Cheryl E. Gariepy, MD

Cheryl E. Gariepy, MD, is an attending pediatric gastroenterologist at Nationwide Children’s, a Principal Investigator in the Center for Molecular and Human Genetics in the Research Institute at Nationwide Children’s, and an Associate Professor of Pediatrics at The Ohio State University College of Medicine. She has received NIH funding for her research program focusing on the molecular signals controlling development of the enteric nervous system. She is the Motility and Functional GI Disorders Committee Liaison to the North American Society for Pediatric Gastroenterology and Nutrition Research Committee, on the editorial board of the Journal of Pediatric Gastroenterology and Nutrition, and active in the Collaborative Alliance for Pancreatic Education and Research. She has published numerous research articles, presented at international meetings, and authored several book chapters. Dr. Gariepy is named among the “Best Doctors in America.”

Her clinical interests include congenital abnormalities of the gastrointestinal tract and genetic diseases of the intestine, pancreas and liver.

Gender:

• Female

Languages Spoken:

• English

Research Center:

• Center for Molecular and Human Genetics

Areas of Interest:

• The Gariepy lab studies the development of the enteric (intestinal) nervous system (ENS) using and animal model of the most common developmental abnormality of the ENS, Hirschsprung disease. Hirschsprung disease is the congenital absence of a portion of the ENS. It occurs in approximately 1 in 5000 births worldwide and leads to neonatal intestinal obstruction and death. Treatment consists of surgical removal of the affected intestine. Hirschsprung disease is the underlying diagnosis in 7% of small bowel transplants in the United States. Disabling symptoms caused by chronic alteration of ENS function occur in many disease. These include diabetic neuropathy, post-infections irritable bowel syndrome, schlerodema, disorders of the central nervous system (such as cerebral palsy, Parkinson’s disease and Alzheimers disease), amyloidosis, porphyria, Chagas disease, mitochondrial cytopathies, inflammatory bowel disease (Crohn’s disease and ulcerative colitis), congenital anomalies of the intestine, and necrotizing enterocolitis. Selective neurodegeneration in the ENS may also occur with aging and contribute to the increased frequency of constipation, dysphagia and gastroesophageal reflux seen in the elderly. Through improved understanding of the normal development and structure of the ENS and through the isolation and characterization of the stem cells of the ENS, we hope to contribute to improved diagnosis and treatment of these conditions. Mutation in many different genes has been linked to normal development of the ENS. The most common of these are in the tyrosine kinase receptor RET and the G-protein coupled receptor EDNRB. The ENS is derived from neural crest cells that invade the foregut and colonize the developing intestine in a cranial to caudal progression. Dr. Gariepy has shown that EDNRB expression on the neural crest cells is critical for normal colonization of the distal gut. She has also demonstrated that the EDNRB-deficient Hirschsprung rat harbors ENS stem cells in the proximal intestine. How the two receptors interact to support normal ENS development and how mutations in RET and EDNRB impair the ability of the ENS precursors remains unclear. We are interested in understanding the mechanisms controlling normal ENS development using a variety of molecular biologic, histologic, physiologic, and survival surgical techniques. We are examining the intracellular and extracellular events triggered by activation of RET and EDNRB on ENS stem cells which we can isolate prospectively from the rat intestine. We are also working to establish the therapeutic potential of ENS stem cells in disorders of the ENS through transplantation.

Undergraduate School

• Univeristy of Michigan
  Date Completed: 06/30/1985

Medical School

• Stanford University
  Date Completed: 06/15/1990

Internship

• Children's Medical Center of Dallas
  Date Completed: 06/30/1991

Residency

• Children's Medical Center of Dallas
  Date Completed: 06/30/1993

Fellowship

• University of Texas Southwestern Medical Center
  Date Completed: 08/31/1996

Fellowship

• Laboratory of Masashi Yanagisawa, MD, PhD - Howard Hughes Medical Institute
  Date Completed: 06/30/1999

Fellowship

• University of Texas Southwestern Medical Center
  Date Completed: 08/31/1999

Department:

• Pediatrics

Section:

• Gastroenterology/Nutrition

Speciality:

• Pediatric Gastroenterology
  

Date of Appointment at Nationwide Children’s Hospital:

• 03/02/2009

2009–present

• Member of the editorial board of The Journal of Pediatric Gastroenterology and Nutrition

2009–present

• Member, Division of Pediatric Gastroenterology, Nationwide Children’s Hospital, Columbus, Ohio

2009–present

• Associate Professor of Pediatric Gastroenterology, The Ohio State University, Columbus, Ohio

