Clinical Research Study Viewer

Genetics of Epilepsy Study

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What is the purpose of the study?

The purpose of this research study is to find the causes of certain epilepsies that begin during childhood or adolescence and have no known causes:

  • Juvenile Myoclonic Epilepsy (JME): In this form of epilepsy the patient has myoclonic (muscle) jerks usually of the arms and shoulders, most often in the morning after waking up.
  • Juvenile Absence Epilepsy (JAE): In this type of epilepsy the patients have brief spells of staring, each lasting a few seconds. JAE seizures usually start in adolescence but can start as early as about 8 years old. These patients may also experience grand mal seizures.
  • Epilepsy with Grand Mal Seizures upon Awakening (AGM): In this type, patients most often have seizures in the morning shortly after awakening or on awakening from a nap. These type of seizures first appear early in adolescence.
  • Random Grand Mal (RGM): This is a form of epilepsy in which grand mal seizures can occur any time of day (but usually do not occur in sleep).

Those who take part in the study will be helping to find the causes of certain seizure types and to advance science to better understand the genetic origins of epilepsy and to eventually find a cure.

Who can participate in the study?

Researchers are looking for full families with a family member who started having generalized seizures after the age of 8 years old. Participants can be family members of any age, and the current age of the person with epilepsy does not matter.

What will happen during the study?

The study consists of a short interview about medical/seizure history and a saliva sample from each family member (both the parents and any siblings) of the person with seizures. For an average family of four members, this typically takes about one hour to complete.

Who can I contact if I am interested or if I have any questions?

If you have any questions about the study, you may contact the study coordinator, Sandra Solove, at 614-355-6693 or

Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000