Cheryl E. Gariepy, MD

Dr. Gariepy is an attending pediatric gastroenterologist at Nationwide Children’s, a Principal Investigator in the Center for Cell and Developmental Biology in the Research Institute at Nationwide Children’s and an Associate Professor of Pediatrics at The Ohio State University College of Medicine. She has received funding from the National Institutes of Health for her research program focusing on the molecular signals controlling development of the nervous system in the intestines. She is the Gastroenterology representative to the Council of the Society for Pediatric Research and a member of the editorial board of the Journal of Pediatric Gastroenterology and Nutrition. She has published numerous research articles, presented her research at international meetings, and authored several book chapters. These include chapters in Sleisenger & Fortrans’ Gastrointestinal and Liver Disease; Molecular Basis of Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis; Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis, and Management; and Physiology of the Gastrointestinal Tract. Dr. Gariepy is named among the “Best Doctors in America.” Her clinical interests include congenital abnormalities of the gastrointestinal tract and genetic disease.

Gender:

• Female

Languages Spoken:

• English

Research Center:

• Center for Molecular and Human Genetics

Areas of Interest:

• The Gariepy lab studies the development of the enteric (intestinal) nervous system (ENS) using and animal model of the most common developmental abnormality of the ENS, Hirschsprung disease. Hirschsprung disease is the congenital absence of a portion of the ENS. It occurs in approximately 1 in 5000 births worldwide and leads to neonatal intestinal obstruction and death. Treatment consists of surgical removal of the affected intestine. Hirschsprung disease is the underlying diagnosis in 7% of small bowel transplants in the United States. Disabling symptoms caused by chronic alteration of ENS function occur in many disease. These include diabetic neuropathy, post-infections irritable bowel syndrome, schlerodema, disorders of the central nervous system (such as cerebral palsy, Parkinson’s disease and Alzheimers disease), amyloidosis, porphyria, Chagas disease, mitochondrial cytopathies, inflammatory bowel disease (Crohn’s disease and ulcerative colitis), congenital anomalies of the intestine, and necrotizing enterocolitis. Selective neurodegeneration in the ENS may also occur with aging and contribute to the increased frequency of constipation, dysphagia and gastroesophageal reflux seen in the elderly. Through improved understanding of the normal development and structure of the ENS and through the isolation and characterization of the stem cells of the ENS, we hope to contribute to improved diagnosis and treatment of these conditions. Mutation in many different genes has been linked to normal development of the ENS. The most common of these are in the tyrosine kinase receptor RET and the G-protein coupled receptor EDNRB. The ENS is derived from neural crest cells that invade the foregut and colonize the developing intestine in a cranial to caudal progression. Dr. Gariepy has shown that EDNRB expression on the neural crest cells is critical for normal colonization of the distal gut. She has also demonstrated that the EDNRB-deficient Hirschsprung rat harbors ENS stem cells in the proximal intestine. How the two receptors interact to support normal ENS development and how mutations in RET and EDNRB impair the ability of the ENS precursors remains unclear. We are interested in understanding the mechanisms controlling normal ENS development using a variety of molecular biologic, histologic, physiologic, and survival surgical techniques. We are examining the intracellular and extracellular events triggered by activation of RET and EDNRB on ENS stem cells which we can isolate prospectively from the rat intestine. We are also working to establish the therapeutic potential of ENS stem cells in disorders of the ENS through transplantation.

Undergraduate

• Univeristy of Michigan
  Date Completed: 06/30/1985

Medical School

• Stanford University
  Date Completed: 06/15/1990

Internship

• Children's Medical Center of Dallas
  Date Completed: 06/30/1991

Residency

• Children's Medical Center of Dallas
  Date Completed: 06/30/1993

Fellowship

• University of Texas Southwestern Medical Center
  Date Completed: 08/31/1996

Fellowship

• Laboratory of Masashi Yanagisawa, MD, PhD - Howard Hughes Medical Institute
  Date Completed: 06/30/1999

Fellowship

• University of Texas Southwestern Medical Center
  Date Completed: 08/31/1999

Department:

• Pediatrics

Section:

• Gastroenterology/Nutrition

Speciality:

• Pediatric Gastroenterology, Certified
  
• Pediatrics
  

Date of Appointment at Children's Hospital:

• 03/02/2009

2009–present

• Member of the editorial board of The Journal of Pediatric Gastroenterology and Nutrition

2009–present

• Member, Division of Pediatric Gastroenterology, Nationwide Children’s Hospital, Columbus, Ohio

2009–present

• Associate Professor of Pediatric Gastroenterology, The Ohio State University, Columbus, Ohio

2008–present

• GI Representative to The Council of the Society for Pediatric Research 

2006–2008

• Co-director of the Pediatric Gastroenterology Fellowship Training Program, University of Michigan

2001–2008

• Assistant Professor of Pediatric Gastroenterology, University of Michigan, Ann Arbor, Michigan

2000–2003

• Research Committee, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

1999–2001

• Assistant Professor of Pediatric Gastroenterology and Nutrition, University of Texas Southwestern Medical Center at Dallas, Texas

