proc Natl Acad Sci U S A. Vol. 105, no. 11. (March 1): 4318-4322-4318-4322.
  • Oblinger,Janet,L; Beall,Cliff; Boue,Daniel,R; Clark,K,Reed; Sahenk,Zarife. 2008. Prevention of mtDNA depletion in quiescent skin fibroblasts from a patient with a novel R225W mutation in the TK2 gene.  NEUROLOGY. Vol. 70, no. 11. (March 1): A486-A486-A486-A486.
  • Haidet AM, Rizo L, Handy C, Umapathi P, Eagle A, Shilling C, Boue D, Martin PT, Sahenk Z, Mendell JR, Kaspar BK. 2008. Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors.  Proc Natl Acad Sci U S A. Vol. 105, no. 11. (March): 4318-4322.
  • Haidet AM, Rizo L, Handy C, Umapathi P, Eagle A, Shilling C, Boue D, Martin PT, Sahenk Z, Mendell JR, Kaspar BK. 2008. Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Vol. 105, no. 11. (March 1): 4318-4322-4318-4322.
  • Tsao, CY, J. Mendell, Z. Sahenk, J. Rusin, and D. Boué. 2008. Familial Spinal Muscular Atrophy with Type 1 Pontocerebellar Hypoplasia in Two Siblings. In Semin. Pediatr. Neurol.
  • Tsao CY, Lo WD, Rusin JA, Henwood MJ, Boue DR. 2007. Isolated neurosarcoidosis presenting as headache and spinal cord lesions mimicking central nervous system metastases.  BRAIN & DEVELOPMENT. Vol. 29, no. 8. (September 1): 514-518-514-518.
  • Tsao CY, Lo WD, Rusin JA, Henwood MJ, Boue DR. 2007. Isolated neurosarcoidosis presenting as headache and spinal cord lesions mimicking central nervous system metastases.  BRAIN & DEVELOPMENT. Vol. 29, no. 8. (September): 514-518.
  • Kesserwan C, Boue DR, Kahwash SB. 2007. Isolated juvenile xanthogranuloma in the bone marrow: Report of a case and review of the literature.  PEDIATRIC AND DEVELOPMENTAL PATHOLOGY. Vol. 10, no. 2. (March 1): 161-164-161-164.
  • 2007. Dissecting the role of endothelial SURVIVIN Delta Ex3 in angiogenesis.  BLOOD. Vol. 109, no. 4. (February 15).
  • Tsao CY, Lo WD, Rusin JA, Henwood MJ, Boué DR. 2007. Isolated neurosarcoidosis presenting as headache and multiple brain and spinal cord lesions mimicking central nervous system metastases.  Brain & Development. Vol. 29, no. 8. (January 1): 514-518-514-518.
  • Mendell JR, Boue DR, Martin PT. 2006. The congenital muscular dystrophies: Recent advances and molecular insights.  PEDIATRIC AND DEVELOPMENTAL PATHOLOGY. Vol. 9, no. 6. (November 1): 427-443-427-443.
  • 2006. The congenital muscular dystrophies: Recent advances and molecular insights.
  • Mendell JR, Boue DR, Martin PT. 2006. The congenital muscular dystrophies: Recent advances and molecular insights.  PEDIATRIC AND DEVELOPMENTAL PATHOLOGY. Vol. 9, no. 6. (November): 427-443.
  • Singh V, Boué DR. 2006. MIB-1 and Topoisomerase II alpha (Topo2a) in the grading of and prediction of outcome in pediatric ependymomas.  Brain Pathology. Vol. 16, no. 1. (September 1): S24-S24.
  • Caldas,H; Fangusaro,J,R; Boue,D,R; Holloway,M,P; Altura,R,A. 2006. Role of Survivin-Delta exon3 in angiogenesis.  FASEB JOURNAL. Vol. 20, no. 5. (March 1): A1101-A1101-A1101-A1101.
  • 2005. Survivin, Survivin-2B, and Survivin-deltaEx3 expression in medulloblastoma: biologic markers of tumour morphology and clinical outcome.  BRITISH JOURNAL OF CANCER. Vol. 92, no. 2. (January 31).
  • Singh,V; Fangusaro,J; Altura,R; Boue,D. 2004. Topoisomerase expression in central primitive neuroectodermal tumor (cPNET).  LABORATORY INVESTIGATION. Vol. 84, no. 2. (February 1): 275-275-275-275.
