BCMM News

Battelle Center for Mathematical Medicine News

 

Researchers Collaborate on Molecular Study on Peptide Tuning of Natural Killer Cells

Jayajit Das, PhD, principal investigator in the Battelle Center for Mathematical Medicine, collaborated with Salim Khakoo, MD, professor of Hepatology at University of Southampton, UK, to understand how natural killer (NK) cells and their receptors operate on a molecular level. Their recent review was featured in Pediatrics Nationwide, a blog published by Nationwide Children's Hospital to advance the conversation on child health among pediatric clinicians and researchers.

Researcher Publishes Innovative Article on Statistical Genetics in Journal Heredity

William Stewart, PhD, principal investigator in the Battelle Center for Mathematical Medicine, published an innovative solution to a problem that stumped statistical geneticists for more than three decades. The article, published online in the June 2016 issue of the journal Heredity, is titled "A Powerful Test of Independent Assortment that Determines Genome-Wide Significance Quickly and Accurately" and includes details on the solution and its implications. 

Post-Doctoral Scientist Receives Travel Award at 15th Annual Trainee Research Day

Sayak Mukherjee, PhD, post-doctoral scientist in the Jayajit Das Lab in the Battelle Center for Mathematical Medicine, received a $1000 Science Travel Award for his poster presentation at the 15th Annual Trainee Research Day, hosted by The Ohio State University College of Medicine. The award will be used by Dr. Mukherjee to attend and present his research (the same project presented at Trainee Research Day) at a scientific meeting of his choice. Dr. Mukherjee's project is entitled "Reconstruction of Single Cell Signaling Trajectories Using Cytometry Data."

Researcher Presented with Dr. Elizabeth L. Gross Award for Faculty Excellence

William C. Ray, PhD, principal investigator in the Battelle Center for Mathematical Medicine, received the Dr. Elizabeth L. Gross Faculty Award for excellence in mentoring, teaching, research, service and his numerous contributions to the Biophysics Program at The Ohio State University. Dr. Ray was selected as the award winner by students at The Ohio State University and received the award on April 15, 2016.

Article Published in Special Statistical Significance Issue of Journal Entropy

Veronica Vieland, PhD, director of the Battelle Center for Mathematical Medicine, and Sang-Cheol Seok, PhD, systems programmer in the Vieland Lab, had an article published in the open-access journal Entropy in March 2016. The article is titled "Statistical Evidence Measured on a Properly Calibrated Scale for Multinomial Hypothesis Comparisons" and was published in the special issue, Statistical Significance and the Logic of Hypothesis Testing.

Biophysical Journal Publication and KITP Quantitative Immunology Workshop Invitation

Jayajit Das, PhD, principal investigator in the Battelle Center for Mathematical Medicine, recently had a paper ("Limiting Energy Dissipation Induces Glassy Kinetics in Single Cell High Precision Responses" accepted for publication in the Biophysical Journal. Dr. Das was also invited to participate at the Kavli Institute for Theoretical Physics (KITP) workshop on quantitative immunology, which was held February 1-19, 2016.

>> Read the publication abstract.

Researcher Co-Organizes Mathematical Biosciences Workshop at The Ohio State University

The Mathematical Biosciences Institute of The Ohio State University hosted a Current Topic Workshop on "Modeling and Inference from Single Molecules to Cells" from February 8-12, 2016. Jayajit Das, PhD, principal investigator in the Battelle Center for Mathematical Medicine, was one of four co-organizers for the workshop.

>> Learn more about the workshop.

Collaborative Research on Thermocyte Selection Published in Journal eLife

Jayajit Das, PhD, prinicipal investigator in the Battelle Center for Mathematical Medicine, recently collaborated with Sayak Mukherjee, PhD, postdoctoral fellow in the Das Lab at the Battelle Center for Mathematical Medicine, and Karsten Sauer, PhD, from the Scripps Institute, on a project on thermocyte selection. The paper, entitled "Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent," was published in the journal eLife in February 2016.

>> View the abstract and full free text on PubMed.