2008–present

• GI Representative to The Council of the Society for Pediatric Research 

2006–2008

• Co-director of the Pediatric Gastroenterology Fellowship Training Program, University of Michigan

2001–2008

• Assistant Professor of Pediatric Gastroenterology, University of Michigan, Ann Arbor, Michigan

2000–2003

• Research Committee, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

1999–2001

• Assistant Professor of Pediatric Gastroenterology and Nutrition, University of Texas Southwestern Medical Center at Dallas, Texas

• Kumar,Soma; Gariepy,Cheryl,E; Crandall,Wallace. 2012. Nutritional Management of Pediatric Acute Pancreatitis.  GASTROENTEROLOGY. Vol. 142, no. 5. (May): S707-S708.
• Ciciora,Steven,L; Gariepy,Cheryl,E. 2012. The Effects of Amoxicillin and Clavulanic Acid on the Spontaneous Mechanical Activity of Juvenile Rat Duodenum.  GASTROENTEROLOGY. Vol. 142, no. 5. (May): S380-S380.
• Gisser,Jonathan,M; Gariepy,Cheryl,E. 2012. Endothelin-3 is a Potent Regulator of Retinoic Acid Metabolism in Cultured Enteric Nervous System Precursors.  GASTROENTEROLOGY. Vol. 142, no. 5. (May): S332-S332.
• Gisser JM and Gariepy CE. 2012. Genetics of Motility Disorders: Gastroesophageal Reflux, Triple A, Hirschsprung’s Disease and Chronic Intestinal Pseudo-Obstruction. In Pediatric Neurogastroenterology: Gastrointestinal Mitility and Functional Disorders in Children. Edited by Christophe Faure M.D., Carlo Di Lorenzo M.D., Nikhil Thapar M.D. New York: Springer.
• Gariepy CE. Human/Clinical genetics | Hirschsprung's Disease. In Brenner’s Online Encyclopedia of Genetics, 2nd Edition. Edited by Stanley Maloy and Kelly Hughes.
• Perez M and Gariepy CE. 2011. Schwachman-Diamnond Syndrome. In NASPGHAN Fellow’s Concise Review of Pediatric Gastroenterology, Hepatology and Nutrition. Edited by J Sondheimer and CW Hurtado. New York: Castle Connolly Graduate Medical Publishing, Ltd.
• Perez M and Gariepy CE. 2011. Congenital Pancreatic Anomalies. In NASPGHAN Fellow’s Concise Review of Pediatric Gastroenterology, Hepatology and Nutrition. Edited by J Sondheimer and CW Hurtado. New York: Castle Connolly Graduate Medical Publishing, Ltd.
• Perez M and Gariepy CE. 2011. Acute Pancreatitis. In NASPGHAN Fellow’s Concise Review of Pediatric Gastroenterology, Hepatology and Nutrition. Edited by J Sondheimer and CW Hurtado. New York: Castle Connolly Graduate Medical Publishing, Ltd.
• Tsai YH, Murakami N, and Gariepy CE. 2011. Postnatal intestinal engraftment of prospectively selected enteric neural crest stem cells in a rat model of Hirschsprung disease.  NEUROGASTROENTEROLOGY AND MOTILITY. Vol. 23, no. 4. (April): 362-369.
• Perez M, and Gariepy CE. 2011. Acute Pancreatitis. In NASPGHAN Fellow’s Concise Review of Pediatric Gastroenterology, Hepatology and Nutrition. Edited by Sondheimer, J; Hurtado, C. W. New York, NY: Castle Connolly Graduate Medical Publishing, Ltd.
• Perez M, and Gariepy CE. 2011. Congenital Pancreatic Anomalies. In NASPGHAN Fellow’s Concise Review of Pediatric Gastroenterology, Hepatology and Nutrition. Edited by Sondheimer, J; Hurtado C.W.. New York, NY: Castle Connolly Graduate Medical Publishing, Ltd.
• Perez M, and Gariepy CE. 2011. Schwachman-Diamnond Syndrome. In NASPGHAN Fellow’s Concise Review of Pediatric Gastroenterology, Hepatology and Nutrition. Edited by Sondheimer, J; Hurtado, C. W.. New York, NY: Castle Connolly Graduate Medical Publishing, Ltd.
• Gariepy,Cheryl,E; Mousa,Hayat. 2009. Clinical management of motility disorders in children.  SEMINARS IN PEDIATRIC SURGERY. Vol. 18, no. 4. (November): 224-238.
• Gariepy CE, and Mousa H. 2009. Clinical management of motility disorders in children.  SEMINARS IN PEDIATRIC SURGERY. Vol. 18, no. 4. (November): 224-238.