  • Altura RA, Olshefski RS, Jiang Y, Boue DR. 2003. Nuclear expression of Survivin in paediatric ependymomas and choroid plexus tumours correlates with morphologic tumour grade.  BRITISH JOURNAL OF CANCER. Vol. 89, no. 9. (November 1): 1743-1749-1743-1749.
  • Tsao CY, Herman G, Boue DR, Prior TW, Lo WD, Atkin JF, Rusin J. 2003. Leigh disease with mitochondrial DNA A8344G mutation: Case report and brief review.  JOURNAL OF CHILD NEUROLOGY. Vol. 18, no. 1. (January): 62-64.
  • Tsao CY, Herman G, Boue DR, Prior TW, Lo WD, Atkin JF, Rusin J. 2003. Leigh disease with mitochondrial DNA A8344G mutation: Case report and brief review.  JOURNAL OF CHILD NEUROLOGY. Vol. 18, no. 1. (January 1): 62-64-62-64.
  • 2002. Leigh syndrome associated with a homoplasmic A8344G MERRF mutation. In 52nd Annual Meeting of the American-Society-of-Human-Genetics
  • Coley BD, Rusin JA, Boue DR. 2000. Importance of hypoxic/ischemic conditions in the development of cerebral lenticulostriate vasculopathy.  PEDIATRIC RADIOLOGY. Vol. 30, no. 12. (December): 846-855.
  • Coley BD, Rusin JA, Boue DR. 2000. Importance of hypoxic/ischemic conditions in the development of cerebral lenticulostriate vasculopathy.  PEDIATRIC RADIOLOGY. Vol. 30, no. 12. (December 1): 846-855-846-855.
  • 2000. Clinicopathologic study of ectomesenchymomas from intergroup rhabdomyosarcoma study groups III and IV.  PEDIATRIC AND DEVELOPMENTAL PATHOLOGY. Vol. 3, no. 3. (May 1).
  • Boué D, Qualman S, Hammond S, Kahwash S, and Schauer G. 1998. Fatty acid oxidation disorders and sudden unexplained death in children.  Ped and Developmental Pathology. Vol. 1, no. 3. (September 1): 250-250.
  • Lo WD, Chen RJ, Boue DR, Stokes BT. 1998. Effect of neutrophil depletion in acute cerebritis.  BRAIN RESEARCH. Vol. 802, no. 1-2. (August): 175-183.
  • Lo WD, Chen RJ, Boue DR, Stokes BT. 1998. Effect of neutrophil depletion in acute cerebritis.  BRAIN RESEARCH. Vol. 802, no. 1-2. (August 1): 175-183-175-183.
  • Kim SH, Kosnik E, Madden C, Morran S, Rusin J, Gordon T, Boue D. 1998. Lytic skull metastasis from a follicular thyroid carcinoma in a child.  PEDIATRIC NEUROSURGERY. Vol. 28, no. 2. (February 1): 84-88-84-88.
  • Kim SH, Kosnik E, Madden C, Morran S, Rusin J, Gordon T, Boue D. 1998. Lytic skull metastasis from a follicular thyroid carcinoma in a child.  PEDIATRIC NEUROSURGERY. Vol. 28, no. 2. (February): 84-88.
  • Kim S, Kosnik E, Madden C, Moran D, Rusin J, Gordon T, Boué D. 1998. Lytic Skull metastases from a follicular thyroid carcinoma in a child.  Pediatric Neurosurgery. Vol. 28, no. 2. (January 1): 84-88-84-88.
  • Boué DR, Frank J, Haghighi P, Russack V. 1996. Pulmonary artery sarcoma in endarterectomy specimens: clinicopathologic study of 6 cases.  Cardiovascular Pathobiology. Vol. 1, no. 1. (January 1): 48-58-48-58.
  • 1995. Placental pathology casebook. Liveborn twin of an extramembranous pregnancy.  Journal of perinatology : official journal of the California Perinatal Association. Vol. 15, no. 6. (November 1).
  • 1995. Placental pathology casebook. Long umbilical cord with torsion and diffuse chorionic surface vein thrombosis: multiple associated congenital abnormalities including destructive encephalopathy.  Journal of perinatology : official journal of the California Perinatal Association. Vol. 15, no. 5. (September 1).