• Cheryl E. Gariepy. 2012. Human/Clinical genetics | Hirschsprung's Disease. In Brenner?s Online Encyclopedia of Genetics, 2nd Edition. Edited by Stanley Maloy and Kelly Hughes. Oxford, UK: Elsevier/Academic Press. (Formally Accepted)
• Gisser J. and Gariepy, C.E. 2011. Genetics of Motility Disorders: Gastroesophageal Reflux, Triple A. Hirschsprung?s Disease, and Chronic Intestinal Pseudo-Obstruction.  Pediatric Neurogastroenterlogy: Gastrointestinal Motility and Functional Disorders in Children. (Unspecified)
• Cheryl E. Gariepy. 2011. Human/Clinical Genetics/Hirschsprung?s Disease.  Brenner?s Online Encyclopedia of Genetics, 2nd Edition.. (Formally Accepted)
• Jonathan Gisser and Cheryl E. Gariepy. 2011. Genetics of Motility Disorders: Gastroesophageal Reflux, Triple A, Hirschsprung?s Disease and Chronic Intestinal Pseudo-Obstruction. In Pediatric Neurogastroenterology: Gastrointestinal Mitility and Functional Disorders in Children. Edited by Christophe Faure M.D., Carlo Di Lorenzo M.D., Nikhil Thapar M.D. New York, NY: Springer. (Formally Accepted)
• Tsai, Y-H, Murakami, N., Gariepy, C.E. 2010. Postnatal intestinal engraftment of prospectively selected enteric neural crest stem cells in a rat model of Hirschsprung disease.  Neurogastroenterology and Motility. no. e-published ahead of print. (December 29) (IF: 3.568)
• Gariepy CE; Mousa H. 2009. Clinical management of motility disorders in children.  Seminars In Pediatric Surgery. Vol. 18, no. 4. (November 1): 224.
• Gariepy, Cheryl E. and Hayat Mousa. 2009. Clinical management of motility disorders in children.  Seminars in Pediatric Surgery. Vol. 18, no. 4 (November): 224-238.
• Tykocki NR; Gariepy CE; Watts SW. 2009. Endothelin ET(B) receptors in arteries and veins: multiple actions in the vein.  The Journal Of Pharmacology And Experimental Therapeutics. Vol. 329, no. 3. (June 1): 875.
• Tykocki, Nathan R.; Gariepy, Cheryl E.; Watts, Stephanie W. 2009. Endothelin Etb Receptors in Arteries and Veins: Multiple Actions in the Vein.  Journal of Pharmacology and Experimental Therapeutics. Vol. 329, no. 3: 875-881.
• Thakali K; Galligan JJ; Fink GD; Gariepy CE; Watts SW. 2008. Pharmacological endothelin receptor interaction does not occur in veins from ET(B) receptor deficient rats.  Vascular Pharmacology. Vol. 49, no. 1. (July 1): 6.
• Makita T; Sucov HM; Gariepy CE; Yanagisawa M; Ginty DD. 2008. Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons.  Nature. Vol. 452, no. 7188. (April 10): 759.
• Makita, Takako; Sucov, Henry M.; Gariepy, Cheryl E.; Yanagisawa, Masashi; Ginty, David D. 2008. Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons.  Nature (London). Vol. 452, no. 7188: 759.
• Thakali, Keshari; Galligan, James J.; Fink, Gregory D.; Gariepy, Cheryl E.; Watts, Stephanie W. 2008. Pharmacological endothelin receptor interaction does not occur in veins from Etb receptor deficient rats.  Vascular Pharmacology. Vol. 49, no. 1: 6-13.
• Gariepy, Cheryl E.. 2008. Introduction to Endothelin-3/Endothelin-B Receptor and Sox10 Signaling Pathways. In Molecular Basis of Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis. Edited by Charles J. Epstein, Robert P. Erickson, Anthony Wynshaw-Boris. New York, NY: Oxford University Press. 521-529.
• Imseis, E., and Gariepy, Cheryl E.. 2008. Hirschsprung Disease. In Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis, and Management. city..: BC Decker Inc. 683-691.
• Berti-Mattera LN; Gariepy CE; Burke RM; Hall AK. 2006. Reduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetes.  Experimental Neurology. Vol. 201, no. 2. (October 1): 399.
• Tsai YH; Ohkita M; Gariepy CE. 2006. Chronic high-sodium diet increases aortic wall endothelin-1 expression in a blood pressure-independent fashion in rats.  Experimental Biology And Medicine (Maywood, N.J.). Vol. 231, no. 6. (June 1): 813.
• Tsai, Yu-Hwai; Ohkita, Mamoru; Gariepy, Cheryl E.. 2006. Chronic high-sodium diet increases aortic wall endothelin-1 expression in a blood pressure-independent fashion in rats.  Experimental Biology and Medicine (Maywood). Vol. 231, no. 6: 813-817.
• Berti-Mattera, Liliana N.; Gariepy, Cheryl E.; Burke, Rebecca M.; Hall, Alison K. 2006. Reduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetes.  Experimental Neurology. Vol. 201, no. 2: 399-406.
• Dickinson, C.J. and Gariepy, Cheryl E.. 2006. Translation and Posttranslational Processing of GI Peptides. In Physiology of Gastroinestinal Tract. Fourth ed. Edited by Leonard Johnson. San Diego, CA: Elsevier. 31-61.