• Tykocki NR, Gariepy CE, and Watts SW. 2009. Endothelin ETB Receptors in Arteries and Veins: Multiple Actions in the Vein.  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. Vol. 329, no. 3. (June): 875-881.
• Thakali K, Galligan JJ, Fink GD, Gariepy CE, and Watts SW. 2008. Pharmacological endothelin receptor interaction does not occur in veins from ETB receptor deficient rats.  VASCULAR PHARMACOLOGY. Vol. 49, no. 1. (July): 6-13.
• Makita S, Henry M, Gariepy CE, Yanagisawa M, and Ginty DD. 2008. Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons.  NATURE. Vol. 452, no. 7188. (April): 759-U8.
• Gariepy CE. 2008. Introduction to Endothelin-3/Endothelin-B Receptor and Sox10 Signaling Pathways. In Molecular Basis of Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis. Edited by Charles J. Epstein, Robert P. Erickson, Anthony Wynshaw-Boris. New York: Oxford University Press.
• Imseis E, and Gariepy CE. 2008. Hirschsprung Disease. In Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis, and Management. city...: BC Decker Inc..
• Rangwalla,Sujal; Gariepy,Cheryl,E. 2007. Review.  Gastroenterology & hepatology. Vol. 3, no. 3. (March): 211-226.
• Rangwalla S, and Gariepy CE. 2007. Invited Reveiw of MEN2B.  Gastroenterology & hepatology. Vol. 3, no. 3. (March): 211-226.
• Berti-Mattera LN, Gariepy CE; Burke RM, and Hall AK. 2006. Reduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetes.  EXPERIMENTAL NEUROLOGY. Vol. 201, no. 2. (October): 399-406.
• Tsai YH, Ohkita M, and Gariepy CE. 2006. Chronic high-sodium diet increases aortic wall endothelin-1 expression in a blood pressure-independent fashion in rats.  EXPERIMENTAL BIOLOGY AND MEDICINE. Vol. 231, no. 6. (June): 813-817.
• Dickinson CJ and Gariepy CE. 2006. Translation and Posttranslational Processing of GI Peptides. In Physiology of Gastroinestinal Tract. Fourth ed. Edited by Leonard Johnson. San Diego: Elsevier.
• Tsai YH, and Gariepy CE. 2005. Dynamic changes in the proximal gut neural crest stem cell population are associated with successful development of the distal enteric nervous system in rats.  PEDIATRIC RESEARCH. Vol. 58, no. 4. (October): 636-643.
• Ohkita M, Wang YQ, Nguyen NDT, Tsai YH, Williams SC, Wiseman RC, Killen PD, Li SJ, Yanagisawa M, and Gariepy CE. 2005. Extrarenal ETB plays a significant role in controlling cardiovascular responses to high dietary sodium in rats.  HYPERTENSION. Vol. 45, no. 5. (May): 940-946.
• Yamamoto S, Matsumoto N, Kanazawa M, Fujita M, Takaoka M, Gariepy CE, Yanagisawa M, and Matsumura Y. 2005. Different contributions of endothelin-A and endothelin-B receptors in postischemic cardiac dysfunction and norepinephrine overflow in rat hearts.  CIRCULATION. Vol. 111, no. 3. (January): 302-309.
• Tazawa N, Okada Y, Nakata M, Izumoto H, Takasu M,Takaoka M, Gariepy CE, Yanagisawa M, and Matsumura Y. 2004. Exaggerated vascular and renal pathology in endothelin-B-receptor-deficient rats with subtotal nephrectomy.  JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. Vol. 44, no. November: S467-S470.
• Nishida M, Okada Y, Akiyoshi K, Eshiro K, Takaoka M, Gariepy CE, Yanagisawa M, and Matsumura Y. 2004. Role of endothelin ETB receptor in the pathogenesis of monocrotaline-induced pulmonary hypertension in rats.  EUROPEAN JOURNAL OF PHARMACOLOGY. Vol. 496, no. 1-3. (August): 159-165.
• Gariepy CE. 2004. Developmental disorders of the enteric nervous system: Genetic and molecular bases.  JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. Vol. 39, no. 1. (July): 5-11.
• Gariepy,C,E. 2004. Developmental disorders of the enteric nervous system: Genetic and molecular bases.  JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. Vol. 39, no. 1. (July): 5-11.
