Benjamin T. Kopp, MD :: Nationwide Children's Hospital, Columbus, Ohio
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Benjamin T. Kopp, MD

Benjamin T. Kopp, MD

Asthma Program
Physician Team

Center for Microbial Pathogenesis
Principal Investigator

Cystic Fibrosis
Physician Team

Pediatric Pulmonary Fellowship

Pulmonary Medicine
Physician Team

Contact Information

Pulmonary Medicine
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-4766
FX: (614) 722-4755

Location Information for Patients

Main Campus


Benjamin T. Kopp, MD, is a member of the Section of Pulmonary Medicine and a principal investigator for the Center for Microbial Pathogenesis. Dr. Kopp started one of the country’s only pediatric Pulmonary/Sickle Cell combination clinics to treat Sickle Cell Lung Disease in a multi-disciplinary clinic. He is also a member of the Cystic Fibrosis Team and an assistant professor of Pediatrics for The Ohio State University College of Medicine. Dr. Kopp received his undergraduate degree from Miami University, Oxford, Ohio, and went to medical school at The Ohio State University College of Medicine. He completed his residency and fellowship in pediatric pulmonology at Nationwide Children’s Hospital. Dr. Kopp’s research interest involves therapies for cystic fibrosis including early disease mechanisms and improving clearance of chronic bacterial infections (b.cenocepacia), as well as preventing chronic lung disease in patients with Sickle Cell.

View CV »


  • Male

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • The Kopp laboratory focuses on host-pathogen interactions that impact chronic respiratory diseases such as cystic fibrosis (CF) and lung disease related to sickle cell. The two main areas of this research include macrophage signaling and autophagy and their role in controlling infection, as well as biomarkers/pathways of early inflammatory airway disease. The Kopp Lab is in the process of developing novel therapeutics and targets to allow for improved bacterial killing and regulation of hyper-inflammatory signaling.

Education and Training

Medical School

  • Ohio State University College of Medicine
    Date Completed: 06/11/2006


  • Nationwide Children's Hospital
    Date Completed: 06/30/2009


  • Nationwide Children's Hospital
    Date Completed: 06/30/2012


  • Pediatrics


  • Pulmonary Medicine


  • Pediatric Pulmonary Medicine
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 11/30/2010