• Tsai YH; Gariepy CE. 2005. Dynamic changes in the proximal gut neural crest stem cell population are associated with successful development of the distal enteric nervous system in rats.  Pediatric Research. Vol. 58, no. 4. (October 1): 636.
• Ohkita M; Wang Y; Nguyen ND; Tsai YH; Williams SC; Wiseman RC; Killen PD; Li S; Yanagisawa M; Gariepy CE. 2005. Extrarenal ETB plays a significant role in controlling cardiovascular responses to high dietary sodium in rats.  Hypertension. Vol. 45, no. 5. (May 1): 940.
• Yamamoto S; Matsumoto N; Kanazawa M; Fujita M; Takaoka M; Gariepy CE; Yanagisawa M; Matsumura Y. 2005. Different contributions of endothelin-A and endothelin-B receptors in postischemic cardiac dysfunction and norepinephrine overflow in rat hearts.  Circulation. Vol. 111, no. 3. (January 25): 302.
• Ohkita, Mamoru; Wang, Yuqin; Nguyen, Ngoc Diep T.; Tsai, Yu-Hwai; Williams, S. Clay; Wiseman, Richard C.; Killen, Paul D.; Li, Shujun; Yanagisawa, Masashi; Gariepy, Cheryl E.. 2005. Extrarenal Etb plays a significant role in controlling cardiovascular responses to high dietary sodium in rats.  Hypertension (Baltimore). Vol. 45, no. 5: 940-946.
• Tazawa N; Okada Y; Nakata M; Izumoto H; Takasu M; Takaoka M; Gariepy CE; Yanagisawa M; Matsumura Y. 2004. Exaggerated vascular and renal pathology in endothelin-B-receptor-deficient rats with subtotal nephrectomy.  Journal Of Cardiovascular Pharmacology. Vol. 44 Suppl 1. (November 1): S467.
• Nishida M; Okada Y; Akiyoshi K; Eshiro K; Takoaka M; Gariepy CE; Yanagisawa M; Matsumura Y. 2004. Role of endothelin ETB receptor in the pathogenesis of monocrotaline-induced pulmonary hypertension in rats.  European Journal Of Pharmacology. Vol. 496, no. 1-3. (August 2): 159.
• Gariepy CE. 2004. Developmental disorders of the enteric nervous system: genetic and molecular bases.  Journal Of Pediatric Gastroenterology And Nutrition. Vol. 39, no. 1. (July 1): 5.
• Okada Y; Nakata M; Izumoto H; Takasu M; Tazawa N; Takaoka M; Gariepy CE; Yanagisawa M; Matsumura Y. 2004. Role of endothelin ETB receptor in partial ablation-induced chronic renal failure in rats.  European Journal Of Pharmacology. Vol. 494, no. 1. (June 21): 63.
• Nishida, Masahiro; Okada, Yuka; Akiyoshi, Kenji; Eshiro, Keiko; Takaoka, Masanori; Gariepy, Cheryl E.; Yanagisawa, Masashi; Matsumura, Yasuo. 2004. Role of endothelin Etb receptor in the pathogenesis of monocrotaline-induced pulmonary hypertension in rats.  European Journal of Pharmacology. Vol. 496, no. 1-3: 159-165.
• Gariepy, Cheryl E., Yanagisawa, M. 2004. Introduction to Endothelin-3/Endothelin B Receptor and Sox10 Signaling Pathways. In Molecular Basis of Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis. Edited by Chares J. Epstein, Robert P. Erickson, Anthony Wynshaw-Boris. New York, NY: Oxford University Press. 433-439.
• Imseis, E., and Gariepy, Cheryl E.. 2004. Hirschsprung Disease. In Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis, and Management. Edited by W. Allan Walker. city..: BC Decker Inc. 1032-1043.
• Riechers, C. -C.; Knabe, W.; Siren, A. -L.; Gariepy, Cheryl E.; Yanagisawa, M.; Ehrenreich, H. 2004. Endothelin B receptor deficient transgenic rescue rats: A rescue phenomenon in the brain.  Neuroscience. Vol. 124, no. 4: 719-723.
• Yamamoto, Satoshi; Matsumoto, Noriko; Kanazawa, Mitsuo; Fujita, Marie; Takaoka, Masanori; Gariepy, Cheryl E.; Yanagisawa, Masashi; Matsumura, Yasuo. 2004. Role of endothelin Eta and Etb receptor in the ischemia/reperfusion-induced cardiac dysfunction and norepinephrine overflow of isolated rat hearts.  Journal of Pharmacological Sciences. Vol. 94, no. Supplement 1: 271P.
• Gariepy, Cheryl E.; Yanagisawa, Masashi. 2004. The Endothelin Signaling Pathway - Introduction to Endothelin-3/Endothelin-B Receptor and SOX10 Signaling Pathways. In Oxford Monographs on Medical Genetics. Edited by Epstein, Charles J; Erickson, Robert P; Wynshaw-Boris, Anthony. New York: OXFORD UNIV PRESS.
• Riechers CC; Knabe W; Sirén AL; Gariepy CE; Yanagisawa M; Ehrenreich H. 2004. Endothelin B receptor deficient transgenic rescue rats: a rescue phenomenon in the brain.  Neuroscience. Vol. 124, no. 4. (January 1): 719.
• Gariepy, Cheryl E.. 2004. Developmental disorders of the enteric nervous system: Genetic and molecular bases.  JPGN Journal of Pediatric Gastroenterology and Nutrition. Vol. 39, no. 1: 5-11.