• Okada Y, Nakata M, Izumoto H, Takasua M, Tazawa N, Takaoka M, Gariepy CE, Yanagisawa M, and Matsumura Y. 2004. Role of endothelin ETB receptor in partial ablation-induced chronic renal failure in rats.  EUROPEAN JOURNAL OF PHARMACOLOGY. Vol. 494, no. 1. (June): 63-71.
• Yamamoto S, Matsumoto N, Kanazawa M, Fujita M, Takaoka M, Gariepy CE, Yanagisawa M, and Matsumura Y. 2004. Role of endothelin Eta and Etb receptor in the ischemia/reperfusion-induced cardiac dysfunction and norepinephrine overflow of isolated rat hearts.  Journal of Pharmacological Sciences. Vol. 94, no. Supplement 1. (January): e271P.
• Gariepy CE, and Yanagisawa M. 2004. The Endothelin Signaling Pathway - Introduction to Endothelin-3/Endothelin-B Receptor and SOX10 Signaling Pathways. In Oxford Monographs on Medical Genetics. Edited by Epstein, Charles J; Erickson, Robert P; Wynshaw-Boris, Anthony. New York: OXFORD UNIV PRESS.
• Gariepy, Cheryl E., Yanagisawa, M. 2004. Introduction to Endothelin-3/Endothelin B Receptor and Sox10 Signaling Pathways. In In Molecular Basis of Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis. Edited by Chares J. Epstein, Robert P. Erickson, Anthony Wynshaw-Boris. New York: Oxford University Press.
• Imseis E, and Gariepy CE. 2004. Hirschsprung Disease. In Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis, and Management. Edited by W. Allan Walker. city...: BC Decker Inc..
• Riechers CC, Knabe W, Siren AL, Gariepy CE,Yanagisawa M, and Ehrenreich H. 2004. Endothelin B receptor deficient transgenic rescue rats: A rescue phenomenon in the brain.  NEUROSCIENCE. Vol. 124, no. 4. (January): 719-723.
• Kruger GM, Mosher JT, Tsai TH, Yeager KJ, Iwashita T, Gariepy CE, and Morrison SJ. 2003. Temporally distinct requirements for endothelin receptor B in the generation and migration of gut neural crest stem cells.  NEURON. Vol. 40, no. 5. (December): 917-929.
• Gariepy CE. 2003. Genetic basis of Hirschsprung disease: implications in clinical practice.  MOLECULAR GENETICS AND METABOLISM. Vol. 80, no. 1-2. (September): 66-73.
• Gariepy,C,E. 2003. Genetic basis of Hirschsprung disease: implications in clinical practice.  MOLECULAR GENETICS AND METABOLISM. Vol. 80, no. 1-2. (September): 66-73.
• Taylor T, Gariepy CE, Pollock DM, and Pollock JS. 2003. Gender differences in ET and NOS systems in ETB receptor deficient rats: Effect of a high salt diet.  HYPERTENSION. Vol. 41, no. 2. (March): 657-662.
• Taylor TA, Gariepy CE, Pollock DM, and Pollock JS. 2003. Unique endothelin receptor binding in kidneys of ETB receptor deficient rats.  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. Vol. 284, no. 3. (March): R674-R681.
• Konishi F, Okada Y, Takaoka M, Gariepy CE, Yanagisawa M, and Matsumura Y. 2002. Role of endothelin ETB receptors in the renal hemodynamic and excretory responses to big endothelin-1.  EUROPEAN JOURNAL OF PHARMACOLOGY. Vol. 451, no. 2. (September): 177-184.
• Nangaku M, Yamada K, Gariepy CE, Miyata T, Inagi R, Kurokawa K, Yanagisawa M, Fujita T, and JOHNSON RJ. 2002. ETB receptor protects the tubulointerstitium in experimental thrombotic microangiopathy.  KIDNEY INTERNATIONAL. Vol. 62, no. 3. (September): 922-928.
• Ivy DD, Yanagisawa M, Gariepy CE, Gebb SA, Colvin KL, and McMurtry IF. 2002. Exaggerated hypoxic pulmonary hypertension in endothelin B receptor-deficient rats.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 282, no. 4. (April): L703-L712.
• Keljo DJ, and Gariepy CE. 2002. Anatomy and Developmental Anomalies of the Small and Large Intestine. In Sleisenger & Fortrans' Gastrointestinal and Liver Disease. Seventh ed. Edited by Mark Feldman, Lawrence S. Friedman, Marvin H. Sleisenger. Philadelphia: W.B. Saunders.
• Gariepy,C,E. 2001. Intestinal motility disorders and development of the enteric nervous system.  PEDIATRIC RESEARCH. Vol. 49, no. 5. (May): 605-613.
