Leif D. Nelin, MD :: Nationwide Children’s Hospital, Columbus, Ohio

Leif D. Nelin, MD

Leif D. Nelin, MD Best Doctors 2011-2012

Center for Perinatal Research
Principal Investigator

Neonatology
Division Chief

Neonatology Fellowship
Faculty

Contact Information

Neonatology
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-4559
FX: (614) 722-4541
E-mail Me
The Research Institute at Nationwide Children's Hospital
700 Children's Drive
Columbus, Ohio 43205 [ map ]
PH: (614) 722.2700
FX: (614) 355.3455

Biography

Dr. Nelin is the Division Chief of Neonatology at Nationwide Children’s Hospital and a Professor of Pediatrics at The Ohio State University College of Medicine. Clinically, Dr. Nelin is particularly interested in respiratory diseases, specifically in how pulmonary blood flow affects newborn respiratory diseases. Thus, persistent pulmonary hypertension of the newborn(PPHN) is one of his primary clinical interests. This has lead to his research interest in nitric oxide (NO), a potent vasodilator whose production is decreased in patients with PPHN. Utilizing cell culture techniques, isolated perfused lungs and animal preparations, Dr. Nelin studies the mechanisms that determine biological availability of the amino acid L-arginine on the ability of the lungs to produce NO and thereby regulate blood flow. The ultimate goal of this research is to understand the pathophysiology of PPHN and to develop new and specific therapies for the treatment of lung diseases that are characterized by alterations in NO production. A second area of research interest is the study of the developmental toxicology of inhaled NO.

Gender:

  • Male

Languages Spoken:

  • English
  • Swedish

Research Interests

Research Center:

Areas of Interest:

  • The research focus in my laboratory is on the elucidation of the functional and mechanistic aspects of cellular uptake of L-arginine by the cationic amino acid transporters (CAT) and the role of CAT activities and expression in regulation of nitric oxide (NO) production in the lung. Furthermore, we are studying the regulation of nitric oxide synthase and arginase induction in models of pulmonary hypertension and lung injury to develop strategies to influence arginine metabolism inside of the cell. Experiments are carried out in cell culture systems and animal models using pharmacological and genetic manipulations with experimental end-points ranging from biochemical assays, protein and mRNA assays, to functional and physiological measurements. The long-term goals of these studies are to develop therapies that increase NO production by facilitating CAT-mediated L-arg uptake in pulmonary hypertensive diseases, and that decrease NO production by inhibiting CAT-mediated L-arg uptake in inflammatory lung diseases.

Research Funding*:

  • The Role of MKP-1 in Innate Immune Responses to bacterial cell wall components, NIH/NIAID
  • Cationic Amino Acid Transporters and Lung NO Production, National Heart, Lung and Blood Institute

Education and Training

Undergraduate School

  • Florida Atlantic University
    Date Completed: 06/30/1979

Medical School

  • University of South Florida
    Date Completed: 06/12/1982

Internship

  • Baylor College of Medicine
    Date Completed: 06/30/1983

Residency

  • Baylor College of Medicine
    Date Completed: 06/30/1985

Residency

  • Uppsala University
    Date Completed: 01/01/1986

Fellowship

  • Baylor College of Medicine
    Date Completed: 06/30/1988

Department:

  • Pediatrics

Section:

  • Neonatology

Specialty:

  • Neonatal-Perinatal Medicine

Date of Appointment at Nationwide Children’s Hospital:

  • 05/23/2003

Professional Experience

2010–present

  • Interim Chief, Division of Neonatology, The Ohio State University

2007–present

  • Director, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH

2002–present

  • Associate Professor, Department of Pediatrics, Ohio State University, Columbus, Ohio

2006–2007

  • Interim Director, Center for Perinatal Research Nationwide Children's Research Institute, Columbus, Ohio

2002–2006

  • Investigator, Center for Developmental Pharmacology and Toxicology, Columbus Children's Research Institute, Columbus, OH

