Director: Pamela A. Lucchesi, PhD
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Faculty: |
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The Heart Center Co-Directors
Rebecca Anderson – Clinical Research Coordinator
I
have a BA in Communication from Capital University. I came to work in
the Heart Center here at Nationwide Children’s two years ago and
recently made the move over to Research. I help physicians submit
research studies, talk to patients and organize data. I am looking
forward to learning and growing along with our Center as we look to the
future.
Diane M. Carver – Operations Manager
As
Operations Manager I coordinate all Center process improvement
initiatives; present, monitor, and analyze fiscal data; and work with
The Heart Center, Children’s Foundation, and our community partners to
communicate and expand our research talents within the Center for
Cardiovascular & Pulmonary Research. I received my BA in
Communications from Capital University and my Masters degree in Public
Administration from The University of Akron. I have experience in both
non-profit and government organizations in the areas of fund
development, fiscal and policy analysis, program development and
evaluation, and Continuous Quality Improvement. I’m excited to be part
of the Center as we move forward; leading pediatric cardiology research
in the US and abroad.
Anuradha Guggilam – Postdoctoral Student
I
graduated in May 2009 from Louisiana State University and my doctoral
dissertation involved studying the role of TNF induced oxidative stress
in the autonomic regulatory centers of the brain in the progression of
ischemic heart failure. My new projects in Lucchesi’s lab link my
clinical training as a veterinarian and my graduate school experience
in cardiovascular physiology to conduct heart failure related research
in rodents and pigs. My current research aims at understanding the
myocyte sarcomere assembly and Ca++ homeostasis in volume overload
heart failure model. This project will help delineate the precise
functional and structural alterations the myocytes undergo in response
to volume overload as well as to surgical closure of the shunt. My
other research interests include micro RNAs and their relevance in
heart failure pathogenesis.
Bing Han – Post Doctoral
I
have a PhD degree from the College of Pharmacy at the Ohio State
University. I have been focusing on research projects in cardiovascular
disease. Currently, I am working in the Giannone Lab. My focus is the
prenatal imprint on cardiovascular system. We are studying the impact
of prenatal inflammation and preterm delivery on cardiac structure,
function and myocardial nitric oxide regulation by using rodent models
Bethany Hashiguchi – Statistical Analyst
I
am currently a PhD student in Sociology at The Ohio State University,
and have four years of experience in sociological and health related
research analysis. In the Center for Cardiovascular and Pulmonary
Research, I assist with study design and statistical analysis. My
research interests are social and racial stratification, including
disparities in health/healthcare by income and race.
Hong Huang – Research Scientist
I
received my MD degree from Beijing Medical University, Beijing, China,
and my PhD degree in pharmacology from The Ohio State University.
Cardiovascular disease is my primary research interest, from animal
models to translational research. My current research includes
endothelial biology and signaling; developing mouse models of pre-natal
and peri-natal inflammation induced cardiovascular dysfunction;
clinical studies regarding effects of secondhand smoke exposure on
vascular function in children; and management of the heart center
tissue bank.
Kirk Hutchinson – Research Assistant
I
am from New Orleans, Louisiana and left hurricane country with my wife
and two little girls to work with Dr. Pamela Lucchesi at Nationwide
Children’s. I am currently a graduate student working on my PhD in
Pharmacology. My research involves determining the extent to which
reactive oxygen species regulate cardiac fibroblasts and how this
affects heart function in volume overload heart failure. I use
isolated cells as well as in vivo functional assessments to correlate
the contributions of fibroblasts to heart function.
Selvi Jeyaraj – Postdoctoral Student
I
received my Ph.D. from the Molecular, Cellular and Developmental
Biology Program at The Ohio State University. My doctoral studies, in
the lab of Dr. Beth Lee, investigated the regulation of the RNA binding
protein HuR in response to renal ischemia/reperfusion injury. I am a
member of the Lab of Dr. Maqsood Chotani at The Research Institute at
Nationwide Children’s Hospital and will be studying the role of the
small G protein, Rap1 in the cardiovasculature and in stress responsive
signaling.
Paige S. Katz – Research Assistant
I
am currently a PhD student in the Physiology Department at Louisiana
State University. Currently, I am studying how type 2 diabetes affects
coronary artery remodeling in the db/db mouse model.
Sara Koenig – Research Assistant
I
received my BA in biology with a minor in chemistry from Ohio Wesleyan
University in June 2009. As an undergraduate student, I worked in a
molecular genetics lab that focused on nonsense-mediated mRNA decay
(NMD) as a type of post-transcriptional regulation using S. pombe as a
model system. As a Research Assistant in Dr. Vidu Garg’s laboratory in
the Center for Cardiovascular and Pulmonary Research, I am currently
involved in human genetic studies specifically using array comparative
genomic hybridization to identify novel copy number variations in
children with cardiac malformations.
Mary McAllister – Research Aide
I
am currently a first year undergraduate student at the University of
Notre Dame. I am in the Pre Med/ Pre Professional program with a focus
on Biology and Botany. I am a Research Aide in Dr. Lucchesi’s lab. I
am responsible for preparing solutions, running protein assays, and
assisting the graduate students with their projects. I am interested
in literature, music and running.
Susan Meyer – Research Associate
I
have a BS in Biology from Muskingum College and an MS in Microbiology
from The Ohio State University with eight years experience in contract
research including experimental design, execution and reporting,
project task management, budgeting, scheduling, and presentation to
clients. I also have one year experience in clinical research. My
responsibilities include manuscript editing and submission, grant
preparation, data management, clinical study development, and clinical
study coordination.