• Okada, Yuka; Nakata, Mariko; Izumoto, Hiromi; Takasua, Mai; Tazawa, Naoko; Takaoka, Masanori; Gariepy, Cheryl E.; Yanagisawa, Masashi; Matsumura, Yasuo. 2004. Role of endothelin Etb receptor in partial ablation-induced chronic renal failure in rats.  European Journal of Pharmacology. Vol. 494, no. 1: 63-71.
• Kruger GM; Mosher JT; Tsai YH; Yeager KJ; Iwashita T; Gariepy CE; Morrison SJ. 2003. Temporally distinct requirements for endothelin receptor B in the generation and migration of gut neural crest stem cells.  Neuron. Vol. 40, no. 5. (December 4): 917.
• Gariepy CE. 2003. Genetic basis of Hirschsprung disease: implications in clinical practice.  Molecular Genetics And Metabolism. Vol. 80, no. 1-2. (September 1): 66.
• Taylor TA; Gariepy CE; Pollock DM; Pollock JS. 2003. Gender differences in ET and NOS systems in ETB receptor-deficient rats: effect of a high salt diet.  Hypertension. Vol. 41, no. 3 Pt 2. (March 1): 657.
• Taylor TA; Gariepy CE; Pollock DM; Pollock JS. 2003. Unique endothelin receptor binding in kidneys of ETB receptor deficient rats.  American Journal Of Physiology. Regulatory, Integrative And Comparative Physiology. Vol. 284, no. 3. (March 1): R674.
• Taylor, Traci A.; Gariepy, Cheryl E.; Pollock, David M.; Pollock, Jennifer S. 2003. Unique endothelin receptor binding in kidneys of Etb receptor deficient rats.  American Journal of Physiology. Vol. 284, no. 3 Part 2: R674-R681.
• Gariepy, Cheryl E.. 2003. Genetic basis of Hirschsprung disease: Implications in clinical practice.  Molecular Genetics and Metabolism. Vol. 80, no. 1-2: 66-73.
• Taylor, Traci A.; Gariepy, Cheryl E.; Pollock, David M.; Pollock, Jennifer S. 2003. Gender differences in Et and Nos systems in Etb receptor-deficient rats: Effect of a high salt diet.  Hypertension (Baltimore). Vol. 41, no. 3 Part 2: 657-662.
• Kruger, Genevieve M.; Mosher, Jack T.; Tsai, Yu-Hwai; Yeager, Kelly J.; Iwashita, Toshihide; Gariepy, Cheryl E.; Morrison, Sean J. 2003. Temporally distinct requirements for Endothelin receptor B in the generation and migration of gut neural crest stem cells.  Neuron. Vol. 40, no. 5: 917-929.
• Konishi F; Okada Y; Takaoka M; Gariepy CE; Yanagisawa M; Matsumura Y. 2002. Role of endothelin ET(B) receptors in the renal hemodynamic and excretory responses to big endothelin-1.  European Journal Of Pharmacology. Vol. 451, no. 2. (September 13): 177.
• Nangaku M; Yamada K; Gariepy CE; Miyata T; Inagi R; Kurokawa K; Yanagisawa M; Fujita T; Johnson RJ. 2002. ET(B) receptor protects the tubulointerstitium in experimental thrombotic microangiopathy.  Kidney International. Vol. 62, no. 3. (September 1): 922.
• Ivy DD; Yanagisawa M; Gariepy CE; Gebb SA; Colvin KL; McMurtry IF. 2002. Exaggerated hypoxic pulmonary hypertension in endothelin B receptor-deficient rats.  American Journal Of Physiology. Lung Cellular And Molecular Physiology. Vol. 282, no. 4. (April 1): L703.
• Ivy, D. Dunbar; Yanagisawa, Masashi; Gariepy, Cheryl E.; Gebb, Sarah A.; Colvin, Kelley L.; McMurtry, Ivan F. 2002. Exaggerated hypoxic pulmonary hypertension in endothelin B receptor-deficient rats.  American Journal of Physiology. Vol. 282, no. 4 Part 1: L703-L712.
• Konishi, Fumiko; Okada, Yuka; Takaoka, Masanori; Gariepy, Cheryl E.; Yanagisawa, Masashi; Matsumura, Yasuo. 2002. Role of endothelin Etb receptors in the renal hemodynamic and excretory responses to big endothelin-1.  European Journal of Pharmacology. Vol. 451, no. 2: 177-184.
• Keljo, D.J. and Gariepy, Cheryl E.. 2002. Anatomy and Developmental Anomalies of the Small and Large Intestine. In Sleisenger & Fortrans' Gastrointestinal and Liver Disease. Seventh ed. Edited by Mark Feldman, Lawrence S. Friedman, Marvin H. Sleisenger. Philadelphia, PA: W.B. Saunders. 1643-1663.
• Nangaku, Masaomi; Yamada, Koei; Gariepy, Cheryl E.; Miyata, Toshio; Inagi, Reiko; Kurokawa, Kiyoshi; Yanagisawa, Masashi; Fujita, Toshiro; Johnson, Richard J. 2002. Etb receptor protects the tubulointerstitium in experimental thrombotic microangiopathy.  Kidney International. Vol. 62, no. 3: 922-928.
• Gariepy CE. 2001. Intestinal motility disorders and development of the enteric nervous system.  Pediatric Research. Vol. 49, no. 5. (May 1): 605.
• Ivy D; McMurtry IF; Yanagisawa M; Gariepy CE; Le Cras TD; Gebb SA; Morris KG; Wiseman RC; Abman SH. 2001. Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction.  American Journal Of Physiology. Lung Cellular And Molecular Physiology. Vol. 280, no. 5. (May 1): L1040.