  • Hayes,Don; Kirkby,Stephen; Whitson,Bryan,A; Black,Sylvester,M; Sheikh,Shahid,I; Tobias,Joseph,D; Mansour,Heidi,M; Kopp,Benjamin,T. 2015. Mortality Risk and Pulmonary Function in Adults With Cystic Fibrosis at Time of Wait Listing for Lung Transplantation.  ANNALS OF THORACIC SURGERY. Vol. 100, no. 2. (August): 474-479.
  • Kopp,Benjamin,T; Nicholson,Lisa; Paul,Grace; Tobias,Joseph; Ramanathan,Chandar; Hayes,Don. 2015. Geographic variations in cystic fibrosis: An analysis of the US CF Foundation Registry.  PEDIATRIC PULMONOLOGY. Vol. 50, no. 8. (August): 754-762.
  • Kopp BT, Sarzynski L, Khalfoun S, Hayes D Jr, Thompson R, Nicholson L, Long F, Castile R, Groner J. 2015. Detrimental effects of secondhand smoke exposure on infants With cystic fibrosis.  Pediatr Pulmonol. Vol. 50, no. 1. (January): 25-34.
  • Hayes D Jr, Daniels CJ, Kirkby S, Kopp BT, Nicholson KL, Nance AE, Splaingard ML. 2014. Polysomnographic differences associated with pulmonary hypertension in patients with advanced lung disease due to cystic fibrosis.  Lung. Vol. 192, no. 3. (June): 413-419.
  • Hayes D Jr, Naguib A, Kirkby S, Galantowicz M, McConnell PI, Baker PB, Kopp BT, Lloyd EA, Astor TL. 2014. Comprehensive evaluation of lung allograft function in infants after lung and heart-lung transplantation.  J Heart Lung Transplant. Vol. 33, no. 5. (May): 507-513.
  • Assani K, Tazi MF, Amer AO, Kopp BT. 2014. IFN-gamma stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages.  PLoS One. Vol. 9, no. 5. (May): ee96681.
  • Limoli DH, Rockel AB, Host KM, Jha A, Kopp BT, Hollis T, Wozniak DJ. 2014. Cationic antimicrobial peptides promote microbial mutagenesis and pathoadaptation in chronic infections.  PLoS Pathog. Vol. 10, no. 4. (April): ee1004083.
  • Hayes D Jr, Kopp BT, Kirkby S, Allen ED, McCoy KS. 2014. Attrition in pediatric pulmonology fellowship.  Pediatr Allergy Immunol Pulmonol. Vol. 27, no. 1. (March): 34-35.
  • Hayes D Jr, Kopp BT, Preston TJ, Kirkby S, Tobias JD, Papadimos TJ, Whitson BA. 2014. Survival of patients with cystic fibrosis on ECMO: analysis of the Extracorporeal Life Support Organization Registry.  Int J Clin Exp Med. Vol. 7, no. 5. (January): 1370-1372.
  • Turner TL, Kopp BT, Paul G, Landgrave LC, Hayes D Jr, Thompson R. 2014. Respiratory syncytial virus: current and emerging treatment options.  Clinicoecon Outcomes Res. Vol. 6, no. January: 217-225.
  • Hayes D Jr, Baker PB, Kopp BT, Kirkby S, Galantowicz M, McConnell PI, Astor TL. 2013. Surveillance transbronchial biopsies in infant lung and heart-lung transplant recipients.  Pediatr Transplant. Vol. 17, no. 7. (November): 670-675.
  • Kopp BT, Kirkby S, Hayes D Jr, Flanigan KM. 2013. Diabetic myonecrosis in a cystic fibrosis patient.  Respir Care. Vol. 58, no. 10. (October): e123-e125.
  • Kopp BT, Hayes D Jr, Ratkiewicz M, Baron N, Splaingard M. 2013. Light exposure and depression in hospitalized adult patients with cystic fibrosis.  J Affect Disord. Vol. 150, no. 2. (September): 585-589.
  • Hayes D Jr, Daniels CJ, Mansour HM, Kopp BT, Yates AR, McCoy KS, Patel AV, Kirkby S. 2013. Right heart catheterization measuring central hemodynamics in cystic fibrosis during exercise.  Respir Med. Vol. 107, no. 9. (September): 1365-1369.
  • Meadows JT Jr, Kopp BT, Shook LA, Ballard HO, Hayes Jr D. 2013. Elevated high-sensitivity C-reactive protein in preterm infants with pulmonary colonization with Ureaplasma.  J Thorac Dis. Vol. 5, no. 3. (June): 223-227.
  • Hayes D Jr, Ramanathan C, Kopp BT. 2012. BMPR2 missense mutation p.K230N and pulmonary arterial hypertension.  Pediatr Pulmonol. Vol. 49, no. 1. (November): e5-e6.
  • Kopp BT, Rosen KL, O'Donovan JC, Sheikh S. 2012. Cardiac fibroma, anomalous pulmonary venous course and persistent pneumonia in a patient with Gorlin syndrome.  Pediatr Pulmonol. Vol. 49, no. 1. (November): e7-e9.
