Christopher J. Phiel, Ph.D.

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Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Molecular and Human Genetics

Areas of Interest:

• My laboratory has two main research interests - Gsk–3-dependent signaling, epigenetics, and the ketogenic diet. We have several projects in the lab that touch on at least one of these areas.

  1.) Using Gsk-3-deficient mouse embryonic stem cells, we recently found a direct link between Gsk-3-mediated signaling and DNA methylation at imprinted loci. Our findings have direct implications for understanding the molecular mechanisms of imprinting. Furthermore, our data had broader implications in the areas of neuroscience and diabetes. Aberrant Gsk-3 activity has been implicated in neurological disorders such as bipolar disorder, schizophrenia, and Alzheimer's disease. In addition, Gsk-3 is a key regulator of the insulin signaling pathway, which is directly linked to type II diabetes. By finding that Gsk-3 activity regulates DNA methylation, it may now be possible to better understand how Gsk-3 activity may be involved in the pathogenesis of these disease.

  2.) We have a translational research project on understanding the molecular mechanism of the ketogenic diet, which is used effectively in the treatment of pediatric seizures. We have teamed with physicians and nurses in the Division of Neurology at Nationwide Children's Hospital in an effort to unravel the mystery of why severely limiting carbohydrates from a child's diet can have profound effects on seizure reduction. By understanding the mechanism of the ketogenic diet at a fundamental level, we hope to better predict which patients are likely to benefit from the diet, and could some day lead to the development of new treatments for pediatric epilepsy.

Undergraduate

• Ursinus College
  Date Completed: 06/30/1992

Post Doctoral

• Thomas Jefferson University
  Date Completed: 06/30/1998

Fellowship

• University of Pennysylvania, Howard Hughes Medical Institute
  Date Completed: 06/30/2003

2003–present

• Assistant Professor, Department of Pediatrics, The Ohio State University

1998–2003

• Postdoctoral Fellow, Department of Medicine, Division of Hematology/Oncology,  Howard Hughes Medical Institute, University of Pennsylvania School of Medicine

1993–1998

• Graduate Student, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University