• Ivy, D. Dunbar; McMurtry, Ivan F.; Yanagisawa, Masashi; Gariepy, Cheryl E.; Le Cras, Timothy D.; Gebb, Sarah A.; Morris, Kenneth G.; Wiseman, Richard C.; Abman, Steven H. 2001. Endothelin B receptor deficiency potentiates Et-1 and hypoxic pulmonary vasoconstriction.  American Journal of Physiology. Vol. 280, no. 5 Part 2: L1040-L1048.
• Gariepy, Cheryl E.. 2001. Intestinal motility disorders and development of the enteric nervous system.  Pediatric Research. Vol. 49, no. 5: 605-613.
• Matsumura Y; Kuro T; Kobayashi Y; Konishi F; Takaoka M; Wessale JL; Opgenorth TJ; Gariepy CE; Yanagisawa M. 2000. Exaggerated vascular and renal pathology in endothelin-B receptor-deficient rats with deoxycorticosterone acetate-salt hypertension.  Circulation. Vol. 102, no. 22. (November 28): 2765.
• Pollock DM; Portik-Dobos V; Procter C; Gariepy CE; Yanagisawa M. 2000. Arterial pressure response to endothelin-1 and sarafotoxin 6c in rescued endothelin-B-deficient rats.  Journal Of Cardiovascular Pharmacology. Vol. 36, no. 5 Suppl 1. (November 1): S82.
• Matsumura Y; Kuro T; Kobayashi Y; Konishi F; Takaoka M; Wessale JL; Opgenorth TJ; Gariepy CE; Yanagisawa M. 2000. Increased susceptibility to deoxycorticosterone acetate-salt-induced hypertension in endothelin-B-receptor-deficient rats.  Journal Of Cardiovascular Pharmacology. Vol. 36, no. 5 Suppl 1. (November 1): S86.
• Ohuchi T; Yanagisawa M; Gariepy CE. 2000. Renal tubular effects of endothelin-B receptor signaling: its role in cardiovascular homeostasis and extracellular volume regulation.  Current Opinion In Nephrology And Hypertension. Vol. 9, no. 4. (July 1): 435.
• Gariepy CE; Ohuchi T; Williams SC; Richardson JA; Yanagisawa M. 2000. Salt-sensitive hypertension in endothelin-B receptor-deficient rats.  The Journal Of Clinical Investigation. Vol. 105, no. 7. (April 1): 925.
• Matsumura Y; Kuro T; Konishi F; Takaoka M; Gariepy CE; Yanagisawa M. 2000. Enhanced blood pressure sensitivity to DOCA-salt treatment in endothelin ET(B) receptor-deficient rats.  British Journal Of Pharmacology. Vol. 129, no. 6. (March 1): 1060.
• Matsumura, Yasuo; Kuro, Toshihiko; Kobayashi, Yutaka; Konishi, Fumiko; Takaoka, Masanori; Wessale, Jerry L.; Opgenorth, Terry J.; Gariepy, Cheryl E.; Yanagisawa, Masashi. 2000. Exaggerated vascular and renal pathology in endothelin-b receptor-deficient rats with deoxycorticosterone acetate-salt hypertension.  Circulation. Vol. 102, no. 22: 2765-2773.
• Pollock, David M.; Portik-Dobos, Vera; Procter, Charles; Gariepy, Cheryl E.; Yanagisawa, Masashi. 2000. Arterial pressure response to endothelin-1 and sarafotoxin 6c in rescued endothelin-b-deficient rats.  Journal of Cardiovascular Pharmacology. Vol. 36, no. 5 Supplement 1: S82-S85.
• Gariepy, Cheryl E.; Ohuchi, Takashi; Williams, S. Clay; Richardson, James A.; Yanagisawa, Masashi. 2000. Salt-sensitive hypertension in endothelin-b receptor-deficient rats.  Journal of Clinical Investigation. Vol. 105, no. 7: 925-933.
• Matsumura, Yasuo; Kuro, Toshihiko; Konishi, Fumiko; Takaoka, Masanori; Gariepy, Cheryl E.; Yanagisawa, Masashi. 2000. Enhanced blood pressure sensitivity to Doca-salt treatment in endothelin Etb receptor-deficient rats.  British Journal of Pharmacology. Vol. 129, no. 6: 1060-1062.
• Matsumura, Yasuo; Kuro, Toshihiko; Kobayashi, Yutaka; Konishi, Fumiko; Takaoka, Masanori; Wessale, Jerry L.; Opgenorth, Terry J.; Gariepy, Cheryl E.; Yanagisawa, Masashi. 2000. Increased susceptibility to deoxycorticosterone acetate-salt-induced hypertension in endothelin-b-receptor-deficient rats.  Journal of Cardiovascular Pharmacology. Vol. 36, no. 5 Supplement 1: S86-S89.
• Gariepy CE; Williams SC; Richardson JA; Hammer RE; Yanagisawa M. 1998. Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease.  The Journal Of Clinical Investigation. Vol. 102, no. 6. (September 15): 1092.
• Gariepy, Cheryl E.; Williams, S. Clay; Richardson, James A.; Hammer, Robert E.; Yanagisawa, Masashi. 1998. Transgenic expression of the endothelin-b receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease.  Journal of Clinical Investigation. Vol. 102, no. 6: 1092-1101.
• Gariepy CE; Cass DT; Yanagisawa M. 1996. Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color.  Proceedings Of The National Academy Of Sciences Of The United States Of America. Vol. 93, no. 2. (January 23): 867.