Mohammad M. Mofleh - Research Assistant II
I
have a MD degree from University of Damascus, Syria. I currently work
in the Giannone Lab. Our ongoing Research project involves determining
the possible role of both inflammatory factors during pregnancy and
perinatal hypoxia in inducing neonatal necrotizing enterocolitis (NEC)
and identifying the preventive methods by using animal models. I have
a big interest in enriching my overall experience in both basic science
and clinical research.
Juli Richter – Neonatology Fellow
I
received my MD from The Ohio State University of Medicine and Public
Health in 2004. I am now a second year Neonatology Fellow doing the
research portion of my training in the Bauer Lab. Prior to going to
medical school, I received a Pharm.D. from Purdue University in 1994
and worked as a neonatal clinical pharmacist for 6 years. My research
interests include examining the effect that the chronic inflammatory
state of maternal obesity may have on the outcomes of premature infants.
Irene Snyder – Administration
I
have extensive administrative experience and have worked as a Medical
Staff Services Specialist in the Hospital, and as a Clinical
Administration Specialist and a Project Research Coordinator in Project
Services Management with Abbott Laboratories. I support several
Principal Investigators and the personnel in their labs in the Center
for Cardiovascular & Pulmonary Research. Presently I am
coordinating the Center’s Tissue Bank and clinical protocols efforts.
I enjoy reading, and am a Master Gardener.
Aaron J. Trask, PhD – Postdoctoral Fellow
I
earned my PhD in physiology and pharmacology from Wake Forest
University under the tutelage of Dr. Carlos M. Ferrario studying the
involvement of new components of the renin-angiotensin system (RAS) in
hypertension and cardiac hypertrophy. I joined Dr. Pamela Lucchesi at
Nationwide Children’s Hospital as a postdoctoral fellow to expand my
training and interests in the heart by studying the actions of
advanced-glycation end products (AGEs), a major problem in diabetic
cardiomyopathy, on coronary artery structure and function. A secondary
interest of mine is how the actions of AGEs ultimately affect global
cardiac function. These studies will utilize both cell/molecular
techniques, as well as in vivo experiments to discern the involvement
of AGEs and components of the RAS in cardiac dynamics during both the
normal and diabetic states.
Qingqing Wang – Postdoctoral Student
I
received my Ph.D degree in Pediatric Cardiology in July 2007 from
Shandong University College of Medicine in China and my doctoral
dissertation was about the immune tolerance to cardiac myosin induced
by anti-CD4 monoclonal antibody in experimental autoimmune myocarditis.
I had been trained as a postdoctoral fellow for one and a half years in
Dr Yusen Liu’s Lab in the center for Perinatal research focusing on the
immune function of Dusp5, a negative regulator of MAP Kinases. To
further expand my research, I joined Dr John Bauer’s Lab in July 2009
focusing on the immune responses in cardiovascular diseases. I am
extremely interested in both basic and translational research studying
the immune mechanisms of cardiac diseases.
T. Aaron West – Research Associate
I
received my MS thesis in biology from Purdue University in cell biology
and physiology. Prior to joining the Lucchesi Lab I worked in clinical
research, and I’m excited to use all aspects of my background, both
technical and clinical to further the Center’s research.
Jianjing Xue (Shelly) – Research Scientist
I
obtained a Master’s Degree in Molecular Biology and Biochemistry and a
Medical Doctorate from Harbin Medical University in Heilongjiang,
China. I worked for 15 years as a Research Associate in cancer
research, using gene expression and gene therapy approaches. I also
have over eight years of teaching experience in Molecular Biology and
Biochemistry at the level of Associate Professor in Shanghai at the
Second Medical College before moving to the USA. Prior to joining the
Research Institute at Nationwide Children’s Hospital, I worked at The
Ohio State University for 13 years as a Research Associate studying
mechanosensitive signaling pathways in Gastroenterology.
Dane Youtz – Research Assistant
I
recently graduated from Ohio Dominican University with a biology degree
and minor in chemistry. I wanted to get involved with my degree and
delve into research in order to build a stronger resume for medical
school. I am currently applying to get into Ohio University
osteopathic medical school for next fall. I am working for Dr. Loren
Wold and with Dr. Jian Jiang Xue (Shelly) in the cardiovascular
department. My primary field of study is using retrograde perfusion to
isolate rat myocytes (heart cells) and then using an Ionoptix video
system to stimulate the cells using certain voltages. By recording the
length that each cell contracts during a stimulation we can get a
better understanding of how having diabetes or being exposed to fine
particulate matter in the air can directly have an impact on the
controls of the heart. I hope to contribute much to future studies and
able myself to obtain several published works. Other than that I enjoy
doing anything athletic and active, especially playing baseball and
football.
Xiaojin (Jean) Zhang – Research Associate
I
received my bachelor's degree in Medical Science from the Beijing
Medical University and have over 20 years experience as a research
technician/assistant in both basic and clinical research labs. Most
recently I have worked as a senior research assistant in Pharmacology
at the Northeastern Ohio Universities College of Medicine in Rootstown,
OH. My current responsibilities include assisting Dr. Cismowski and
Dr. Lucchesi in developing biomarker assays and assays to analyze
G-protein coupled receptor signal regulation.