Clinical Research Study Viewer

A Randomized Trial of Levodopa as Treatment for Residual Amblyopia

Purpose of study:

The purpose of this study is to treat amblyopia that has not responded to treatments in the past (including patching and eye drops).

Who can participate:

Children 7 to 12 years of age

What will happen during the study:

Amblyopia is usually treated with a patch or with eye drops in the good eye; forcing the child to use the weak eye. When this treatment does not cure the amblyopia, some doctors have used a drug called levodopa along with patching of the good eye to treat amblyopia. Levodopa is changed in the body to a chemical called dopamine. Dopamine is thought to have a role in how we see. It works both in the eye and in the brain. It is thought that increasing the dopamine by giving levodopa might improve vision in amblyopia. Levodopa is taken in a capsule by mouth. This study will see if taking levodopa while wearing a patch over the good eye for 2 hours/day can make amblyopia better. It will compare the levodopa group with a smaller group using placebo.

Who to contact:

Study Coordinators Amy Wagner (614.224.6222) and Rae Fellows (614.722.4080)
 

Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000