• Zeidner, L.C., Buescher, J.L., Phiel, C.J. 2011. A Novel Interaction Between Glycogen Synthase Kinase-3? (GSK-3?) and the Scaffold Protein Receptor for Activated C-Kinase 1 (RACK1) Regulates the Circadian Clock.  Journal of International Biochemistry and Molecular Biology. (Formally Accepted)
• Qian, J., Trzepacz, C., Phiel, C.J., and Groden, J.L. 2011. A Dual-Kinase Mechanism Controls APC Phosphorylation and Dissociation From Microtubules During Mitosis.  Journal of Biological Chemistry. (Unspecified)
• Fleming, J.L., Phiel, C.J., Toland, A.E. 2011. The Role of Oxidative Stress in Aberrant DNA Methylation in Alzheimer's Disease.  Current Alzheimer's Research. no. May 24 [Epub ahead of print].
• Zeidner, L.C., Buescher, J.L., Yang, J., and Phiel, C.J. 2011. A Novel Interaction Between GSK-3? and the Scaffolding Protein RACK-1 Regulates the Circadian Clock.  World Journal of Biological Chemistry. (Unspecified)
• Fleming, J.L., Phiel, C.J., Toland, A.E. 2011. The Role for Oxidative Stress in Aberrant DNA Methylation in Alzheimer?s Disease.  Current Alzheimer Research.
• Popkie AP; Zeidner LC; Albrecht AM; D'Ippolito A; Eckardt S; Newsom DE; Groden J; Doble BW; Aronow B; McLaughlin KJ; White P; Phiel CJ. 2010. Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci.  The Journal Of Biological Chemistry. Vol. 285, no. 53. (December 31): 41337.
• He F; Popkie AP; Xiong W; Li L; Wang Y; Phiel CJ; Chen Y. 2010. Gsk3? is required in the epithelium for palatal elevation in mice.  Developmental Dynamics: An Official Publication Of The American Association Of Anatomists. Vol. 239, no. 12. (December 1): 3235.
• Yang, J. and Phiel, C.J. 2010. Functions of B56-containing PP2As in major developmental and cancer signaling pathways.  Life Sciences. Vol. 87. (December): 659-666.
• He, F., Popkie, A.P., Xiong, W., Li, L., Phiel, C.J., and Chen, Y. 2010. Gsk-3? is Required in the Epithelium for Palatal Elevation in Mice.  Developmental Dynamics. Vol. 239. (October 27): 3235-3246.
• Buescher JL; Phiel CJ. 2010. A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity.  The Journal Of Biological Chemistry. Vol. 285, no. 11. (March 12): 7957.
• Popkie, A.P., Zeidner, L.C., Albrecht, A.M., D?Ippolito, A., Eckardt, S., Newsom, D.E., Aronow, B., Groden, J., McLaughlin, K.J., White, P., and Phiel, C.J. 2010. A Novel Gsk-3-Dependent Mechanism Regulates DNA Methylation of Imprinted Genes.  Science Signaling. (First submission)
• Fleming, J.L., Phiel, C.J., and Toland, A.E. 2010. The Role for Oxidative Stress in Aberrant Epigenetic Regulation in Alzheimer?s Disease.  Current Alzheimer's Research. (First submission)
• Rorick AM, Mei W, Liette NL, Phiel C, El-Hodiri HM, Yang J. 2007. PP2A:B56epsilon is required for eye induction and eye field separation. Developmental Biology. Vol. 302, no. 2: 477-493.
• Checler F, Alves de Costa C, Ayral E, Andrau D, Dumanchin C, Farzan M, Hernandez JF, Martinez J, Lefranc-Jullien S, Marambaud P, Pasini A, Petit A, Phiel CJ, Robert P, St. George-Hyslop P, and Wilk S. 2005. JLK inhibitors: Isocoumarin compounds as putative probels to selectively target the y-secretase pathway.  Current Alzheimer Research. Vol. 2: 327-334.
• Checler, Frederic; Frederic, Checler; Alves da Costa, Cristine; Cristine, Alves da Costa; Ayral, Erwan; Erwan, Ayral; Andrau, David; David, Andrau; Dumanchin, Cecile; Cecile, Dumanchin; Farzan, Michael; Michael, Farzan; Hernandez, Jean-Francois; Jean-Francois, Hernandez; Martinez, J; Lefranc-Jullien, Solveig; Solveig, Lefranc-Jullien; Marambaud, Philippe; Philippe, Marambaud; Pasini, Andrea; et al. 2005. JLK inhibitors: isocoumarin compounds as putative probes to selectively target the gamma-secretase pathway. Current Alzheimer research. Vol. 2, no. 3: 327-34.
• Petit A; Pasini A; Alves Da Costa C; Ayral E; Hernandez JF; Dumanchin-Njock C; Phiel CJ; Marambaud P; Wilk S; Farzan M; Fulcrand P; Martinez J; Andrau D; Checler F. 2003. JLK isocoumarin inhibitors: selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo.  Journal Of Neuroscience Research. Vol. 74, no. 3. (November 1): 370.
• Zhang F; Phiel CJ; Spece L; Gurvich N; Klein PS. 2003. Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3.  The Journal Of Biological Chemistry. Vol. 278, no. 35. (August 29): 33067.
• Phiel CJ; Wilson CA; Lee VM; Klein PS. 2003. GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.  Nature. Vol. 423, no. 6938. (May 22): 435.
• Petit, A; Pasini, A; Alves Da Costa, C; Ayral, E; Hernandez, J, F; Dumanchin-Njock, C; Phiel, C, J; Marambaud, P; Wilk, S; Farzan, M; Fulcrand, P; Martinez, J; Andrau, D; Checler, F. 2003. JLK isocoumarin inhibitors: selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo. Journal of neuroscience research. Vol. 74, no. 3: 370-7.
• Gabetta, Vijayalakshmi; Trzyna, Wendy; Phiel, Christopher; McHugh, Kirk M. 2003. Vesicle-associated protein-A is differentially expressed during intestinal smooth muscle cell differentiation. Developmental dynamics : an official publication of the American Association of Anatomists. Vol. 228, no. 1: 11-20.
• Phiel CJ; Zhang F; Huang EY; Guenther MG; Lazar MA; Klein PS. 2001. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen.  The Journal Of Biological Chemistry. Vol. 276, no. 39. (September 28): 36734-36741.
• Phiel CJ; Gabbeta V; Parsons LM; Rothblat D; Harvey RP; McHugh KM. 2001. Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues.  The Journal Of Biological Chemistry. Vol. 276, no. 37. (September 14): 34637.
• Phiel, C, J; Zhang, F; Huang, E, Y; Guenther, M, G; Lazar, M, A; Klein, P S. 2001. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. The Journal of biological chemistry. Vol. 276, no. 39: 36734-41.
• Phiel CJ. 2001. Review of Molecular Targets Targets of Lithium Action, by Phiel CJ and Klein PS. Vol. 41: 789-813. (Published)
• Phiel, C, J; Klein, P S. 2001. Molecular targets of lithium action. Annual review of pharmacology and toxicology. Vol. 41: 789-813.
• Phiel CJ; Klein PS. 2001. Molecular targets of lithium action.  Annual Review Of Pharmacology And Toxicology. Vol. 41. (January 1): 789.
• Brittingham JW, Phiel CJ, Trzyna WT, Gabbeta V, and McHugh KM. 1998. Identification of Distinct Molecular Phenotypes in Cultured Gastrointestinal Smooth Muscle Cells.  Gastroenterology. Vol. 115: 605-617.
• Christopher Phiel, Speaker. April, 2001. . Department of Biology seminar series. Villanova University. Villanova, PA, USA.
  
