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Nectotizing Enterocolitis Surgery Trial (NEST)

Purpose of study:

Previous studies suggest that the type of procedure performed for perforated necrotizing enterocolitis does not influence survival. However, long-term neurodevelopmental outcomes of these babies has not been determined. The purpose of the current study is to determine whether the initial type of surgical procedure performed for perforated necrotizing enterocolitis influences the long-term neurodevelopmental outcome of these babies.


Who can participate: 

Newborn babies in the Neonatal Intensive Care Unit with necrotizing enterocolitis and intestinal perforation.

What will happen during the study: 

Babies with necrotizing enterocolitis and intestinal perforation will be randomized to receive either exploratory laparotomy of peritoneal drainage as their initial surgical procedure. Neurodevelopmental outcome will be followed in these bables throughout the first 2 years of life.

Who to contact: 

Dr. Gail Besner, 614-722-3900
Dr. Leif Nelin, 614-722-2775
Christine Fortney, 614-722-6489 or
Christine.Fortney@nationwidechildrens.org 

Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000