• Ivy DD, McMurtry IF, Yanagisawa M, Gariepy CE, Le Cras TD, Gebb SA, Morris KG, Wiseman RC, and Abman SH. 2001. Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 280, no. 5. (May): L1040-L1048.
• Gariepy CE. 2001. Intestinal motility disorders and development of the enteric nervous system.  PEDIATRIC RESEARCH. Vol. 49, no. 5. (May): 605-613.
• Gariepy, Cheryl E. 2001. Intestinal motility disorders and development of the enteric nervous system.  Pediatric Research. Vol. 49, no. 5. (January): 605-613.
• Pollock DM, Portik-Dobos V, Procter C, Gariepy, CE, and Yanagisawa M. 2000. Arterial pressure response to endothelin-1 and sarafotoxin in 6c in rescued endothelin-B-deficient rats.  JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. Vol. 36, no. 5 S1. (November): S82-85.
• Matsumura Y, Kuro T, Kobyashi Y, Konishi F, Takaoka M, Wessale JL, Opgenorth TJ, Gariepy, CE, and Yanagisawa M. 2000. Increased susceptibility to deoxycorticosterone acetate-salt-induced hypertension in endothelin-B-deficient rats.  JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. Vol. 36, no. S1. (November): S86-89.
• Matsumura Y, Kuro T, Kobayashi Y, Konishi F, Takoaka M, Wessale JL, Opgenorth TJ, Gariepy CE, and Yanagisawa M. 2000. Exaggerated vascular and renal pathology in endothelin-B receptor-deficient rats with deoxycorticosterone acetate-salt hypertension.  CIRCULATION. Vol. 102, no. 22. (November): 2765-2773.
• Ohuchi,T; Yanagisawa,M; Gariepy,C,E. 2000. Renal tubular effects of endothelin-B receptor signaling: its role in cardiovascular homeostasis and extracellular volume regulation.  CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION. Vol. 9, no. 4. (July): 435-439.
• Gariepy CE, Ohuchi T, Williams SC, Richardson JA, and Yanagisawa M. 2000. Salt-sensitive hypertension in endothelin-B receptor-deficient rats.  JOURNAL OF CLINICAL INVESTIGATION. Vol. 105, no. 7. (April): 925-933.
• Matsumura Y; Kuro T; Konishi F; Takaoka M, Gariepy CE, and Yanagisawa M. 2000. Enhanced blood pressure sensitivity to DOCA-salt treatment in endothelin ETB receptor-deficient rats.  BRITISH JOURNAL OF PHARMACOLOGY. Vol. 129, no. 6. (March): 1060-1062.
• Ohuchi T, Yanagisawa M, and Gariepy CE. 2000. Renal tubular effects of endothelin-B receptor signaling: its role in cardiovascular homeostasis and extracellular volume regulation.  Current Opinion in Nephrology and Hypertension. Vol. 9, no. 4. (January): 435-439.
• Gariepy CE, Williams SC Richardson JA Hammer RE, and Yanagisawa M. 1998. Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease.  JOURNAL OF CLINICAL INVESTIGATION. Vol. 102, no. 6. (September): 1092-1101.
• Gariepy CE, Cass DT, and Yanagisawa M. 1996. Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Vol. 93, no. 2. (January): 867-872.
• Gariepy CE, Lomax MI, and Grossman LI. 1986. SPLINT - A CUBIC SPLINE INTERPOLATION PROGRAM FOR THE ANALYSIS OF FRAGMENT SIZES IN ONE-DIMENSIONAL ELECTROPHORESIS GELS.  NUCLEIC ACIDS RESEARCH. Vol. 14, no. 1. (January): 575-581.
• Ciciora SL and Gariepy CE. Hirschsprung Disease. In Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis, and Management 6th Edition. Edited by R.E. Kleinman, O.J. Goulet, G. Mieli-Vergani, I.R. Sanderson, P.M. Sherman and B.L Schneider.
• Saha M and Gariepy CE. Introduction to Endothelin-B Receptor and Sox10 Signaling Pathways. In Molecular Basis of Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis. Edited by Epstein CJ, Erickson RP, Wynshaw-Boris A.
• Gisser, J. and Gariepy, Cheryl E. Genetics of Motility Disorders: Gastroesophageal Reflux, Triple A. Hirschsprung’s Disease, and Chronic Intestinal Pseudo-Obstruction.  Pediatric Neurogastroenterlogy: Gastrointestinal Motility and Functional Disorders in Children.
• Gariepy, Cheryl E. Human/Clinical Genetics/Hirschsprung’s Disease.  Brenner’s Online Encyclopedia of Genetics, 2nd Edition.