  
• Christopher Phiel, Speaker. February, 2008. . Keystone Symposium on Wnt/Beta-catenin Signaling in Development and Disease. Keystone Symposium. Keystone, CO, USA.
  
  
• Christopher Phiel, Presenter. 2003. Title not available. Presented at Society for Neuroscience Meeting. New Orleans, LA. (November)
• Christopher Phiel, Speaker. May, 2003. . Department of Pharmacology and Institute on Aging. University of Pennsylvania. Philadelphia, PA, USA.
  
  
• Anthony Popkie, Christopher Phiel, Poster Presenter. 2007. In vivo of GSK-3alpha and GSK-3beta loss-of-function. Presented at BioOhio. Dublin, OH. (November)
• Christopher Phiel, Speaker. March, 1997. . Society for Developmental Biology - Mid-Atlantic Region. Lindenwold, NJ, USA.
  
  
• Christopher Phiel, Speaker. May, 2010. . Society for Developmental Biology - Midwest Meeting. Cincinnati Children's Hospital. Cincinnati, OH, USA.
  
  
• Buescher, Jessica L. and Christopher J. Phiel. February, 2008. The Carboxyl Termini of GSK-3 Isoforms Are Essential for Activity. . Keystone Meeting on Wnt/beta-Catenin Signaling in Development and Disease. Keystone Meeting. Poster. Keystone, CO, USA.
  
  
• Christopher Phiel, Speaker. April, 2010. . Seminar. Department of Biology, College of William and Mary. Williamsburg, VA, USA.
  
  
• Christopher Phiel, Presenter. 2003. Title not available. Presented at Child Health Seminar, Columbus Children's Research Institute. Columbus, OH. (January)
• Popkie, Anthony P., Buescher, Jessica L., Miranda, Carlos, J., Kaspar, Brian K., Doble, Bradley W., and Christopher J. Phiel. July, 2008. Analyzing the Endogeous Roles of Gsk-3 Isoforms in APP Processing in Gsk-3 Deficient Cells. . 11th International Conference on Alzheimer's Disease and Related Disorders. Talk. Chicago, IL, USA.
  
  
• Popkie, Anthony P. and Christopher J. Phiel. February, 2008. In Vivo Analysis of GSK-3alpha and GSK-3beta Loss-of-Function. . Keystone Meeting on Wnt/beta-Catenin Signaling in Development and Disease. Keystone Meeting. Poster. Keystone, CO, USA.
  
  
• Christopher Phiel, Presenter. 2001. Title not available. Presented at Department of Biology Series, Villanova University. Villanova, PA. (April)
• Popkie, Anthony P., Zeidner, Leigh C., and Christopher J. Phiel. May, 2009. Gsk-3 Regulates DNA Methylation of Imprinted Genes. . The Ohio State University Molecular Life Sciences Interdisciplinary Graduate Program Symposium. Poster. Columbus, OH, USA.
  
