The BCR is a CAP-accredited laboratory and biorepository within the Biopathology Center (BPC) at Nationwide Children's Hospital.
The Cancer Driver Discovery Project (CDDP) aims to identify driver mutations that occur in two percent or more of cancer cases. Further explanation of the molecular causes of cancer through deeper characterization of tumors is expected to yield insights into tumor biology, leading to better treatment options. Although a large number of driver genes have been identified through the efforts of TCGA, some tumor types have not been deeply characterized. By sequencing larger numbers of cases, the CDDP will have the statistical power to discover recurrently mutated genes in cancer that may drive the oncogenic process.