  • 1994. LINGUAL BRONCHOGENIC CYST IN A CHILD - AN UNUSUAL SITE OF PRESENTATION.  PEDIATRIC PATHOLOGY. Vol. 14, no. 2. (March 1).
  • 1988. EXPRESSION AND STRUCTURE OF CD22 IN ACUTE-LEUKEMIA.  BLOOD. Vol. 71, no. 5. (May 1).
  • Boue DR, LeBien TW. 1988. Structural characterization of the human lymphocyte-B-restricted differentiation antigen CD22 - Comparison with CD21.  JOURNAL OF IMMUNOLOGY. Vol. 140, no. 1. (January 1): 192-199-192-199.
  • Boué DR. 1988. Possible functional roles for the human B cell surface glycoproteins CD22 and CD21 (Complement Receptor Type 2/ Epstein Barr Virus receptor) during early B cell activation. In N/A.
  • Allen JI, Ferrone S, Boue D, Kay NE. 1986. The monoclonal-antibody CJA3 down regulates the susceptibility of human-tumor cell lines to natural cell-mediated cytotoxicity.  JOURNAL OF IMMUNOLOGY. Vol. 136, no. 6. (March 1): 2318-2322-2318-2322.
  • LeBien TW, Bradley JG, Boué DR, Platt LJ, Michael AF, Kersey JH. 1984. Leukocyte Typing; Human Leucocyte Differentiation Antigens Detected by Monoclonal Antibodies. In Leukocyte Typing; Human Leucocyte Differentiation Antigens Detected by Monoclonal Antibodies. Edited by A Bernard, L Boumsell, J Dausset, C Milstein, S Schlossman.
  • 1983. Abstracts.  Canadian Anaesthetists’ Society Journal. Vol. 30, no. 3. (January 1).
  • LeBien TW, Boué DR, Kersey JH. 1982. Studies of human leukemic lymphoid progenitor cell differentiation with the phorbol ester TPA. In Experimental Hematology Today. Edited by S. Baum, CD Ledney, and S Thierfelder.
  • 1982. A MONOCLONAL-ANTIBODY TO THE COMMON ALL ANTIGEN (CALLA) WHICH DOES NOT MEDIATE ANTIGENIC MODULATION INVITRO.  FEDERATION PROCEEDINGS. Vol. 41, no. 3. (January 1).
  • 1982. ANTIBODY-AFFINITY MAY INFLUENCE ANTIGENIC MODULATION OF THE COMMON ACUTE LYMPHOBLASTIC-LEUKEMIA ANTIGEN INVITRO.  JOURNAL OF IMMUNOLOGY. Vol. 129, no. 5. (January 1).
  • GW Robinson, MM Chingtagumpala, AM Adesina, S Gururangan, M Santi, A Sievert, DC Bowers, DR Boue, R Olshefski, R Cohn, B Herron, E Healy, A McCarthy, JD Dalton, A Onar, K Wright, A Gajjar, and DW Ellison. Medulloblastomas with rhabdomyoblastic and melanotic differentiation constitute a distinct disease subgroup.  N/A.
  • Pluto, CP, Rusin, JR, Ruess, L, Boué, DR, Pierson, CR. Pediatric Meningioma- Atypical and Typical.  Pediatric Radiology.
  • Caldas H, Fangusaro JR, Boué DR, Holloway, MP and Altura RA. Dissecting the Role of Endothelial Survivin-{Delta} Ex3 in Angiogenesis. Blood 109: 1479-1489, 2007.
  • Kesserwan C, Boué D, Kahwash S. Isolated Juvenile Xanthogranuloma in the Bone Marrow: Report of a Case and Review of the Literature. Pediatric and Developmental Pathology 10: 161-164, 2007.
  • Mendell JR, Boué DR, Martin P. The Congenital Muscular Dystrophies: Recent Advances and Molecular Insights. In: Perspectives in Pediatric Pathology: Pathology of the Central Nervous System and Muscles in Fetuses, Infants and Children, Volume 26, 2007.
  • Tsao CY, Lo WD, Rusin JA, Henwood MJ and Boué DR. Isolated Neurosarcoidosis presenting as Headache and Multiple Brain and Spinal Cord Lesions Mimicking Central Nervous System Metastases. Brain & Development 29(8): 514-518, 2007.

Awards, Honors and Organizations

  • Awards Committee, American Association of Neuropathologists
  • Consumers Research Council of America
  • Listed, Guide to America’s Top Pathologists
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000