  
• Popkie, Anthony P., He, Fenglei, Chen, YiPing, and Christopher J. Phiel. March, 2008. In Vivo Analysis of GSK-3alpha and GSK-3beta Loss-of-Function. . The Research Institute at Nationwide Children's Hospital Annual Retreat. Poster. Columbus, OH, USA.
  
  
• Popkie, Anthony P., Zeidner, Leigh C., Albrecht, Ashley M., D'Ippolito, Anthony, Eckardt, Sigrid, Newsom, David .E., Aronow, Bruce, Groden, Joanna, McLaughlin, K. John, White, Peter, and Christopher J. Phiel. May, 2010. A Novel Gsk-3 Dependent Mechanism Regulates DNA Methylation of Imprinted Genes. . The Ohio State University Molecular Life Sciences Interdisciplinary Graduate Program Symposium. Talk. Columbus, OH, USA.
  
  
• Jessica Buescher, Christopher Phiel, Poster Presenter. 2008. The carboxyl termini of GSK-3 isoforms are essential for activity. Presented at The Research Institute at Nationwide Children's Hospital Annual Retreat. Columbus, OH. (March)
• Buescher, Jessica L. and Christopher J. Phiel. March, 2009. A Non-Catalytic Domain of GSK-3 Isoforms is Essential for Activity. . The Ohio State University Medical Center Research Day. Poster. Columbus, OH, USA.
  
  
• Phiel, Christopher J., Wilson, Christina A., Buescher, Jessica, Lee, Virginia M.-Y., and Peter S. Klein. July, 2004. A Role for GSK-3alpha in the Trafficking of APP C-Terminal Fragments. . Gordon Research Conference on Growth Factor Signaling. Poster. Oxford, UK.
  
  
• Jessica Buescher, Christopher Phiel, Poster Presenter. 2010. A non-catalytic domain of GSK-3 isoforms is essential for activity. Presented at Vanderbilt University Postdoctoral Symposium and Recruitment Day. Nashville, TN. (March)
• Jessica Buescher, Christopher Phiel, Poster Presenter. 2006. Functional analysis of GSK-3 isoforms. Presented at Children's Research Institute Annual Retreat. Newark, OH. (April)
• Christopher Phiel, Speaker. May, 2001. . University of Pennsylvania Center for Research on Reproduction and Women's Health Annual Retreat. Gregg Conference Center. Bryn Mawr, PA, USA.
  
  
• Zeidner, Leigh C., Popkie, Anthony P., and Christopher J. Phiel. April, 2005. Generation of GSK-3a Knockout Mice. . Children's Research Institute Annual Retreat. Poster. Newark, OH, USA.
  
  
• Popkie, Anthony P., Zeidner, Leigh C., Albrecht, Ashley M., D'Ippolito, Anthony, Eckardt, Sigrid, Newsom, David .E., Aronow, Bruce, Groden, Joanna, McLaughlin, K. John, White, Peter, and Christopher J. Phiel. April, 2010. A Novel Gsk-3 Dependent Mechanism Regulates DNA Methylation of Imprinted Genes. . The Research Institute at Nationwide Children's Hospital Research Week. Poster. Columbus, OH, USA.
  
  
• Jessica Buescher, Christopher Phiel, Poster Presenter. 2007. The carboxyl termini of GSK-3 isoforms are essential for activity. Presented at BioOhio. Dublin, OH. (November)
• Jessica Buescher, Christopher Phiel, Poster Presenter. 2006. Functional analysis of GSK-3 isoforms. Presented at The Ohio State University Medical Center Annual Research Day. Columbus, OH. (March)
• Buescher, Jessica L. and Christopher J. Phiel. March, 2006. Functional Analysis of GSK-3 Isoforms. . The Ohio State University Medical Center Annual Research Day. Poster. Columbus, OH, USA.
  
  
• Popkie, Anthony P. and Christopher J. Phiel. April, 2006. Generation of GSK-3alpha and GSK-3beta Conditional Knockout Mice. . Children's Research Institute Annual Retreat. Poster. Newark, OH, USA.
  
