Vitamin D deficiency in populations with mental health disorders Dr. Gracious is exploring the role vitamin D deficiency plays in populations with mental health disorders. Data suggests that vitamin D deficiency is associated with depression, risk for diabetes and that there is a relationship between vitamin D deficiency and bone health, milk intake and food security in adults with major depression. She plans to study whether or not adolescents with vitamin D deficiency who receive vitamin D supplementation when entering treatment will experience better response to depression treatment and metabolic health.
Bone health in children and adolescents with mental disorders Dr. Gracious is leading a pilot project funded by Nationwide Children’s Hospital examining bone density in children and adolescents who have taken SSRI antidepressants for at least 2 years. Basic science data, epidemiologic studies of late life depression, and clinical reports indicate that SSRIs are associated with increased risk for fracture. We will use this data to apply for NIH funding to explore mechanisms and preventive strategies.
She is also examining whether bone biomarkers in adolescent girls might predict who is at risk for bone loss when prescribed an SSRI antidepressant.
Metabolic health in adolescents Dr. Gracious also plans to examine the use of a low omega-6, high omega-3 dietary intervention in adolescents with elevated lipid profiles who are being treated with second generation antipsychotics to lower their cardiovascular risk for future heart disease. Future work may also prospectively examine the risk for hypertension and related factors in adolescents with major mood disorders.
The Gracious Lab focuses on metabolic health risk and prevention in adolescents with mood disorders. Overall Dr. Gracious uses a lifespan perspective to unify physical and emotional health of children at risk.
Gracious BL, Llana M, Barton DD. “Lithium and geographic tongue.” J Am Acad Child Adolesc Psychiatry 1999 Sep;38(9):1069-70.
Findling RL, McNamara NK, Gracious BL, Youngstrom EA, Stansbrey RJ, Reed MD, Demeter CA, Branicky LA, Fisher KE, Calabrese JR. “Combination lithium and divalproex in pediatric bipolarity” J Am Acad Child Adolesc Psychiatry, 2003 Aug;42(8):895-901.
Gracious BL, Meyer A. “Psychotropic-Induced Weight Gain and Potential Pharmacologic Treatment Strategies.” Psychiatry 2005; (2)1:36-40 (invited manuscript)
Findling RL, McNamara NK, Youngstrom EA, Stransbrey R, Gracious BL, Reed MD, Shelton M, Calabrese JR. “Double blind 18-month trial of lithium versus divalproex maintenance treatment in children and adolescents with bipolar disorder”. J Am Acad Child Adolesc Psychiatry 2005;44(5):409-17.
Gracious BL, Youngstrom EA, Findling RL, Calabrese JR. “Discriminative validity of a parent version of the Young Mania Rating Scale.” J Am Acad Child Adolesc Psychiatry, 2002;41(11):1350-9.
Gracious, BL. “Reproductive endocrine changes in women taking valproate: Part 1.” Int Drug Ther News 2000;35(7):1-2. (peer-reviewed)
Findling RL, McNamara NK, Gracious BL, O’Riordan MA, Reed MD, Demeter C, Blumer JL. “Quetiapine in Nine Youths with Autistic Disorder” J Child Adolesc Psychopharmacol, 2004 Summer;14(2):287-94.
Gracious BL, Abe N, Sundberg, J. The Importance of Taking a History of Over-The-Counter Medication Use: A brief review and case illustration of “prn” antihistamine dependence in a hospitalized adolescent. J Child Adolesc Psychopharmacol. 2010 Dec;20(6):521-4.
Youngstrom EA, Gracious BL, Danielson CK, Findling RL, Calabrese J. “Toward an intergration of parent and clinician report on the Young Mania Rating Scale” J Affect Disord, 2003 Nov;77(2):179-90.
Findling RL., Gracious BL, McNamara N, Calabrese J. “The rationale, design and progress of two novel maintenance treatment studies in pediatric bipolarity.” Acta Neuropsychiatrica 2000;12: 136-138.
Gracious, BL. “Elevated TSH in bipolar youth prescribed both lithium and divalproex sodium.” Int Drug Ther News 2001 Oct. (peer-reviewed)
Campo JV, Stowe R, Slomka G, Byler D, Gracious BL. “Psychosis as a presentation of physical disease in adolescence: a case of Niemann-Pick disease, type C.” Developmental Medicine & Child Neurology 1998;40:126-129.