1998–2002

  • Associate Professor, Department of Pediatrics, University of New Mexico, Albuquerque, NM

1994–1998

  • Associate Professor, Department of Pediatrics, Medical college of Wisconsin, Milwaukee, WI

1994–1998

  • Adjunct Associate Professor, Biomedical engineering Department, Marquette University, Milwaukee, WI

1989–1994

  • Assistant Professor, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI

1989–1994

  • Adjunct Assistant Professor, Biomedical Engineering Department, Marquette University, Milwaukee, WI

1988–1989

  • Instructor, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI

Publications

  • Matta,Ranyia; Barnard,John,A; Wancket,Lyn,M; Yan,Jing; Xue,Jianjing; Grieves,Jessica; Frazier,W,Joshua; Nelin,Leif; Cato,Andrew,CB; Liu,Yusen. 2012. Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice.  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. Vol. 302, no. 11. (June): G1322-G1335.
  • Stenger,Michael,R; Slaughter,Jonathan,L; Kelleher,Kelly; Shepherd,Edward,G; Klebanoff,Mark,A; Reagan,Patricia; Nelin,Leif,D; Gardner,William. 2012. Hospital Variation in Nitric Oxide Use for Premature Infants.  PEDIATRICS. Vol. 129, no. 4. (April): E945-E951.
  • Yan J, Meng X, Wancket LM, Lintner K, Nelin LD, chen B, Francis KP, Smith CV, Rogers LK, Liu Y. 2012. Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting in the development of neutrophil extracellular traps.  J Immunol. Vol. 188, no. 5. (March): 2316-27.
  • Stenger MR, Slaughter JL, Kelleher K, Shepherd EG, Klebanoff MA, Regan P, Nelin LD, Gardner W. 2012. Hospital variation in nitric oxide use for premature infants.  Pediatrics. Vol. 124, no. 4. (March): e945-51.
  • Yan,Jing; Meng,Xiaomei; Wancket,Lyn,M; Lintner,Katherine; Nelin,Leif,D; Chen,Bernadette; Francis,Kevin,P; Smith,Charles,V; Rogers,Lynette,K; Liu,Yusen. 2012. Glutathione Reductase Facilitates Host Defense by Sustaining Phagocytic Oxidative Burst and Promoting the Development of Neutrophil Extracellular Traps.  JOURNAL OF IMMUNOLOGY. Vol. 188, no. 5. (March): 2316-2327.
  • Britt RD Jr, Locy ML, Tipple TE, Nelin LD, Rogers LK. 2012. Lipopolysaccharide-induced cyclooxygenase-2 expression in mouse transformed Clara cells.  Cell Physiol Biochem. Vol. 29, no. 1-2. (March): 213-22.
  • Britt,Rodney,D; Locy,Morgan,L; Tipple,Trent,E; Nelin,Leif,D; Rogers,Lynette,K. 2012. Lipopolysaccharide-induced Cyclooxygenase-2 Expression in Mouse Transformed Clara Cells.  CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. Vol. 29, no. 1-2. (January): 213-222.
  • Cui,Hongmei; Chen,Bernadette; Chicoine,Louis,G; Nelin,Leif,D. 2011. Overexpression of cationic amino acid transporter-1 increases nitric oxide production in hypoxic human pulmonary microvascular endothelial cells.  CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY. Vol. 38, no. 12. (December): 796-803.
  • Backes,Carl,H; Moorehead,Pamela,A; Nelin,Leif,D. 2011. Cancer in Pregnancy: Fetal and Neonatal Outcomes.  CLINICAL OBSTETRICS AND GYNECOLOGY. Vol. 54, no. 4. (December): 574-590.
  • Cua,Clifford,L; Rogers,Lynette,K; Chicoine,Louis,G; Augustine,Molly; Jin,Yi; Nash,Patricia,L; Nelin,Leif,D. 2011. Down syndrome patients with pulmonary hypertension have elevated plasma levels of asymmetric dimethylarginine.  EUROPEAN JOURNAL OF PEDIATRICS. Vol. 170, no. 7. (July): 859-863.