• Gariepy, Cheryl E.; Cass, Daniel T.; Yanagisawa, Masashi. 1996. Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color.  Proceedings of the National Academy of Sciences of the United States of America. Vol. 93, no. 2: 867-872.
• Gariepy CE; Lomax MI; Grossman LI. 1986. SPLINT: a cubic spline interpolation program for the analysis of fragment sizes in one-dimensional electrophoresis gels.  Nucleic Acids Research. Vol. 14, no. 1. (January 10): 575.
• Gariepy, Cheryl E., Lomax, M.I., and Grossman, L.I. 1986. Splint: a cubic spline interpolation program for the analysis of fragment sizes in one dimensional electrophoresis gels.  Nucleic Acids Res. no. 14: 575-581.
• Cheryl E. Gariepy, Chair. 1999. The endothelin-B receptor-deficient rat model of salt-sensitive hypertension. to Vascular Biology Center. Medical College of Georga. Augusta, GA, USA. (June 14)
• M. Li, Poster Presenter. 2007. S-6c-induced hypertension is largely mediated through direct venoconstriction in female rats. Presented at Experimental Biology. Washington, D.C., USA. [Peer Reviewed]
• M. Li. 2007. S6c-induced hypertension in endothelin-B receptor-deficient rats:evidence that the endothelin-B receptor affects sypathetic control of blood pressure. Presented at American Heart Association's Council for High Blood Pressure Research Scientific Sessions. Orlando, FL, USA. (November 5)
• Cheryl E. Gariepy, Chair. 1999. Salt-sensitive hypertension in endothelin-B receptor-deficient rats. Presented at Sixth International Conference on Endothelin. Montreal, Quebec, Canada. (October 11)
• Cheryl E. Gariepy, Presenter. 2002. ETB receptors extrinsic to the kidney prevent salt-induced hypertension in rats. Presented at Physiology Seminar. University of Michigan. Ann Arbor, MI, USA. (April 18)
• Cheryl E. Gariepy, Presenter. 2003. Persistence of neural crest stem cells in the proximal gut of the Hirschsprung rat. Presented at Annual Meeting of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Montreal, Quebec, Canada. (October 4)
• Cheryl E. Gariepy, Presenter. 2003. Neural crest stem cels are maintained in the proximal gut in a rat model of Hirschsprung disease. Presented at 14th Annual Research day suyposium and the 44th Annual Mid-West Society for Pediatric Research Scientific Meeting. University of Michigan. Ann Arbor, MI, USA. (October 17)
• X. Dai, Poster Presenter. 2007. ETB receptors contribute to venous but not arterial constriction caused to endothelin-1: A study using ETB receptor-deficient rats. Presented at American Heart Association's Council for High Blood Pressure Research Scientific Sessions. Orlando, FL, USA. [Peer Reviewed]
• Cheryl E. Gariepy, Presenter. 1997. Adult rats deficient in endothelin-B receptors produced via tissue-specific transgenic rescue. Presented at Fifth International Conference on Endothelin. Kyoto, Japan. (September 15)
• Cheryl E. Gariepy, Presenter. 2002. Mechanism extrinsic to the kidney contribute to salt-induced hypertension in ETB-deficient rats. Presented at Experimental Biology 2002. New Orleans, LA, USA. (April 20)
• Cheryl E. Gariepy, Presenter. 1999. Transgenic expression of the endothelin-B receptor supports normal ENS development in the Hirschsprung rat. Presented at Gastroenterology basic science research conference. Department of Internal Medicine, University of Texas Southwestern Medical Center. Dallas, TX, USA. (June 18)
• M Ohkita, Presenter. 2005. ETA blockade prevents polydipsia in volume expanded, hypertensive Wistar-Kyoto rats on high-salt diet. Presented at Ninth International Conference on Endothelin. Park City, UT, USA. [Peer Reviewed]
• X. Yang, Poster Presenter. 2001. Media acidification stimulated endothelin-1 synthesis and receptor binding in OKP cells. Presented at World Congress of Nephrology. San Fancisco, CA, USA. [Peer Reviewed]
• Y-H Tsai, Presenter. 2005. Enteric nerual crest stem cells transplanted into the post-natal gut in vivo produce cells expressing neuronal and glial markers. Presented at 16th Annual Pediatric Research Symposium. University of Michigan. Ann Arbor, MI, USA. (November 8)
• Cheryl E. Gariepy, Presenter. 2003. Central ETA-mediated mechanisms and increased sympathetic activity contribute to salt-sensitive hypertension in ETB-deficient rats. Presented at Eigth International Conference on Endothelin. Tsukuba, Japan. (November 26)
