My lab focuses on understanding the role of Notch1 in the development and progression of abdominal aortic aneurysm (AAA). Notch1 signaling has recently gained substantial interest because of its potential participation in a diverse array of inflammatory diseases. AAA, defined as a localized dilation of the abdominal aorta, is a life-threatening disease, which has an estimated incidence of 2-4% in the adult population. AAA is characterized by activation of the inflammatory response causing extensive remodeling of the aortic wall. To understand the role of Notch1 in AAA, our laboratory has generated various knockout mice and has reported that loss of Notch1 interferes with the development of AAA at the initial stages by preventing the recruitment of inflammatory cells. Our long term goal is to determine if pharmacologic inhibition of Notch signaling is a viable therapeutic strategy to modulate AAA.
Acharya A, Hans CP, Koenig SN, Nichols HA, Galindo CL, Garner HR, Merrill WH, Hinton RB, Garg V. 2011. Inhibitory role of Notch1 in calcific aortic valve disease. PLoS One. Vol. 6(11), no. November: ee27743. PubMed ID: 22110751
Zerfaoui M; Naura AS; Errami Y; Hans CP; Rezk BM; Park J; Elsegeiny W; Kim H; Lord K; Kim JG; Boulares AH. 2009. Effects of PARP-1 deficiency on airway inflammatory cell recruitment in response to LPS or TNF: differential effects on CXCR2 ligands and Duffy Antigen Receptor for Chemokines. Journal Of Leukocyte Biology. Vol. 86, no. 6. (December): e1385.
Naura AS; Hans CP; Zerfaoui M; Errami Y; Ju J; Kim H; Matrougui K; Kim JG; Boulares AH. 2009. High-fat diet induces lung remodeling in ApoE-deficient mice: an association with an increase in circulatory and lung inflammatory factors. Laboratory Investigation; A Journal Of Technical Methods And Pathology. Vol. 89, no. 11. (November): e1243.
Hans CP; Zerfaoui M; Naura AS; Troxclair D; Strong JP; Matrougui K; Boulares AH. 2009. Thieno[2,3-c]isoquinolin-5-one, a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-deficient mice: effects on inflammatory markers and lipid content. The Journal Of Pharmacology And Experimental Therapeutics. Vol. 329, no. 1. (April): e150.
Naura AS; Datta R; Hans CP; Zerfaoui M; Rezk BM; Errami Y; Oumouna M; Matrougui K; Boulares AH. 2009. Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia. The European Respiratory Journal: Official Journal Of The European Society For Clinical Respiratory Physiology. Vol. 33, no. 2. (February): e252.
Hans CP; Feng Y; Naura AS; Zerfaoui M; Rezk BM; Xia H; Kaye AD; Matrougui K; Lazartigues E; Boulares AH. 2009. Protective effects of PARP-1 knockout on dyslipidemia-induced autonomic and vascular dysfunction in ApoE mice: effects on eNOS and oxidative stress. Plos One. Vol. 4, no. 10. (January): ee7430.
Hans CP; Zerfaoui M; Naura AS; Catling A; Boulares AH. 2008. Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability. Cardiovascular Research. Vol. 78, no. 3. (June): e429.
Naura AS; Hans CP; Zerfaoui M; You D; Cormier SA; Oumouna M; Boulares AH. 2008. Post-allergen challenge inhibition of poly(ADP-ribose) polymerase harbors therapeutic potential for treatment of allergic airway inflammation. Clinical And Experimental Allergy: Journal Of The British Society For Allergy And Clinical Immunology. Vol. 38, no. 5. (May): e839.
Zerfaoui M; Suzuki Y; Naura AS; Hans CP; Nichols C; Boulares AH. 2008. Nuclear translocation of p65 NF-kappaB is sufficient for VCAM-1, but not ICAM-1, expression in TNF-stimulated smooth muscle cells: Differential requirement for PARP-1 expression and interaction. Cellular Signalling. Vol. 20, no. 1. (January): e186.
Oumouna-Benachour K; Hans CP; Suzuki Y; Naura A; Datta R; Belmadani S; Fallon K; Woods C; Boulares AH. 2007. Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death. Circulation. Vol. 115, no. 18. (May): e2442.
Oumouna M; Datta R; Oumouna-Benachour K; Suzuki Y; Hans C; Matthews K; Fallon K; Boulares H. 2006. Poly(ADP-ribose) polymerase-1 inhibition prevents eosinophil recruitment by modulating Th2 cytokines in a murine model of allergic airway inflammation: a potential specific effect on IL-5. Journal Of Immunology (Baltimore, Md.: 1950). Vol. 177, no. 9. (November): e6489.
Hans CP; Chaudhary DP; Bansal DD. 2003. Effect of magnesium supplementation on oxidative stress in alloxanic diabetic rats. Magnesium Research: Official Organ Of The International Society For The Development Of Research On Magnesium. Vol. 16, no. 1. (March): e13.
Hans CP; Chaudhary DP; Bansal DD. 2002. Magnesium deficiency increases oxidative stress in rats. Indian Journal Of Experimental Biology. Vol. 40, no. 11. (November): e1275.