  • Chicoine,Louis,G; Stenger,Michael,R; Cui,Hongmei; Calvert,Andrea; Evans,Rebecca,J; English,B,Keith; Liu,Yusen; Nelin,Leif,D. 2011. Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine-stimulated pulmonary endothelial cells.  American journal of physiology. Lung cellular and molecular physiology. Vol. 300, no. 4. (April): L596-604.
  • Chicione,Louis,G; Stenger,Michael,R; Cui,Hongmei; Calvert,Andrea; Evans,Rebecca,J; English,B,Keith; Liu,Yusen; Nelin,Leif,D. 2011. Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine-stimulated pulmonary endothelial cells.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 300, no. 4. (April): L596-L604.
  • Stenger MR, Rose MJ, Joshi MS, Rogers LK, Chicoine LG, Bauer JA, Nelin LD. 2010. Inhaled nitric oxide prevents 3-nitrotyrosine formation in the lungs of neonatal mice exposed to >95% oxygen.  Lung. Vol. 3, no. 188. (June): 217-227.
  • Toby,Inimary,T; Chicoine,Louis,G; Cui,Hongmei; Chen,Bernadette; Nelin,Leif,D. 2010. Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 298, no. 4. (April): L600-L606.
  • Rose MJ; Stenger MR; Joshi MS; Welty SE; Bauer JA; Nelin LD. 2010. Inhaled nitric oxide decreases leukocyte trafficking in the neonatal mouse lung during exposure to >95% oxygen.  Pediatric Research. Vol. 67, no. 3. (March): e244.
  • Toby IT, Chicoine LG, Cui H, Chen B, Nelin LD. 2010. Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation.  Am J Physiol Lung Cell Mol Physiol.
  • Nankervis CA, Martin EM, Crane ML, Samson KS, Welty SE, Nelin LD. 2010. Implementation of a multidiscplinary guideline-driven approach to the care of the extremely premature infant improved hospital outcomes.  Acta Paediatr. Vol. 2, no. 99. (February): 188-193.
  • Robert G Castile and Leif D Nelin. 2010. Lung function, structure and the physiologic basis for mechanical ventilation of infants with established BPD. In Brochopulmonary Dysplasia. Edited by Steven H Abman. New York: Lippincott.
  • Frazier WJ; Wang X; Wancket LM; Li XA; Meng X; Nelin LD; Cato AC; Liu Y. 2009. Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice.  Journal Of Immunology (Baltimore, Md.: 1950). Vol. 183, no. 11. (December): e7411.
  • Chen B; Calvert AE; Cui H; Nelin LD. 2009. Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase.  American Journal Of Physiology. Lung Cellular And Molecular Physiology. Vol. 297, no. 6. (December): eL1151.
  • Chen,Bernadette; Calvert,Andrea,E; Cui,Hongmei; Nelin,Leif,D. 2009. Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 297, no. 6. (December): L1151-L1159.
  • Wang X; Zhao Q; Matta R; Meng X; Liu X; Liu CG; Nelin LD; Liu Y. 2009. Inducible nitric-oxide synthase expression is regulated by mitogen-activated protein kinase phosphatase-1.  The Journal Of Biological Chemistry. Vol. 284, no. 40. (October): e27123.
  • Nankervis Ca, Martin EM, Crane ML, Samson KS, Welty SE, Nelin LD. 2009. Implementation of a multidisciplinary guideline-driven approach to the care of the extremely premature infant improved hospital outcomes.  Acta Paediatr.
  • Matta R, Wang X, Ge H, Ray W, Nelin LD, Liu Y. 2009. Triptolide induces anti-inflammatory cellular responses.  Am J Transl Res. Vol. 3, no. 1. (March): 267-282.
