Amanda E. Graf, MD :: Nationwide Children's Hospital, Columbus, Ohio
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Amanda E. Graf, MD

Amanda E. Graf, MD

Center for Perinatal Research
Principal Investigator

Neonatology
Physician Team

Contact Information

Neonatology
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-4559
FX: (614) 722-4541

Location Information for Patients

Main Campus

Biography

Amanda E. Graf, MD is a neonatologist and a physician-scientist in the Center for Perinatal Research at the Research Institute at Nationwide Children's Hospital. She is active in laboratory-based research and also serves as a site principal investigator for a clinical trial through the NICHD Neonatal Research Network. She is passionate about providing the best possible care for all babies in the NICU as well as finding ways to improve outcomes for these vulnerable patients. Dr. Graf's laboratory focuses on identifying how changes in the maternal environment, specifically inflammation either from infection or obesity, can affect fetal and neonatal brain development. Understanding how maternal inflammation impacts neurodevelopment may allow scientists to identify new strategies to prevent or treat brain injury in very preterm infants and improve long-term neurodevelopment for children born prematurely.

Gender:

  • Female

Languages Spoken:

  • English

Clinical Interests

  • Premature Infant Care
  • Educating Trainees
  • Care for Babies with Concern for Neurologic Injury
  • Management of Patients Requiring ECMO
  • Supporting and Empowering NICU Parents

Research Interests

Research Center:

Areas of Interest:

  • Impact of Maternal High Fat Diet/Obesity on Neurodevelopment in the Offspring
  • Dr. Graf’s research focuses on increasing understanding of brain injury in preterm infants. Specifically, she is working to develop an animal model to investigate how changes in maternal health and inflammation affect the risk and degree of perinatal brain injury and the mechanisms of these injuries. The goal of her research is to develop new strategies to prevent and treat brain injury in preterm infants.
  • Perinatal Brain Development and Injury
  • Effect of Maternal Inflammation and Hyperoxia on Microglial Activation

Education and Training

Medical School

  • Ohio State University
    Date Completed: 06/11/2006

Residency

  • Hasbro Children's Hospital
    Date Completed: 06/30/2009

Fellowship

  • Children's Hospital Colorado
    Date Completed: 09/07/2012

Department:

  • Pediatrics

Section:

  • Neonatology

Specialty:

  • Neonatal-Perinatal Medicine
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 10/01/2012

Publications

  • Graf,Amanda,E; Haines,Krista,M; Pierson,Christopher,R; Bolon,Brad,N; Houston,Ronald,H; Velten,Markus; Heyob,Kathryn,M; Rogers,Lynette,K. 2014. Perinatal inflammation results in decreased oligodendrocyte numbers in adulthood.  LIFE SCIENCES. Vol. 94, no. 2. (January): 164-171.
  • Graf,Amanda,E; Haines,Krista,M; Pierson,Christopher,R; Bolon,Brad,N; Houston,Ronald,H; Velten,Markus; Heyob,Kathryn,M; Rogers,Lynette,K. 2014. Perinatal inflammation results in decreased oligodendrocyte numbers in adulthood.  LIFE SCIENCES. Vol. 94, no. 2. (January): 164-171.
  • Graf,Amanda,E; Haines,Krista,M; Pierson,Christopher,R; Bolon,Brad,N; Houston,Ronald,H; Velten,Markus; Heyob,Kathryn,M; Rogers,Lynette,K. 2014. Perinatal inflammation results in decreased oligodendrocyte numbers in adulthood.  Life sciences. Vol. 94, no. 2. (January): 164-171.
  • Rogers,Lynette,K; Graf,Amanda,E; Bhatia,Anisha; Leonhart,Karen,L; Oza-Frank,Reena. 2013. Associations between Maternal and Infant Morbidities and sRAGE within the First Week of Life in Extremely Preterm Infants.  PLOS ONE. Vol. 8, no. 12. (December): ee82537.
  • Rogers,Lynette,K; Graf,Amanda,E; Bhatia,Anisha; Leonhart,Karen,L; Oza-Frank,Reena. 2013. Associations between Maternal and Infant Morbidities and sRAGE within the First Week of Life in Extremely Preterm Infants.  PLOS ONE. Vol. 8, no. 12. (December): ee82537.
  • Marean,Amber; Graf,Amanda; Zhang,Ying; Niswander,Lee. 2011. Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival.  HUMAN MOLECULAR GENETICS. Vol. 20, no. 18. (September): 3678-3683.

Awards, Honors and Organizations

  • Member, Society for Neuroscience, 2014-Present
  • Fellow, American Academy of Pediatrics, Section of Neonatal-Perinatal Medicine, 2006-Present
  • Gold Humanism Honor Society Inductee, 2005
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000