• Cheryl E. Gariepy, Presenter. 2002. Signaling downstream of the endothelin-B receptor in the developing enteric nervous system. Presented at 13th Annual Pediatric Research Symposium. University of Michigan. Ann Arbor, MI, USA. (October 18)
• Cheryl E. Gariepy, Presenter. 2000. Role of the endothelin system in ENS development. Presented at Peurach Family Workshop on Congenital Intestinal Psudo-obstruction. Newport Beach, CA, USA. (March 25)
• Cheryl E. Gariepy, Presenter. 2010. Development and the Potential for Therapeutic Repair of the Enteric Nervous System. Presented at Pediatric Surgery Basic Science Conference. Nationwide Children's Hospital. Columbus, OH, USA. (April 14)
• Cheryl E. Gariepy, Presenter. 1999. A transgenic approach to the development of an ETB-deficient rat. Presented at Department of Molecular Genetic Research Presentations (Brown and Goldstein conference). University of Texas Southwestern Medical Center. Dallas, TX, USA. (July 20)
• Cheryl E. Gariepy, Presenter. 2010. RET and EDNRB signaling in the developing ENS and the potential for therapeutic repair. Presented at Developmental Genetics Research Seminar Series. Columbus, OH, USA. (February 25)
• Cheryl E. Gariepy, Presenter. 1999. Rodent genetic models and the role of the endothelin system in cardiovascular homeostasis. Presented at 72nd Scientific Sessions of the American Heart Association. Atlanta, GA, USA. (November 7)
• Cheryl E. Gariepy, Presenter. 2010. Role of Ret and EDNRB signaling in enteric nervous system development. Presented at Department of Pharmacology Seminar. Ohio State University. Columbus, OH, USA. (February 27)
• Cheryl E. Gariepy, Presenter. 1998. Transgenic expression of the endothelin-B receptor prevents intestinal aganglionosis in a rat model of Hirschsprung disease. Presented at Meeting of predoctoral and physician postdoctoral fellows of the Howard Hughes Medical Institute. Chevy Chase, MD, USA. (September 25)
• Cheryl E. Gariepy, Presenter. 2001. Renal transplantation in ETB-deficient salt-sensitive rats. Presented at Vascular Biology Club. University of Texas Southwestern Medical Center. Dallas, TX, USA. (August 25)
• Cheryl E. Gariepy, Lecturer. 2010. Neonatal constipation in the term and preterm infant. Presented at American Academy of Pediatrics 76th Perinatal and Developmental Medicine Symposium, to AAP Section on Perinatal Pediatrics. Hotel Jerome. Aspen, CO, USA. (June 11) [Peer Reviewed]
• K. Thakali, Poster Presenter. 2008. Rat thoracid vena cava ETB receptors re-sensitize faster than venous ETA receptors. Presented at Experimental Biology. San Diego, CA, USA. [Peer Reviewed]
• Cheryl E. Gariepy, Presenter. 1998. Endothelin pathway in the development of the ENS. Presented at Keystone symposium on Molecular and Cellular Biology- Enteric Nervous System. Santa Fe, NM, USA. (June 6)
• Cheryl E. Gariepy, Chair. 1999. ETB-deficient, salt-sensitive rats. Presented at Vascular biology club. University of Texas Southwestern Medical Center. Dallas, TX, USA. (September 22)
• Cheryl E. Gariepy, Presenter. 2002. Role of the endothelin-B receptor in ENS development. Presented at Research Seminar Series. Department of Molecular, Cellular and Craniofacial Biology, Birth Defects Center, University of Louisville. Louisville, KY, USA. (September 15)
• Cheryl E. Gariepy, Presenter. 1995. The role of endothelins in pigment cell biology. Presented at Pan-American Society of Pigment Cell Research. Kansas, City, MO. (June 26)
• Cheryl E. Gariepy, Presenter. 1995. Null mutation in the endothelin-B receptor gene produces Hirschsprung disease in the rat. Presented at Annual meeting of the North American Society for Pediatric Gastroenterology and Nutrition. Chicago, IL, USA. (November 18)
• M. Li, Presenter. 2007. S6c-induced hypertension in endothelin-B receptor-deficient rats: Evidence that endothelin-B receptor affects sympathetic control of blood pressure. Presented at American Heart Association's Council for High Blood Pressure Research Scientific Sessions. Orlando, FL, USA. [Peer Reviewed]
• Cheryl E. Gariepy, Presenter. 2008. Development and therapeutic repair of the enteric nervous system. to Research Institute. Nationwide Children's Hospital. Columbus, OH, USA. (March 8)
• Bradley K. Yoder, Moderator. 2010. State of the Art Lecture: Emerging Role of Cilia in Development and Disease. Presented at Digestive Disease Week, to The Growth, Development and Aging Section of the AGA. New Orleans, LA, USA. (May 3) [Peer Reviewed]