  • Rogers LK, TE Tipple, LD Nelin and SE Welty. 2009. Differential responses in the lungs of newborn mouse pups exposed to 85% or >95% oxygen.  Pediatr Res. Vol. 65, no. January: 33-38.
  • Matta R, X Wang, H Ge, W Ray, LD Nelin and Y Liu. 2009. The anti-inflammatory mechanism of triptolide.  AM J Transl Res.
  • Chang,Rossana; Chicoine,Louis,G; Cui,Hongmei; Kanagy,Nancy,L; Walker,Benjimen,R; Liu,Yusen; English,B,Keith; Nelin,Leif,D. 2008. Cytokine-induced arginase activity in pulmonary endothelial cells is dependent on Src family tyrosine kinase activity.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 295, no. 4. (October): L688-L697.
  • Chang R, Chicoine LG, Cui H, Kanagy NL, Walker BR, Liu Y, English BK, Nelin LD. 2008. Cytokine-induced arginase activity in pulmonary endothelial cells in dependent on Src family tyrosine kinase activity.  Am J Physiol Lung Cell Mol Physiol.. Vol. 295, no. 4. (October): L688-L697.
  • Wang X, Nelin LD, Kuhlman JR, Meng X, Welty SE, Liu Y. 2008. The role of MAP kinase phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia.  Life Sci.. Vol. 82, no. 19-20. (September): 671-680.
  • Allahdadi KJ, Cherng TW, Pai H, Silva AQ, Walker BR, Nelin LD, Kanagy NL. 2008. A receptor antagonist normalizes blood pressure in rats exposed to eucapnic intermittent hypoxia.  Am J Physiol Heart Circ Physio.. Vol. 295, no. 1. (July): H434-H440..
  • Calvert TJ, Chicoine LG, Liu Y, Nelin LD. 2008. Deficiency of mitogen-activiated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin.  Am J Physiol Heart Circ Physiol.. Vol. 294, no. 4. (April): H1621-H1629.
  • Jadcherla SR, Gupta A, Fernandez S, Nelin LD, Castile R, Gest AL, Welty S. 2008. Spatiotemporal characteristics of acid refluxate and relationship to symptoms in premature and term infants with chronic lung disease.  Am J Gastroenterol.. Vol. 103, no. 3. (March): 720-728.
  • Nelin LD, DT Malleske, MR Stenger, and LG Chicoine. 2007. Vascular arginase and hypertension.  Current Hypertension Review 3. Vol. 3, no. January: 242-249.
  • Cua CL, A Blankenship, AL North, J Hayes and LD Nelin. 2007. Increased incidence of idiopathic persistent pulmonary hypertension in Down syndrome neonates.  Pediatric Cardiology. Vol. 28, no. January: 250-254.
  • Nelin LD, Wang X, Zhao Q, Chicoine LG, Young TL, Hatch DM, English BK, Liu Y. 2007. MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge.  American Journal of Physiology - Cell Physiology. Vol. 293, no. 2. (January): C632-C640.
  • Nankervis CA, Preston TJ, Dysart KC, Wilkinson WD, Chicoine LG, Welty SE,Nelin LD. 2007. Assessing heparin dosing in neonates on venoarterial extracorporeal membrane oxygenation.  ASAIO Journal. Vol. 53, no. 1. (January): 111-114.
  • Wang X, Meng X, Kuhlman JR, Nelin LD, Nicol KK, English BK, Liu Y. 2007. Knockout of Mkp-1 enhances the host inflammatory responses to gram-positive bacteria.  Journal of Immunology. Vol. 178, no. 8. (January): 5312-5320.
  • Liu Y, Shepherd EG, Nelin LD. 2007. MAPK phosphatases--regulating the immune response.  Nature Reviews Immunology. Vol. 7, no. 3. (January): 202-212.
  • Chicoine LG, Paffett ML, Girton MR, Metropoulus MJ, Joshi MS, Bauer JA, Nelin LD, Resta TC, Walker BR. 2007. Maturational changes in the regulation of pulmonary vascular tone by nitric oxide in neonatal rats.  American Journal of Physiology - Lung Cellular & Molecular Physiology. Vol. 293, no. 5. (January): L1261-L1270.