  
• Anthony Popkie, Jessica Buescher, Carlos Miranda, Brian Kaspar, Bradley Doble, Christopher Phiel, Presenter. 2008. Analyzing the endogenous roles of GSK-3 isoforms in APP processing in GSK-3 deficient cells. Presented at 11th International Conference on Alzheimer's Disease and Related Disorders. Chicago, IL. (July)
• Jessica Buescher, Christopher Phiel, Poster Presenter. 2007. The carboxyl termini of GSK-3 isoforms is required for function. Presented at Children's Research Institute Annual Retreat. Columbus, OH. (April)
• Popkie, Anthony P. and Christopher J. Phiel. May, 2007. Generation of GSK-3alpha and GSK-3beta Conditional Knockout Mice. . Annual Molecular Life Sciences-Interdisciplinary Graduate Program Symposium. Poster. Columbus, OH, USA.
  
  
• Alison Diller, Leigh Zeidner, Christopher Phiel, Poster Presenter. 2006. Novel post-translational modification of the amyloid precursor protein. Presented at The Ohio State University Medical Center Annual Research Day. Columbus, OH. (March)
• Christopher Phiel, Speaker. January, 2003. . Child Health Seminar Series. Columbus Children's Research Institute. Columbus, OH, USA.
  
  
• Christopher Phiel, Presenter. 2006. Title not available. Presented at Mini-Symposium on Alzheimer's Disease, The Ohio State University. Columbus, OH. (February)
• Christopher Phiel, Presenter. 2004. Drug Discovery in Neurodegenerative Diseases. Presented at Cold Spring Harbor Laboratory. Cold Spring Harbor, NY. (December)
• Christopher Phiel, Christina Wilson, Jessica Buescher, Virginia Lee, Peter Klein, Poster Presenter. 2004. A role for GSK-3alpha in the trafficking of APP C-terminal fragments. Presented at Gordon Research Conference on Growth Factor Signaling. Oxford, UK. (July)
• Buescher, Jessica L. and Christopher J. Phiel. July, 2008. The Carboxyl Termini of GSK-3 Isoforms Are Essential for Activity. . 10th International Conference on Alzheimer's Disease and Related Disorders. Poster. Chicago, IL, USA.
  
  
• Anthony Popkie, Christopher Phiel, Poster Presenter. 2007. Generation of GSK-3alpha and GSK-3beta conditional knockout mice. Presented at Children's Research Institute Annual Retreat. Columbus, OH. (April)
• Popkie, Anthony P., Zeidner, Leigh C., and Christopher J. Phiel. May, 2009. Gsk-3 Regulates DNA Methylation of Imprinted Genes. . The Research Institute at Nationwide Children's Hospital Research Day. Talk. Columbus, OH, USA.
  
  
• Christopher J. Phiel, Christina A. Wilson, Virginia M.-Y. Lee, Peter S. Klein, Inventor. filed February 19, 2003. (patent pending) Regulation of GSK-3a Acrivity for the Treatment or Prevention of Alzheimer's disease. patent no. 10-368,769.
• Christopher Phiel, Speaker. January, 2005. . Integrated Biomedical Science Graduate Program faculty seminar. Columbus, OH, USA.
  
  
• Anthony Popkie, Leigh Zeidner, Christopher Phiel, Poster Presenter. 2009. GSK-3 regulates DNA methylation of imprinted genes. Presented at The Ohio State University Molecular Life Sciences Interdisciplinary Graduate Program Symposium. Columbus, OH. (May)
• Christopher Phiel, Speaker. December, 2009. . OSU Comprehensive Cancer Center Monthly Molecular Biology and Cancer Genetics Meeting. The Ohio State University. Columbus, OH, USA.
  
  
• Christopher Phiel, Speaker. June, 2010. . BOSS Seminar Series. performer(s): E. Steve Roach, Debbie Terry, and Christopher Phiel. Nationwide Children's Hospital. Columbus, OH, USA.
  
  33% Authorship.
• Buescher, Jessica L. and Christopher J. Phiel. March, 2008. The Carboxyl Termini of GSK-3 Isoforms Are Essential for Activity. . The Research Institute at Nationwide Children's Hospital Annual Retreat. Poster. Columbus, OH, USA.
  