• Cheryl E. Gariepy, Presenter. 2002. Salt-sensitive hypertension in ETB-deficient rats is due to mechanisms not intrinsic to the kidney. Presented at 23rd Annual Regional Hypertension Workshop. Kellogg Biological Station. Battle Creek, MI, USA. (May 3)
• Cheryl E. Gariepy, Presenter. 2003. Neural crest stem cells are absent in the distal gut of the Hirschsprung rat. Presented at Michigan Gut Peptide Research Center Symposium. University of Michigan. Ann Arbor, MI, USA. (January 20)
• Cheryl E. Gariepy, Presenter. 2005. Chronic high-sodium diet increases aortic wall ET1 protein and mRNA in a blood pressure-independent fashion in Wistar-Kyoto rats. Presented at Ninth International Conference on Endothelin. Park City, UT, USA. (September 12)
• S. H. Yoon, Poster Presenter. 2004. Essential role of endothelin B receptors in subarachnoid hemorrhage induced vasospasm. Presented at Experiemental Biology. Washington, D.C., USA. [Peer Reviewed]
• Cheryl E. Gariepy, Chair. 2001. Transgenic expression of the endothelin-B receptor allows complete ENS development in the Hirschsprung rat. Presented at Department of Pediatrics Faculty Research Conference. University of Texas Southwestern Medical Center. Dallas, TX, USA. (February 26)
• Cheryl E. Gariepy, Presenter. 1999. The endothelin-B receptor in development and adult homeostasis. University of Michigan. Ann Arbor, MI, USA. (April 8)
• Cheryl E. Gariepy, Presenter. 1999. Transgenic rescue of the Hirschsprung rat. Presented at Annual Meeting of the North American Society for Pediatric Gastroenterology and Nutrition. Toronto, Ontario, Canada. (November 19)
• Cheryl E. Gariepy, Presenter. 2008. Development and therapeutic repair of the enteric nervous system. to University of Texas Southwestern Medical Center Deparment of Pediatrics. Dallas, TX, USA. (June 6)
• Cheryl E. Gariepy, Presenter. 2001. Salt-sensitivity as a consequence of ETB deficiency. Presented at Department of Nephrology Research Conference. University of Texas Southwestern Medical Center. Dallas, TX, USA. (May 10)
• X. Dai, Poster Presenter. 2007. ETB receptors contribute to venous but not arterial constriction caused to ET-1; studies using ETB receptor-deficient rats. Presented at Experimental Biology. Washington, D.C., USA. [Peer Reviewed]
• J. Fandino, Poster Presenter. 2002. Endothelin B receptor null mutation prevents subarachnoid hemorrhage induced ceregral vasospasm in the rat in vivo. Presented at Annual meeting of the Congress of Neurological Surgeons. Philidelphia, PA, USA. [Peer Reviewed]
• M. Li, Poster Presenter. 2008. Hypertension in male ETB-receptor deficient rats is not mediated by splanchnic sympathetic nerves. Presented at Experimental Biology. San Diago, CA, USA. [Peer Reviewed]
• J. Xie, Poster Presenter. 2003. Differential gene expression in the developing intestine of wild-typ and ETB knock-out embryos studies by Affymetrix GeneChip analysis. Presented at Eigth International Conference on Endothelin. Tsukuba, Japan. [Peer Reviewed]
• Cheryl E. Gariepy, Presenter. 2010. Isoloation of ENS stem cells. Presented at Center for Molecular and Human Genetics Seminar Series. Nationwide Children's Research Institute. Columbus, OH, USA. (April 12)
• Cheryl E. Gariepy, Lecturer. 2010. Development of the Enteric Nervous System and Potential for Therapeutic Repair. Presented at American Academy of Pediatrics 76th Perinatal and Developmental Medicine Symposium, to AAP Section on Perinatal Pediatrics. Hotel Jerome. Aspen, CO, USA. (June 12) [Peer Reviewed]
• E. Imseis, Poster Presenter. 2002. The critical role of endothelin-2 in growth and survival of the neonatal mouse. Presented at 13th Annual Pediatric Research Symposium. University of Michigan. Ann Arbor, MI, USA. [Peer Reviewed]
• Cheryl E. Gariepy, Presenter. 2005. The endothelin system's role in physiologic responses to high dietary sodium. Presented at Nephrology Basic Science Series. University of Michigan. Ann Arbor, MI, USA. (October 11)
• Cheryl E. Gariepy, Presenter. 1998. The endothelin system in development of the ENS. Presented at NIH workshop on motility of the digestive tract. Bethesda, MD, USA. (June 17)
• Cheryl E. Gariepy, Presenter. 2004. Temporal and region-specific abnormalities in enteric nervous system stem cell development in the Hirschsprung rat. Presented at 15th annual Pediatric Research Symposium. University of Michigan. Ann Arbor, MI, USA. (October 1)