  • Malleske, Daniel, T; Rogers, Lynette, K; Velluci, Sean, M; Young, Tamara, L; Park, Min, S; Long, Donald, W; Welty, Stephen, E; Smith, Charles, V; Nelin, Leif D. 2006. Hyperoxia increases hepatic arginase expression and ornithine production in mice.  Toxicology and applied pharmacology. Vol. 215, no. 1. (January): 109-17.
  • Wang, Xianxi; Matta, Ranyia; Shen, Gang; Nelin, Leif, D; Pei, Dehua; Liu, Yusen. 2006. Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide.  Journal of molecular medicine (Berlin, Germany). Vol. 84, no. 5. (January): 405-15.
  • Zhao, Qun; Wang, Xianxi; Nelin, Leif D; Yao, Yongxue; Matta, Ranyia; Manson, Mary E; Baliga, Reshma S; Meng, Xiaomei; Smith, Charles V; Bauer, John A; Chang, Cheong-Hee; Liu, Yusen. 2006. MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock.  The Journal of experimental medicine. Vol. 203, no. 1. (January): 131-40.
  • Stanley, Kate P; Chicoine, Louis G; Young, Tamara L; Reber, Kristina M; Lyons, C Richard; Liu, Yusen; Nelin, Leif D. 2006. Gene transfer with inducible nitric oxide synthase decreases production of urea by arginase in pulmonary arterial endothelial cells.  American journal of physiology. Lung cellular and molecular physiology. Vol. 290, no. 2. (January): L298-306.
  • Nelin,L,D; Chicoine,L,G; Reber,K,M; English,B,K; Young,T,L; Liu,Y,S. 2005. Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 33, no. 4. (October): 394-401.
  • Hoffman, George M; Nelin, Leif D. 2005. Mean airway pressure and response to inhaled nitric oxide in neonatal and pediatric patients.  Lung. Vol. 183, no. 6. (January): 441-53.
  • Zhao, Qun; Shepherd, Edward G; Manson, Mary E; Nelin, Leif D; Sorokin, Andrey; Liu, Yusen. 2005. The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38.  The Journal of biological chemistry. Vol. 280, no. 9. (January): 8101-8.
  • Nelin, Leif D; Chicoine, Louis G; Reber, Kristina M; English, B Keith; Young, Tamara L; Liu, Yusen. 2005. Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor.  American journal of respiratory cell and molecular biology. Vol. 33, no. 4. (January): 394-401.
  • Chicoine, Louis G; Paffett, Michael L; Young, Tamara L; Nelin, Leif D. 2004. Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells.  American journal of physiology. Lung cellular and molecular physiology. Vol. 287, no. 1. (January): L60-8.
  • Chicoine, Louis G; Tzeng, Edith; Bryan, Rebekah; Saenz, Steven; Paffett Michael, L; Jones, Joelle; Lyons, C Richard; Resta, Thomas C; Nelin, Leif D; Walker, Benjimen R. 2004. Intratracheal adenoviral-mediated delivery of iNOS decreases pulmonary vasoconstrictor responses in rats.  Journal of applied physiology (Bethesda, Md. : 1985). Vol. 97, no. 5. (January): 1814-22.
  • Carter, Barney W Jr; Chicoine, Louis G; Nelin, Leif D. 2004. L-lysine decreases nitric oxide production and increases vascular resistance in lungs isolated from lipopolysaccharide-treated neonatal pigs.  Pediatric research. Vol. 55, no. 6. (January): 979-87.
  • Malvin,GM; Cecava,N; Nelin,LD. 2003. Nitric oxide production and thermoregulation in Paramecium caudatum.  ACTA PROTOZOOLOGICA. Vol. 42, no. 4. (November): 259-267.