  
• Christopher Phiel, E. Steve Roach, Debbie Terry, Presenter. 2010. Pediatric Epilepsy and the Ketogenic Diet. Presented at BOSS (Bench to Outcomes Seminar Series), The Research Institute at Nationwide Children's Hospital. Columbus, OH. (May)
• Christopher Phiel, Christina Wilson, Jessica Buescher, Virginia Lee, Peter Klein, Poster Presenter. 2004. A role for GSK-3alpha in the trafficking of APP C-terminal fragments. Presented at 9th International Conference on Alzheimer's Disease and Related Disorders. Philadelphia, PA. (July)
• Phiel, Christopher J., Wilson, Christina A., Buescher, Jessica, Lee, Virginia M.-Y., and Peter S. Klein. July, 2004. A Role for GSK-3alpha in the Trafficking of APP C-Terminal Fragments. . 9th International Conference on Alzheimer's Disease and Related Disorders. Poster. Philadelphia, PA, USA.
  
  
• Popkie, Anthony P. and Christopher J. Phiel. April, 2007. Generation of GSK-3alpha and GSK-3beta Conditional Knockout Mice. . Children's Research Institute Annual Retreat. Poster. Coulmbus, OH, USA.
  
  
• Christopher Phiel, Presenter. 2010. Title not available. Presented at Department of Biology Seminar, College of William and Mary. Williamsburg, VA. (April)
• Christopher Phiel, Speaker. July, 1998. . Meeting of the American Motility Society. Philadelphia, PA, USA.
  
  
• Diller, Alison N., Zeidner, Leigh C., and Christopher J. Phiel. April, 2006. Novel Post-Translational Modification of the Amyloid Precursor Protein. . Children's Research Institute Annual Retreat. Poster. Newark, OH, USA.
  
  
• Popkie, Anthony P. and Christopher J. Phiel. November, 2007. In Vivo Analysis of GSK-3alpha and GSK-3beta Loss-of-Function. . BioOhio. Poster. Dublin, OH, USA.
  
  
• Christopher Phiel, Speaker. October, 2007. . Center for Molecular Neurobiology Seminar Series. Center for Molecular Neurobiology, The Ohio State University. Columbus, OH, USA.
  
  
• Christopher Phiel, Presenter. 2005. Title not available. Presented at Integrated Biomedical Science Graduate Program Faculty Seminar. Columbus, OH. (January)
• Jessica Buescher, Christopher Phiel, Poster Presenter. 2008. The carboxyl termini of GSK-3 isoforms are essential for activity. Presented at 10th International Conference on Alzheimer's Disease and Related Disorders. Chicago, IL. (July)
• Anthony Popkie, Leigh Zeidner, Ashley Albrecht, Anthony D'Ippolito, Sigrid Eckardt, David Newsom, Bruce Aronow, Joanna Groden, K. John McLaughlin, Peter White, Christopher Phiel, Presenter. 2010. A novel GSK-3 dependent mechanism regulates DNA methylation of imprinted genes. Presented at The Ohio State University Molecular Life Sciences Interdisciplinary Graduate Program Symposium. Columbus, OH. (May)
• Popkie, Anthony P., Zeidner, Leigh C., Albrecht, Ashley M., D'Ippolito, Anthony, Eckardt, Sigrid, Newsom, David .E., Aronow, Bruce, Groden, Joanna, McLaughlin, K. John, White, Peter, and Christopher J. Phiel. April, 2010. A Novel Gsk-3 Dependent Mechanism Regulates DNA Methylation of Imprinted Genes. . The Ohio State University Medical Center Trainee Research Day. Poster. Columbus, OH, USA.
  
  
• Christopher Phiel, Speaker. September, 2002. . Department of Pharmacology. Pennsylvania State University. Hershey, PA, USA.
  
  
• Leigh Zeidner, Anthony Popkie, Christopher Phiel, Poster Presenter. 2005. Generation of GSK-3alpha knockout mice. Presented at Children's Research Institute Annual Retreat. Newark, OH. (April)
• Leigh Zeidner, Alison Diller, Christopher Phiel, Poster Presenter. 2007. A functional analysis of the amyloid precursor protein carboxyl-terminus. Presented at Children's Research Institute Annual Retreat. Columbus, OH. (April)
• Buescher, Jessica L. and Christopher J. Phiel. November, 2007. The Carboxyl Termini of GSK-3 Isoforms Are Essential for Activity. . BioOhio. Poster. Dublin, OH, USA.
  