  • Kopp BT, Baron N, Splaingard M. 2012. Lighting up depression in cystic fibrosis.
  • Kopp BT, Abdulrahman BA, Khweek AA, Kumar SB, AkhterA, Montione, R., Tazi MF, Caution K, McCoy K, Amer AO. 2012. Exaggerated inflammatory responses mediated by Burkholderia cenocepacia in human macrophages derived from Cystic fibrosis patients.  Biochem Biophys Res Commun. Vol. 424, no. 2. (July): 221-227.
  • Abdulrahman BA, Abu Khweek A, Caution K, Akhter A, Tazi MF, Kopp BT, Amer AO. 2012. Autophagy stimulation manipulates Burkholderia cenocepacia infection in a cystic fibrosis mouse model. In Experimental Biology Meeting 2012
  • Kopp BT, Wang W, Chisolm DJ, Kelleher KJ, McCoy KS. 2012. Inpatient healthcare trends among adult cystic fibrosis patients in the U.S.  Pediatr Pulmonol. Vol. 47, no. 3. (March): 245-251.
  • Abdulrahman BA, Abu Khweek A, Akhter A, Caution K, Kotrange S, Abdelaziz DH, Newland C, Rosales-Reyes R, Kopp BT, McCoy K, Montione R, Schlesinger LS, Gavrilin MA, Wewers MD, Valvano MA, Amer AO. 2011. Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis.  Autophagy. Vol. 7, no. 11. (November): 1359-1370.
  • Kopp BT, Pastore MT, Sturm AC, Holtzlander MJ, Westman JA. 2011. A novel exon duplication of the cystic fibrosis transmembrane conductance regulator in a patient presenting with adult-onset recurrent pancreatitis.  Pancreas. Vol. 40, no. 5. (July): 773-777.
  • Kotrange S, Kopp BT, Akhter A, Abdelaziz D, Abu Khweek A, Caution K, Abdulrahman B, Wewers M, McCoy K, Marsh C, Loutet SA, Ortega X, Valvano MA, Amer AO. 2011. Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1 beta production in macrophages.  J Leukoc Biol. Vol. 89, no. 3. (March): 481-488.
  • Kopp BT, AbdulRahman B, McCoy KS, Amer AO. 2011. Exaggerated inflammatory responses in human cystic fibrosis macrophages during Burkholderia cenocepacia infection.
  • Kopp BT, Wang W, Chisolm D, Kelleher K, McCoy K. 2011. Inpatient health care trends among adult cystic fibrosis patients in the U.S.
  • Hayes D, Kirkby S, Whiton B, Black SM, Sheikh S, Tobias J, Monsour H, Kopp BT. Mortality risk and pulmonary function in adults with cystic fibrosis at time of wait listing for lung transplantation.  Ann Thorac Surg.
  • Hayes Jr D, Black S, Tobias J, Kopp B, Kirkby S, Mansour H, Whitson B. Influence of HLA mismatching on bronchiolitis obliterans syndrome in lung transplantation.  Journal of Heart and Lung Transplantation.
  • Kopp B, Kirkby S, Hayes D, Flanigan K. "Diabetic myonecrosis in cyscit fibrosis patient.".  Respiratory Care 2013 Jan 29.
  • Kirkby S, Hayes D, Parson J, Wisely C, Kopp BT, McCoy K, Mastronarde J. Eucapnic voluntary hyperventilation to detect exercise-induced bronchoconstriction in cystic fibrosis.  Lung.
  • Kopp B, Hayes D, Ratkiewicz M, Baron N, Splaingard M. "Light exposure and depression in hospitalized adults with cystic fibrosis.".  J Affective Disorders 2013.
  • Kopp BT, Nicholson L, Paul G, Tobias J, Ramanathan C, Hayes D. Geographic variations in cystic fibrosis: an analysis of the U.S. CF registry.  Pediatr Pulmonol.
  • Kopp BT, Groner J, Tobias JD, Whitson BA, Kirkby S, Hayes Jr D. Cigarette smoking impact on survival after lung transplantation in cystic fibrosis.  Exp Clin Transplant.
  • Kopp BT, Hayes Jr D, Ghera P, Patel A, Kirkby S, Kowatch RA, Splaingard M. Pilot Trial of Phototherapy for depression in hospitalized patients with cystic fibrosis.  Jouranl of Affective Disorders.
  • Hayes D Jr, Kopp BT, Tobias JD, Woodley FW, Mansour HM, Tumin D, Kirkby SE. Survival in Patients with Advanced Non-cystic Fibrosis Bronchiectasis Versus Cystic Fibrosis on the Waitlist for Lung Transplantation.  Lung.
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000