  • Turley, Joyce E; Nelin, Leif D; Kaplowitz, Mark R; Zhang, Yongmei; Fike, Candice D. 2003. Exhaled NO is reduced at an early stage of hypoxia-induced pulmonary hypertension in newborn piglets.  American journal of physiology. Lung cellular and molecular physiology. Vol. 284, no. 3. (January): L489-500.
  • Nelin, Leif D; Morrisey, James F; Effros, Richard M; Dawson, Christopher A; Schapira, Ralph M. 2003. The effect of inhaled nitric oxide and oxygen on the hydroxylation of salicylate in rat lungs.  Pediatric research. Vol. 54, no. 3. (January): 337-43.
  • Chicoine, Louis G; Avitia, Jose W; Deen, Cody; Nelin, Leif D; Earley, Scott; Walker, Benjimen R. 2002. Developmental differences in pulmonary eNOS expression in response to chronic hypoxia in the rat.  Journal of applied physiology (Bethesda, Md. : 1985). Vol. 93, no. 1. (January): 311-8.
  • Earley, Scott; Nelin, Leif D; Chicoine, Louis G; Walker, Benjimen R. 2002. Hypoxia-induced pulmonary endothelin-1 expression is unaltered by nitric oxide.  Journal of applied physiology (Bethesda, Md. : 1985). Vol. 92, no. 3. (January): 1152-8.
  • Nelin, Leif D; Krenz, Gary S; Chicoine, Louis G; Dawson, Christopher A; Schapira, Ralph M. 2002. L-Arginine uptake and metabolism following in vivo silica exposure in rat lungs.  American journal of respiratory cell and molecular biology. Vol. 26, no. 3. (January): 348-55.
  • Kanagy, NL; Walker, BR; Nelin, LD. 2001. Role of endothelin in intermittent hypoxia-induced hypertension.  Hypertension. Vol. 37, no. 2 Part 2. (January): 511-5.
  • Guarin, M; Dawson, C, A; Nelin, LD. 2001. The arterial site of action of nitric oxide in the neonatal pig lung determined by microfocal angiography.  Lung. Vol. 179, no. 1. (January): 43-55.
  • Nelin, LD; Hoffman, GM. 2001. L-arginine infusion lowers blood pressure in children.  The Journal of pediatrics. Vol. 139, no. 5. (January): 747-9.
  • Nelin, LD; Nash, HE; Chicoine, LG. 2001. Cytokine treatment increases arginine metabolism and uptake in bovine pulmonary arterial endothelial cells.  American journal of physiology. Lung cellular and molecular physiology. Vol. 281, no. 5. (January): L1232-9.
  • Bousamra, M 2nd; Rossi, R; Jacobs, E; Parviz, M; Busch, C; Nelin, L, D; Haworth, S; Dawson, C A. 2000. Systemic lobar shunting induces advanced pulmonary vasculopathy.  The Journal of thoracic and cardiovascular surgery. Vol. 120, no. 1. (January): 88-98.
  • Fike, CD; Kaplowitz, MR; Rehorst-Paea, LA; Nelin, LD. 2000. L-Arginine increases nitric oxide production in isolated lungs of chronically hypoxic newborn pigs.  Journal of applied physiology (Bethesda, Md. : 1985). Vol. 88, no. 5. (January): 1797-803.
  • Walker, BR; Resta, TC; Nelin, LD. 2000. Nitric oxide-dependent pulmonary vasodilation in polycythemic rats.  American journal of physiology. Heart and circulatory physiology. Vol. 279, no. 5. (January): H2382-9.
  • Gordon, JB; Rehorst-Paea, LA; Hoffman, GM; Nelin, LD. 1999. Pulmonary vascular responses during acute and sustained respiratory alkalosis or acidosis in intact newborn piglets.  Pediatric research. Vol. 46, no. 6. (January): 735-41.
  • Parviz, M; Bousamra, M 2nd; Chammas, JH; Birks, EK; Presberg, KW; Jacobs, ER; Nelin, LD. 1999. Effects of chronic pulmonary overcirculation on pulmonary vasomotor tone.  The Annals of thoracic surgery. Vol. 67, no. 2. (January): 522-7.