PLOS ONE Article on Using Linkage Analysis to Detect Gene-Gene Interaction

Susan Hodge, DSc, principal investigator in the Battelle Center for Mathematical Medicine, has recently published a journal article in PLOS ONE, along with colleagues Valerie Hager, PhD, and David Greenberg, PhD, also a principal investigator in BCMM. The article is titled "Using Linkage Analysis to Detect Gene-Gene Interaction in Complex Interaction Models."

>> Access the free full text on PubMed.

Co-Authorship of Article in Physical Biology's Highlights of 2015

Jayajit Das, PhDWilliam C. Ray, PhD, and Veronica Vieland, PhD, all principal investigators in the Battelle Center for Mathematical Medicine, as well as Sayak Mukherjee, PhD, postdoctoral fellow in the Das Lab, and Sang-Cheol Seok, PhD, systems programmer in the Vieland Lab, are co-authors of an article in Physical Biology's Highlights of 2015, published by IOPscience. The article is titled, "Host-to-Host Variation of Ecological Interactions in Polymicrobial Infections" and is free to read online for all of 2016.

>> Read the article for free online.

Postdoctoral Fellow Presents Abstract at Keystone Symposia Conference on "Systems Immunology"

Sayak Mukherjee, PhD, a postdoctoral fellow in the Das Lab in the Battelle Center for Mathematical Medicine, was selected to present his abstract, "Reconstruction of Single Cell Signaling Trajectories using Snapshot Cytometry Data" at the Keystone Symposia Conference on "Systems Immunology" in Big Sky, Montana on January 10-14, 2016. 

>> Learn more on the Keystone Symposia website.

Researchers Discuss Advances in Neuroscience and Genetics of Learning Disabilities

Christopher Bartlett, PhD, a principal investigator in the Battelle Center for Mathematical Medicine, was an invited keynote speaker at the ForLearning International Symposium on Learning Difficulties hosted by the University of Jyvaskula on December 2-4, in Jyvaskula, Finland. Researchers from eleven countries gathered to discuss advances in neuroscience and genetics of learning disabilities. 

>> Read more on the symposium website.

Researcher Publishes Immune Study on "Tuning" of Natural Killer Cells, Critical to Innate Immunity

Jayajit Das, PhD, a principal investigator in the Battelle Center for Mathematical Medicine, published a paper in the September 2015 issue of Immunological Reviews entitled "NK Cells: Tuned by Peptide?" Dr. Das and his colleague, Salim Khakoo, MD, professor of Hepatology at the University of Southhampton, demonstrated that two receptor:ligand systems appear to have complementary functions in recognizing changes in major histocompatibility complex (MHC) class I, for which natural killer (NK) cells express multiple receptors.

Planning, Teamwork and Technology Essential to Conjoined Twins' Separation

William C. Ray, PhD, a principal investigator in the Battelle Center for Mathematical Medicine, helped create a 3D-printed model to facilitate the work of a surgical team consisting of over 30 specialists from plastic surgery, colorectal surgery, neurosurgery, anesthesiology and nursing which led to the successful separation of Acen and Apio, conjoined twin girls from Uganda. 

>> Read more in the recent Pediatrics Nationwide article.
 

Researcher Authors Book Chapter to Benefit the Dyslexia Foundation

Christopher Bartlett, PhD, a principal investigator in the Battelle Center for Mathematical Medicine, authored a chapter in the recently released book, "Advances in Reading Intervention: Research to Practice to Research," sponsored by the non-profit Dyslexia Foundation as part of the Extraordinary Brain Series. All proceeds from the book go to research and activities supporting persons with reading disabilities.
 

Invited Speaker at International Genetic Epidemiology Society Meeting

Meng Wang, PhD, a postdoctoral researcher in Dr. William Stewart's lab in the Battelle Center for Mathematical Medicine, was selected to speak at the upcoming International Genetic Epidemiology Society Meeting in Baltimore, Maryland. Dr. Wang will describe a new statistical test (POPFAM+) that uses sophisticated computational techniques to identify genetic variants influencing common, complex diseases.
 

Invited Speaker at the Institute for Computational Biology Symposium on Precision Medicine

William Stewart, PhD, a principal investigator in the Battelle Center for Mathematical Medicine, has been invited to speak at the Institute for Computational Biology Symposium on Precision Medicine, which will be hosted by Case Western Reserve University on September 22, 2015. His talk will address important statistical and computational challenges inherent to the analysis of Big Data. Dr. Stewart also recently spoke at the Summer Scientists Education Series, and his talk, "Hard Work, Youth and Discipline: A Crossroad between Mathematics and Science" was well-received by attendees.
 