  
• Christopher Phiel, Presenter. 2009. Title not available. Presented at The Child Health Research Center Speaker Series, Nationwide Children's Hospital. Columbus, OH. (November)
• Anthony Popkie, Leigh Zeidner, Ashley Albrecht, Anthony D'Ippolito, Sigrid Eckardt, David Newsom, Bruce Aronow, Joanna Groden, K. John McLaughlin, Peter White, Christopher Phiel, Poster Presenter. 2010. A novel GSK-3 dependent mechanism regulates DNA methylation of imprinted genes. Presented at The Research Institute at Nationwide Children's Hospital Research Week. (April)
• Alison Diller, Leigh Zeidner, Christopher Phiel, Poster Presenter. 2006. Novel post-translational modification of the amyloid precursor protein. Presented at Children's Research Institute Annual Retreat. Newark, OH. (April)
• Christopher Phiel, Speaker. November, 2003. . Society for Neuroscience Meeting. New Orleans Convention Center. New Orleans, LA, USA.
  
  
• Christopher Phiel, Speaker. July, 2002. . 8th International Conference on Alzheimer's Disease and Related Disorders. Stockholm, Sweden.
  
  
• Zeidner, Leigh C., Diller, Alison N., and Christopher J. Phiel. April, 2007. A Functional Analysis of the Amyloid Precursor Protein Carboxyl-Terminus. . Children's Research Institute Annual Retreat. Poster. Columbus, OH, USA.
  
  
• Buescher, Jessica L. and Christopher J. Phiel. May, 2009. A Non-Catalytic Domain of GSK-3 Isoforms is Essential for Activity. . The Research Institute at Nationwide Children's Hospital Annual Retreat. Poster. Columbus, OH, USA.
  
  
• Anthony Popkie, Fenglei He, YiPang Chen, Christopher Phiel, Poster Presenter. 2008. In vivo analysis of GSK-3alpha and GSK-3beta loss-of-function. Presented at The Research Institute at Nationwide Children's Hospital Annual Retreat. Columbus, OH. (March)
• Christopher Phiel, Speaker. August, 2004. . Esai Pharmaceuticals. London, UK.
  
  
• Anthony Popkie, Jessica Buescher, Carlos Miranda, Brian Kaspar, Bradley Doble, Christopher Phiel, Poster Presenter. 2008. Analyzing the endogenous roles of GSK-3 isoforms in APP processing in GSK-3 deficient cells. Presented at The Research Institute at Nationwide Children's Hospital Annual Retreat. Columbus, OH. (March)
• Popkie, Anthony P., Buescher, Jessica L., Miranda, Carlos, J., Kaspar, Brian K., Doble, Bradley W., and Christopher J. Phiel. March, 2008. Analyzing the Endogenous Roles of Gsk-3 Isoforms in APP Processing in Gsk-3 Deficient Cells. . The Research Institute at Nationwide Children's Hospital Annual Retreat. Poster. Columbus, OH, USA.
  
  
• Christopher Phiel, Presenter. 2009. Title not available. Presented at The Ohio State University Comprehensive Cancer Center Monthly Molecular Biology and Cancer Genetics Meeting. Columbus, OH. (December)
• Christopher Phiel, Presenter. 1997. Title not available. Presented at Society for Developmental Biology, Mid-Atlantic Region. Lindenwold, NJ. (March)
• Jessica Buescher, Christopher Phiel, Poster Presenter. 2008. The carboxyl termini of GSK-3 isoforms are essential for activity. Presented at Keystone Meeting on Wnt/beta-Catenin Signaling in Development and Disease. Keystone, CO. (February)
• Anthony Popkie, Christopher Phiel, Poster Presenter. 2008. In vivo analysis of GSK-3alpha and GSK-3beta loss-of-function. Presented at Keystone Meeting on Wnt/beta-Catenin Signaling in Development and Disease. (February)
• Christopher Phiel, Speaker. December, 2004. . Drug Discovery in Neurodegenerative Diseases. Cold Spring Harbor Laboratory. Cold Spring Harbor, NY, USA.
  
  
• Christopher Phiel, Presenter. 2004. Title not available. Presented at Department of Biology Series, Ohio Wesleyan University. Delaware, OH. (October)
• Buescher, Jessica L. and Christopher J. Phiel. March, 2010. A Non-Catalytic Domain of GSK-3 Isoforms is Essential for Activity. . Vanderbilt University Postdoctoral Symposium and Recruitment Day. Poster. Nashville, TN, USA.
  
