Clinical Research Study Viewer

Characterization of Clinical Skeletal and Cardiac Impairment in Carriers of DMD and BMD

Study Details

Principal Investigator

Samiah A. Al-Zaidy, MD, Nationwide Children’s Hospital

Study Title and Phase

Characterization of Clinical Skeletal and Cardiac Impairment in Carriers of DMD and BMD

Study Duration

2 years (3 visits over 24 months)

Inclusion Criteria

  • Age > 18
  • Cohort A requires confirmed mutation in the DMD gene with an affected son
  • Cohort B included DMD/BMD mothers with no somatic mutation in the DMD gene
  • Cohort C age-matched healthy controls with a normal CK level
  • Able to complete testing in English
  • Able to consent

Exclusion Criteria

  • Contraindication to cardiac MRI
  • Subjects on heart failure medication at the time of enrollment
  • Subjects on steroid medications
  • Presence of an inherited neurologic disease or comorbidity that may affect their ability to complete the study
  • Has a medical condition or extenuating circumstance that, in the opinion of the investigator, might compromise the subject’s ability to comply with the protocol required testing or procedures or compromise the subject’s well-being, safety, or clinical interpretability
  • Pregnancy at any time during the study

Coordinator Contact Information

Daniel Jenkins
Daniel.Jenkins@NationwideChildrens.org
614-355-3424

>> ClinicalTrials.gov link

Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000