Undergraduate Student in Greenberg Lab Awarded First Place in Summer Poster Competition

Abigail Neininger, an undergraduate student in Dr. David Greenberg's lab, was awarded first place in the undergraduate category for the 2015 summer poster competition at The Research Institute for her poster, "Genetic Variation in Introns as a Cause of Disease: The 'Other' Genetic Code."

>> View the poster here (.PDF)
 

Publication in Entropy on July, 15, 2015

Jayajit Das, PhD, principal investigator in the Battelle Center for Mathematical Medicine and assistant professor of Pediatrics at The Ohio State University, published "Maximum Entropy Estimation of Probability Distribution of Variables in Higher Dimensions from Lower Dimensional Data" in the journal Entropy on July 15, 2015. The article was authored by Dr. Das, Sayak Mukherjee, PhD, and Susan E. Hodge, DSc.
 

Presentation at 2015 Meeting of the Society for Philosophy of Science in Practice

Veronica J. Vieland, PhD, presented "Is Rigorous Measurement of Statistical Evidence Possible?" at the 2015 meeting of the Society for Philosophy of Science in Practice in Aarhus, Denmark.
 

Presentation at the 2015 Making of Measurement Conference

Veronica J. Vieland, PhD, spoke on "Measurement of Evidence in Theory and in Practice" at the 2015 Making of Measurement conference in Cambridge, United Kingdom.
 

Paper Published in Journal Entropy

Veronica J. Vieland, PhD, and Sang Cheol-Seok, PhD, published a new paper, "Statistical Evidence Measured on a Properly Calibrated Scale Across Nested and Non-Nested Hypothesis Comparisons," in the journal Entropy.

>> View abstract here
 

Biological Sciences at Columbia University

Veronica J. Vieland, PhD, was a guest speaker in Biological Sciences at Columbia University (New York, NY) on March 9, 2015. The title of her talk was "Measuring Statistical Evidence in Biological Research."

>> View event details and the abstract here
 

Big Data: Ride the Bandwagon, Sell Hot Dogs at the Show, or Jump Out of the Way?

William Ray, PhD, discusses big data and its problems and opportunities in a recent In Brief for Pediatrics Nationwide. 

>> Read more on the Pediatrics Nationwide website
 

Symposium for 2015 Meeting of the American Association for the Advancement of Science

Veronica Vieland, PhD, organized the symposium, "Extracting Evidence from Biological Data: Multiple Disciplines Get In on the Act" for the 2015 meeting of the American Association for the Advancement of Science.

>> Read more on the website for the AAAS 2015 Annual Meeting
 

"Top 10 Scientific Mysteries for the 21st Century"

Mystery #7 includes measurement of evidence, based on a publication from Vieland et al. (Science News, January 28, 2015). 

>> Read more about the publication here
 

Researcher at Nationwide Children’s Hospital Secures Grant to Develop a Standard Statistical Evidence Measure to Reduce Errors in Biomedical Research

Veronica Vieland, PhD, was recently awarded a grant from the W.M. Keck Foundation for her research study, “Measuring the Evidence in Evidence-Based Medical Research.” (Research News Room)
 

Genetics of Epilepsy Study Currently Underway at Nationwide Children's Hospital

David Greenberg, PhD, is principal investigator of the study for children and adolescents with epilepsy and their families. (November 2015 Research Now)
 

Proceedings of the National Academy of Sciences Features Podcast Interview with Veronica Vieland, PhD, Director of Battelle Center for Mathematical Medicine

In a recent podcast interview featured in Science Sessions, the podcast program for the Proceedings of the National Academy of Sciences (PNAS) of the United States, Veronica Vieland, PhD, discusses a common disconnect between scientists and statisticians in evaluating scientific evidence. 

To learn more about the podcast interview, which was featured on November 17, 2014, please visit the PNAS website for the Science Sessions podcast program.

A transcript of the entire podcast interview can be directly downloaded here, and the MP3 file is also directly accessible through this link.

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