Findling RL, Short EJ, McNamara N, Stansbrey RJ, Demeter, CA, Gracious BL, Whipkey R, Manos MJ, Calabrese JR. “Methylphenidate in the treatment of children and adolescents with bipolar disorder and attention-deficit/hyperactivity disorder.” J Am Acad Child Adolesc Psychiatry 2007 (46):11; 1445-1453.
Gracious BL. Hanusa BH. Wisner KL. Peindl KS. Perel JM. “Weight changes in postpartum women with remitted depression.” Journal of Clinical Psychiatry 2005; 66(3):291-3
Gracious BL, Chirieac MC, Costescu S, Finucane TL, Youngstrom EA, Hibbeln JR. Randomized, placebo-controlled trial of flax oil in pediatric bipolar disorder. Invited manuscript, Bipolar Disord 2010: 12: 142–154.
Gracious, B. “Reproductive endocrine changes in women taking valproate: Part 2 – Children & Adolescents.” International Drug Therapy Newsletter.2000;35(8):1-2. (peer-reviewed)
Gracious, BL. “Atypical antipsychotics and hyperprolactinemia.” International Drug Therapy News 2000;35(1):1-3. (peer-reviewed)
Findling RL, Gracious BL, Stansbrey RJ. “Antidepressant pharmacotherapy of ADHD – children and adolescents.” Int Drug Ther News 2001, Nov
Wagner KD, Hirschfeld RM, Emslie GJ, Findling RL, Gracious BL, Reed ML. “Validation of the Mood Disorder Questionnaire for bipolar disorders in adolescents.” Journal of Clinical Psychiatry 67(5):827-830, 2006 May.
Gracious, B. “Reproductive endocrine changes in women taking valproate: Part 3 – Management Strategies.” International Drug Therapy Newsletter, 2000;35(9):1-2. (peer-reviewed)
Gracious BL, Wisner KL. “Phenelzine use throughout pregnancy and the puerperium: case report, review of the literature, and management recommendations.” Depression Anxiety 1997;6(3):124-8.
Findling RL, Gracious BL, McNamara NK, Youngstrom EA, Demeter CA, Branicky LA, Calabrese JR. ‘Rapid, continuous cycling and psychiatric co-morbidity in pediatric bipolar I disorder.” Bipolar Disord 2001 Aug;3(4):202-210.
Youngstrom EA, Danielson CK, Findling RL, Gracious BL, Calabrese JR. “Factor structure of the Young Mania Rating Scale for use with youths ages 5 to 17 years.” J Clin Child and Adolesc Psychol, 2002 Dec;31(4):567-72.
Findling RL, Frazier TW, Youngstrom EA, McNamara NK, Stansbrey RJ, Gracious BL, Reed MD, Demeter CA. Calabrese JR,; "Double-blind, placebo-controlled trial of divalproex monotherapy in the treatment of symptomatic youth at high risk for developing bipolar disorder". J.Clin.Psychiatry 68 (2007): 781-788.
Gracious BL, Findling RL. “Antipsychotic medications for children and adolescents.” Pediatric Ann 2001 Mar:30(3);138-145.
Gracious BL, Cook S, Meyers AE, Chirieac MC, Malhi N, Fischetti A, Ma Y. “Prevalence of overweight in adolescents with severe mental illness.” 2010 May 4 (Epub ahead of print); J Clin Psychiatry
Youngstrom EA, Findling RL, Calabrese JR, Gracious BL, Demeter C, Bedoya DD, Price M. “Comparing the diagnostic accuracy of six potential screening instruments for bipolar disorder in youths aged 5 to 17 years.” J Am Acad Child Adolesc Psychiatry. 2004 Jul;43(7):847-58.
Gracious BL, Findling RL, Seman C, Youngstrom EA, Demeter CA, Calabrese JR. “Elevated thyrotropin in bipolar youths prescribed both lithium and divalproex sodium.” J Am Acad Child Adolesc Psychiatry, 2004 Feb;43(2):215-20.