  • Nelin, LD; Hoffman, GM. 1998. The use of inhaled nitric oxide in a wide variety of clinical problems.  Pediatric clinics of North America. Vol. 45, no. 3. (January): 531-48.
  • Fike, CD; Kaplowitz, MR; Thomas, CJ; Nelin, LD. 1998. Chronic hypoxia decreases nitric oxide production and endothelial nitric oxide synthase in newborn pig lungs.  The American journal of physiology. Vol. 274, no. 4 Pt 1. (January): L517-26.
  • Schapira, RM; Wiessner, JH; Morrisey, JF; Almagro, UA; Nelin, LD. 1998. L-arginine uptake and metabolism by lung macrophages and neutrophils following intratracheal instillation of silica in vivo.  American journal of respiratory cell and molecular biology. Vol. 19, no. 2. (January): 308-15.
  • Nelin, LD; Welty, SE; Morrisey, JF; Gotuaco, C; Dawson, CA. 1998. Nitric oxide increases the survival of rats with a high oxygen exposure.  Pediatric research. Vol. 43, no. 6. (January): 727-32.
  • De La Fuente, EK; Dawson, CA; Nelin, LD; Bongard, RD; McAuliffe, TL; Merker, MP. 1997. Biotinylation of membrane proteins accessible via the pulmonary circulation in normal and hyperoxic rats.  The American journal of physiology. Vol. 272, no. 3 Pt 1. (January): L461-70.
  • Hoffman, GM; Ross, GA; Day, SE; Rice, TB; Nelin, LD. 1997. Inhaled nitric oxide reduces the utilization of extracorporeal membrane oxygenation in persistent pulmonary hypertension of the newborn.  Critical care medicine. Vol. 25, no. 2. (January): 352-9.
  • Sasidharan,P; BILLMAN,D; Heimler,R; Nelin,L. 1996. Cardiac arrest in an extremely low birth weight infant: complication of percutaneous central venous catheter hyperalimentation.  Journal of perinatology. Vol. 16, no. 2. (March): 123-126.
  • Nelin, LD; Thomas, CJ; Dawson, CA. 1996. Effect of hypoxia on nitric oxide production in neonatal pig lung.  The American journal of physiology. Vol. 271, no. 1 Pt 2. (January): H8-14.
  • Nelin, LD; Christman, NT; Morrisey, JF; Dawson, CA. 1996. Electrochemical nitric oxide and nitrogen dioxide analyzer for use with inhaled nitric oxide.  Journal of applied physiology (Bethesda, Md. : 1985). Vol. 81, no. 3. (January): 1423-9.
  • Fakler, CR; Kaftan, HA; Nelin, L D. 1995. Two cases suggesting a role for the L-arginine nitric oxide pathway in neonatal blood pressure regulation.  Acta paediatrica (Oslo, Norway : 1992). Vol. 84, no. 4. (January): 460-2.
  • Heimler, R; Nelin, LD; Billman, DO; Sasidharan, P. 1995. Identification of sepsis in neonates following maternal antibiotic therapy.  Clinical pediatrics. Vol. 34, no. 3. (January): 133-7.
  • Nelin, LD; Moshin, J; Thomas, CJ; Sasidharan, P; Dawson, CA. 1994. The effect of inhaled nitric oxide on the pulmonary circulation of the neonatal pig.  Pediatric research. Vol. 35, no. 1. (January): 20-4.
  • Nelin, LD; Rickaby, DA; Linehan, JH; Dawson, CA. 1994. The vascular site of action of hypoxia in the neonatal pig lung.  Pediatric research. Vol. 35, no. 1. (January): 25-9.
  • Sasidharan,P; Heimler,R; BILLMAN,D; Nelin,L. 1993. Traumatic pseudodiverticulum of the pharynx.  Journal of perinatology. Vol. 13, no. 6. (November): 473-475.
  • Heimler, R; Doumas, B, T; Jendrzejczak, B, M; Nemeth, P, B; Hoffman, R, G; Nelin, L D. 1993. Relationship between nutrition, weight change, and fluid compartments in preterm infants during the first week of life.  The Journal of pediatrics. Vol. 122, no. 1. (January): 110-4.