  
• Anthony Popkie Christopher Phiel, Poster Presenter. 2007. Generation of GSK-3alpha and GSK-3beta conditional knockout mice. Presented at Annual Molecular Life Sciences-Interdisciplinary Graduate Program Symposium. Columbus, OH. (May)
• Christopher Phiel, Presenter. 2002. Title not available. Presented at 8th International Conference on Alzheimer's Disease and Related Disorders. Stockholm, Sweden. (July)
• Diller, Alison N., Zeidner, Leigh C., and Christopher J. Phiel. March, 2006. Novel Post-Translational Modification of the Amyloid Precursor Protein. . The Ohio State University Medical Center Annual Research Day. Poster. Columbus, OH, USA.
  
  
• Christopher Phiel, Speaker. October, 2004. . Department of Biology seminar series. Ohio Wesleyan University. Delaware, OH, USA.
  
  
• Christopher Phiel, Presenter. 1998. Title not available. Presented at Meeting of the American Motility Society. Philadelphia, PA. (July)
• Diller, Alison N., Buescher, Jessica L., and Christopher J. Phiel. November, 2007. Molecular Analysis of the Endogenous Roles for GSK-3 Isoforms in the Development of Alzheimer's Disease Pathology. . BioOhio. Poster. Dublin, OH, USA.
  
  
• Christopher Phiel, Speaker. November, 2009. . The Child Health Research Center Speaker Series. Nationwide Children's Hospital. Columbus, OH, USA.
  
  
• Christopher Phiel, Presenter. 2010. Title not available. Presented at Society for Developmental Biology, Midwest Meeting, Cincinnati Children's Hospital. Cincinnati, OH. (May)
• Alison Diller, Jessica Buescher, Christopher Phiel, Poster Presenter. 2007. Molecular analysis of the endogenous roles for GSK-3 isoforms in the development of Alzheimer's Disease pathology. Presented at BioOhio. Dublin, OH. (November)
• Christopher Phiel, Presenter. 2002. Title not available. Presented at Department of Pharmacology, Pennsylvania State University. Hershey, PA. (September)
• Christopher J. Phiel, Speaker. February, 2006. . Mini-Symposium on Alzheimer's Disease. The Ohio State University. Columbus, OH, USA.
  
  
• Anthony Popkie, Christopher Phiel, Poster Presenter. 2006. Generation of GSK-3alpha and GSK-3beta conditional knockout mice. Presented at Children's Research Institute Annual Retreat. Newark, OH. (April)
• Buescher, Jessica L. and Christopher J. Phiel. April, 2006. Functional Analysis of GSK-3 Isoforms. . Children's Research Institute Annual Retreat. Poster. Newark, OH, USA.
  
  
• Christopher Phiel, Presenter. 2001. Title not available. Presented at University of Pennsylvania's Center for Research on Reproduction and Women's Health Annual Retreat. Bryn Mawr, PA. (May)
• Christopher Phiel, Presenter. 2004. Title not available. Presented at Esai Pharmceuticals. London, UK. (August)
• Jessica Buescher, Christopher Phiel, Poster Presenter. 2009. A non-catalytic domain of GSK-3 isoforms is essential for activity. Presented at The Research Institute at Nationwide Children's Hospital Annual Retreat. Columbus, OH. (May)
• Christopher Phiel, Presenter. 2008. Title not available. Presented at Keystone Symposium on Wnt/beta-catenin Signaling in Development and Disease. Keystone, CO. (February)
• Buescher, Jessica L. and Christopher J. Phiel. April, 2007. The Carboxyl Termini of GSK-3 Isoforms is Required for Function. . Children's Research Institute Annual Retreat. Poster. Columbus, OH, USA.
  
  
• Jessica Buescher, Christopher Phiel, Poster Presenter. 2009. A non-catalytic domain of GSK-3 isoforms is essential for activity. Presented at The Ohio State University Medical Center Research Day. Columbus, OH. (March)
• Christopher Phiel, Presenter. 2003. Title not available. Presented at Department of Pharmacology and Institute on Aging, University of Pennsylvania. Philadelphia, PA. (May)
• Anthony Popkie, Leigh Zeidner, Christopher Phiel, Presenter. 2009. GSK-3 regulates DNA methylation of imprinted genes. Presented at The Research Institute at Nationwide Children's Hospital Research Day. Columbus, OH. (May)