  • Nelin, LD; Dawson, CA. 1993. The effect of N omega-nitro-L-arginine methylester on hypoxic vasoconstriction in the neonatal pig lung.  Pediatric research. Vol. 34, no. 3. (January): 349-53.
  • Nelin, LD; Krenz, GS; Rickaby, DA; Linehan, JH; Dawson, CA. 1993. A distensible vessel model applied to hypoxic pulmonary vasoconstriction in the neonatal pig.  Journal of applied physiology (Bethesda, Md. : 1985). Vol. 74, no. 5. (January): 2049-56.
  • Linehan, JH; Haworth, ST; Nelin, LD; Krenz, GS; Dawson, CA. 1992. A simple distensible vessel model for interpreting pulmonary vascular pressure-flow curves.  Journal of applied physiology (Bethesda, Md. : 1985). Vol. 73, no. 3. (January): 987-94.
  • Nelin, LD; Wearden, ME; Welty, SE; Hansen, TN. 1992. The effect of blood flow and left atrial pressure on the DLCO in lambs and sheep.  Respiration physiology. Vol. 88, no. 3. (January): 333-42.
  • Heimler, R; Langlois, J; Hodel, D, J; Nelin, L, D; Sasidharan, P. 1992. Effect of positioning on the breathing pattern of preterm infants.  Archives of disease in childhood. Vol. 67, no. 3. (January): 312-4.
  • Dawson, CA; Roerig, DL; Rickaby, DA; Nelin, LD; Linehan, JH; Krenz, GS. 1992. Use of diazepam for interpreting changes in extravascular lung water.  Journal of applied physiology (Bethesda, Md. : 1985). Vol. 72, no. 2. (January): 686-93.
  • Nelin, LD; Roerig, DL; Rickaby, DA; Linehan, JH; Dawson, CA. 1992. Influence of flow on pulmonary vascular surface area inferred from blue dextran efflux data.  Journal of applied physiology (Bethesda, Md. : 1985). Vol. 72, no. 3. (January): 874-80.
  • Nelin, LD; Rickaby, DA; Linehan, JH; Dawson, CA. 1991. Effect of atelectasis and surface tension on pulmonary vascular compliance.  Journal of applied physiology (Bethesda, Md. : 1985). Vol. 70, no. 6. (January): 2401-9.
  • Gonya J, Nelin LD. Factors associated with maternal visitation and participation in skin-to-skin care in an all referral level IIIc NICU.  Acta Paediatr.
  • Cua CL, AL Cooper, MA Stein, RJ Corbitt and LD Nelin. Tissue Doppler Changes in Three Neonates with Congenital Diaphragmatic Hernia.  ASAIO J.
  • Jin Y, Chen B, Calvert TJ, Chicoine LG, Liu Y, Nelin LD. Chronic hypoxia devreases arterial and venous compliance in iisolated perfused ray lungs:an effict that is reversed by exogenous L-arginine.  Am J Physiol Heart Circ Physiol.
  • Chen B, Calvert AE, Meng X, Nelin LD. Pharmacologic agents elevating cAMP prevent arginase II expression and proliferation of pulmonary artery smooth muscle cells.  Am J Respir Cell Mol Biol.
  • Tipple TE, SE Welty, LD Nelin, JM Hansen and LK Rogers. Alterations of the Thioredoxin System by Hyperoxia: Implications for Alveolar Development.  Am J Respir Cell Mol Biol.
  • Egan JM, Husain N, Steins JR, Moiduddin N, Stein MA, Nelin LD, Cua CL. Mid-term differences in right ventricular function in patients with congenital diaphragmatic hernia compared with controls.  World J Pediatr.
  • Jin Y, Calvert TJ, Chen B, Chicoine LG, Joshi MS, Bauer JA, Liu Y, Nelin LD. Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia.  Am J Physiol Heart Circ Physiol.

Awards, Honors and Organizations

  • Listed, Best Doctors in America
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